Results 1 to 10 of about 1,880,201 (344)

An Experimental Group A Streptococcus Vaccine That Reduces Pharyngitis and Tonsillitis in a Nonhuman Primate Model

mBio, 2019
Group A Streptococcus (GAS) infections account for an estimated 500,000 deaths every year. This bacterial pathogen is responsible for a variety of mild and life-threatening infections and the triggering of chronic autoimmune sequelae.
Tania Rivera-Hernandez, Diane G. Carnathan, Scott Jones, Amanda J. Cork, Mark R. Davies, Peter M. Moyle, Istvan Toth, Michael R. Batzloff, James McCarthy, Victor Nizet, David Goldblatt, Guido Silvestri, Mark J. Walker   +12 more
doaj   +2 more sources

Group A Streptococcus

Hunter's Tropical Medicine and Emerging Infectious Diseases, 2019
Group A Streptococcus (GAS) or Streptococcus pyogenes, affects an estimated 800 million people each year. Most of the resulting estimated 639,000 annual deaths are related to rheumatic heart disease (RHD) and its complications. Resource-limited areas account for the vast majority of cases, although outbreaks still occur in industrialized countries. GAS
R. Hand, T. Snelling, J. Carapetis
semanticscholar   +2 more sources

Pathogenesis, epidemiology and control of Group A Streptococcus infection

Nature Reviews Microbiology, 2023
In this Review, Brouwer et al. summarize recent developments in our understanding of Group A Streptococcus (GAS), focusing on the epidemiologic and clinical features of GAS infection and the molecular mechanisms associated with GAS virulence and drug ...
Stephan Brouwer, Tania Rivera-Hernández, Bodie F. Curren, Nichaela Harbison-Price, David M. P. De Oliveira, Magnus G. Jespersen, M. Davies, M. Walker   +7 more
semanticscholar   +1 more source

State of the Art of Invasive Group A Streptococcus Infection in Children: A Scoping Review of the Literature with a Focus on Predictors of Invasive Infection

Children, 2023
Currently, it remains unclear why some children develop invasive group A Streptococcus (iGAS) and how to manage this condition. Therefore, to explore available works in the literature, we performed a scoping review aiming to analyze the current ...
Francesco Mariani, Carolina Gentili, Valentina Pulcinelli, Laura Martino, Piero Valentini, Danilo Buonsenso   +5 more
doaj   +1 more source

Host-dependent resistance of Group A Streptococcus to sulfamethoxazole mediated by a horizontally-acquired reduced folate transporter

Nature Communications, 2022
There is increasing evidence for metabolic processes mediating antimicrobial resistance. Here, the authors present a mechanism of sulfamethoxazole resistance in Group A Streptococcus that is dependent on acquiring end products of the host folate ...
M. K. D. Rodrigo, Aarti Saiganesh, Andrew J. Hayes, Alisha M. Wilson, Jack Anstey, Janessa L. Pickering, J. Iwasaki, J. Hillas, S. Winslow, Tabitha Woodman, P. Nitschke, J. Lacey, Karen J. Breese, M. P. van der Linden, P. Giffard, S. Tong, Nicola Gray, K. Stubbs, J. Carapetis, A. Bowen, M. Davies, T. C. Barnett   +21 more
semanticscholar   +1 more source

A brief review on Group A Streptococcus pathogenesis and vaccine development

Royal Society Open Science, 2021
Streptococcus pyogenes, also known as Group A Streptococcus (GAS), is a Gram-positive human-exclusive pathogen, responsible for more than 500 000 deaths annually worldwide. Upon infection, GAS commonly triggers mild symptoms such as pharyngitis, pyoderma
S. A. Castro, H. Dorfmueller
semanticscholar   +1 more source

The Indirect Impact of the SARS-CoV-2 Pandemic on Invasive Group a Streptococcus, Streptococcus Pneumoniae and Staphylococcus Aureus Infections in Houston Area Children

The Pediatric Infectious Disease Journal, 2021
Masking and social distancing have been adopted to mitigate the severe acute respiratory syndrome coronavirus 2 pandemic. We evaluated the indirect impact of severe acute respiratory syndrome coronavirus 2 prevention strategies on invasive Staphylococcus
J. McNeil, Anthony R. Flores, S. Kaplan, K. Hulten   +3 more
semanticscholar   +1 more source

Paediatrics: how to manage pharyngitis in an era of increasing antimicrobial resistance

Drugs in Context, 2021
The goal of this narrative review of pharyngitis is to summarize the practical aspects of the management of sore throat in children in high- and middle-income countries. A traditional review of the literature was performed.
Joan L Robinson
doaj   +1 more source

A Review of Streptococcus pyogenes: Public Health Risk Factors, Prevention and Control

Pathogens, 2021
Streptococcus pyogenes, (colloquially named “group A streptococcus” (GAS)), is a pathogen of public health significance, infecting 18.1 million people worldwide and resulting in 500,000 deaths each year.
Nelly Janira Avire, Harriet Whiley, Kirstin Ross   +2 more
doaj   +1 more source

Molecular Epidemiology of Group A Streptococcus Infections in The Gambia

Vaccines, 2021
Molecular epidemiological data on Group A Streptococcus (GAS) infection in Africa is scarce. We characterized the emm-types and emm-clusters of 433 stored clinical GAS isolates from The Gambia collected between 2004 and 2018.
Sona Jabang, A. Erhart, Saffiatou Darboe, Aru-Kumba Baldeh, Valérie Delforge, Gabriella Watson, E. Foster-Nyarko, Rasheed A Salaudeen, B. Lawal, G. Mackenzie, A. Botteaux, M. Antonio, P. Smeesters, on behalf of the MRCG StrepA Study Group   +13 more
semanticscholar   +1 more source