Results 51 to 60 of about 467,505 (266)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Uniqueness Theorem and Midpoint Numerical Technique for Fractal-Fractional Differential Equations With Power Law Kernel

Journal of Applied Mathematics
In this paper, we obtained conditions for the uniqueness of solution and a Crank–Nicholson–type algorithm for fractal-fractional differential equations with a power law kernel in Riemann–Liouville sense. For the uniqueness analysis, Kooi's conditions are
Chinedu Nwaigwe, Abdon Atangana
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Spatiotemporal distribution and human health risks of potential toxic elements in the groundwater of the lower Tista Floodplain, Rangpur, Bangladesh

Discover Water
This study assessed the extent of potential toxic element (PTE) contamination and its associated health risks in groundwater from the Tista Floodplain, Rangpur, northern Bangladesh.
Mir Md Tasnim Alam, Mahfuzur Rahman, Nazmus Sakib, Mahir Tajwar, Md Yousuf Gazi, Shamiha Shafinaz Shreya, Anwar Zahid   +6 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Aquifer hydraulic characteristics using D-Z parameters: a case study of Lohaghat block, Champawat district, Uttarakhand, India

Discover Applied Sciences
This study investigates the geoelectrical properties of shallow aquifers and estimates their hydraulic parameters in the Lohaghat block of the Champawat district, Uttarakhand.
Somvir Singh, Nepal C. Mondal
doaj   +1 more source

Construction and analysis of numerical algorithms for Erdelyi–Kober fractional integral equations

Scientific African
Erdelyi–Kober fractional integral (EKI) operator is a generalization of Riemann–Liouville integral (RLI) and has applications in diverse areas. However, unlike the RLI whose singular kernel is linear in the integration variable, the singular kernel of ...
Chinedu Nwaigwe, Abdon Atangana
doaj   +1 more source

Calculations of groundwater recessions caused by drainage wells in arid climate taking into account the non-uniform inversion of groundwater evaporation

Central Asian Journal of Water Research, 2018
This article discusses dependencies to calculate the vertical drain wells taking into account evaporation inversion. In a zone near the well,where the depth of groundwater level (GWL) is below a critical level, the inversion is set as a constant value ...
Rafael Litvak
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source