Results 41 to 50 of about 485,769 (266)

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Water quality assessment of the Tano Basin in Ghana: a multivariate statistical approach

Applied Water Science, 2021
Multivariate statistical techniques including principal component and factor analyses were applied in this study to assess the quality of surface water from Tano basin in Ghana.
Samuel Obiri, Gloria Addico, Saada Mohammed, Wilson William Anku, Humphry Darko, Okrah Collins   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Hydrogeochemistry and its relationship with land use pattern and monsoon in hard rock aquifer

Applied Water Science
Influences of land use and monsoon recharge on groundwater geochemistry in the hard rock aquifer in south India are studied using geochemical modelling, geochemical and geospatial tools, and Pearson correlation analysis (PCA).
Natarajan Rajmohan, Mohanavelu Senthilkumar, Abdulaziz M. Alqarawy   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Ground water

Eos, Transactions American Geophysical Union, 1971
The demand for ground water has continued to increase during the period 1967–1970. An estimated 500,000 wells of all types are being drilled each year, further, as available surface water resources become increasingly more fully used, ground water represents an increasingly greater percentage of the total water resource being used.
openaire   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Sustainability of groundwater through community-driven distributed recharge: An analysis of arguments for water scarce regions of semi-arid India

Journal of Hydrology: Regional Studies, 2020
Study Region: Semi-Arid Regions of Marathawada, Vidarbha and Saurashtra in IndiaStudy Focus: To understand and evaluate the impact of Managed Aquifer Recharge (MAR) efforts.New Hydrological Insights for the Region: Since 1990, the Saurashtra region of ...
Praharsh M. Patel, Dipankar Saha, Tushaar Shah   +2 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Groundwater quality evaluation using hydrochemical and multivariate statistical techniques in Doiwala block, Dehradun District, Uttarakhand, India

Discover Geoscience
In the Doiwala block of the Dehradun District in Uttarakhand, groundwater serves as the main supply of irrigation and drinking water, however its quality may be threatened by human activity and population expansion.
Somvir Singh
doaj   +1 more source