Results 51 to 60 of about 485,769 (266)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Uniqueness Theorem and Midpoint Numerical Technique for Fractal-Fractional Differential Equations With Power Law Kernel

open access: yesJournal of Applied Mathematics
In this paper, we obtained conditions for the uniqueness of solution and a Crank–Nicholson–type algorithm for fractal-fractional differential equations with a power law kernel in Riemann–Liouville sense. For the uniqueness analysis, Kooi's conditions are
Chinedu Nwaigwe, Abdon Atangana
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

open access: yesFEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson   +2 more
wiley   +1 more source

Spatiotemporal distribution and human health risks of potential toxic elements in the groundwater of the lower Tista Floodplain, Rangpur, Bangladesh

open access: yesDiscover Water
This study assessed the extent of potential toxic element (PTE) contamination and its associated health risks in groundwater from the Tista Floodplain, Rangpur, northern Bangladesh.
Mir Md Tasnim Alam   +6 more
doaj   +1 more source

The Colon Bacillus in Ground Waters [PDF]

open access: yesJournal of Hygiene, 1903
During the past four years it has been part of our routine work to examine samples of ground waters from wells and springs in various portions of Ohio, and, in so doing, organisms have been obtained from time to time conforming to the tests usually given as differentiating faecal bacteria.
openaire   +3 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

open access: yesFEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana   +5 more
wiley   +1 more source

Aquifer hydraulic characteristics using D-Z parameters: a case study of Lohaghat block, Champawat district, Uttarakhand, India

open access: yesDiscover Applied Sciences
This study investigates the geoelectrical properties of shallow aquifers and estimates their hydraulic parameters in the Lohaghat block of the Champawat district, Uttarakhand.
Somvir Singh, Nepal C. Mondal
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

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