Results 101 to 110 of about 2,101,930 (408)

Mechanically Tunable Bone Scaffolds: In Vivo Hardening of 3D‐Printed Calcium Phosphate/Polycaprolactone Inks

Advanced Functional Materials, EarlyView.
A 3D bone scaffold with osteogenic properties and capable of hardening in vivo is developed. The scaffold is implanted in a ductile state, and a phase transformation of the ceramic induces the stiffening and strengthening of the scaffold in vivo. Abstract Calcium phosphate 3D printing has revolutionized customized bone grafting.
Miguel Mateu‐Sanz, Pablo Varela, Laura del‐Mazo‐Barbara, Irene Lodoso‐Torrecilla, Emilio Jiménez‐Piqué, Jordi Franch, Miguel Alaminos, Maria‐Pau Ginebra   +7 more
wiley   +1 more source

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Phylogenetic relationship of prophages is affected by CRISPR selection in Group A Streptococcus

BMC Microbiology, 2019
Background Group A Streptococcus (GAS) is a major human pathogen, which is associated with a wide spectrum of invasive diseases, such as pharyngitis, scarlet fever, rheumatic fever, and streptococcal toxic shock syndrome (STSS).
Shunsuke Yamada, Masaki Shibasaki, Kazunori Murase, Takayasu Watanabe, Chihiro Aikawa, Takashi Nozawa, Ichiro Nakagawa   +6 more
doaj   +1 more source

In vitro increased respiratory activity of selected oral bacteria may explain competitive and collaborative interactions in the oral microbiome [PDF]

, 2017
Understanding the driving forces behind the shifts in the ecological balance of the oral microbiota will become essential for the future management and treatment of periodontitis. As the use of competitive approaches for modulating bacterial outgrowth is
Boon, Nico, Hernandez Sanabria, Emma, Herrero, Esteban R, Kerckhof, Frederiek-Maarten, Slomka, Vera, Teughels, Wim, Zaidel, Lynette   +6 more
core   +3 more sources

Nanoparticles Decorated Nanotubes: Advanced Local Therapies From Anodized Nanoengineered Titanium Implants

Advanced Functional Materials, EarlyView.
This comprehensive review explores therapeutic titanium implants designed to enhance integration and provide superior antibacterial efficacy. It is focused on anodized titanium implants with titania nanotubes (TNTs) loaded with nanoparticles (NPs) for local therapeutic release, enhancing bioactivity and bactericidal functions.
Divya Chopra, Liwen Zhang, Tianqi Guo, Sašo Ivanovski, Ruirui Qiao, Karan Gulati   +5 more
wiley   +1 more source

Sharp increase in the incidence and severity of invasive Streptococcus pyogenes infections in children after the COVID-19 pandemic (2019-2023): A nationwide multicenter study

International Journal of Infectious Diseases
Objectives: A global surge in pediatric invasive group A streptococcal infection (iGAS) was reported after autumn 2022. This study analyzed the epidemiology and severity of iGAS in Spain, comparing two periods; P1: pre-outbreak (January 2019-September ...
Elvira Cobo-Vázquez, David Aguilera-Alonso, David Grandioso-Vas, Anna Gamell, Victoria Rello-Saltor, Manuel Oltra-Benavent, Eloisa Cervantes, Francisco Sanz-Santaeufemia, Jaime Carrasco-Colom, Ángela Manzanares-Casteleiro, Laura Martín-Pedraz, Eva Ramírez de Arellano, Lola Falcón-Neira, Leticia Martínez-Campos, Elena Colino-Gil, Beatriz Jiménez-Montero, Olga Calavia, Anna Hernandez-Ventura, Elena Del Castillo-Navío, Vanesa Matías-Del Pozo, Laura Calle-Miguel, Beatriz Soto, Berta Fernández, Filip Camil-Olteanu, Marta Pareja-León, Nuria López-Segura, Fátima Ara-Montojo, Beatriz Ruiz-Sáez, Cristina Calvo-Monge, María Sánchez-Códez, Teresa Reinoso, Katie Badillo, Carmen Vázquez, Pilar Villalón, Jesús Oteo-Iglesias, Isabel Mellado-Sola, Emilia Cercenado, Daniel Blázquez-Gamero, Ana Menasalvas, Maria José González-Abad, Borja Guarch, Mercedes Ibáñez-Alcalde, Begoña Carazo, Mayli Lung, Cristina Calvo, Jesús Saavedra-Lozano   +45 more
doaj   +1 more source

3D Differentiation of Bone‐Marrow Derived Mesenchymal Stromal Cells into the Keratocyte Lineage for Corneal Bioprinting

Advanced Healthcare Materials, EarlyView.
This study introduces a novel differentiation protocol for generating corneal stromal keratocyte‐like cells using drop‐on‐demand bioprinting and a collagen‐based hydrogel. The bioprinted constructs maintained a stable dome shape over 21 days while exhibiting upregulated CSK markers postdifferentiation.
Alexandre Taoum, Ronja Friede, Ole Thaden, Oleksandr Rachynskyi, Andrea Frank, Meng Wang, Friederike Dehli, Matthias Fuest, Daniela Duarte Campos   +8 more
wiley   +1 more source

Capsular Polysaccharide of Group A Streptococcus

Microbiology spectrum, 2019
Most clinical isolates of Streptococcus pyogenes elaborate a capsular polysaccharide, which is composed of hyaluronic acid, a high-molecular-mass polymer of alternating residues of N-acetyl glucosamine and glucuronic acid.
M. Wessels
semanticscholar   +1 more source

A Cryptic Non-Inducible Prophage Confers Phage-Immunity on the Streptococcus thermophilus M17PTZA496 [PDF]

, 2018
open9openda Silva Duarte, Vinícius; Giaretta, Sabrina; Campanaro, Stefano; Treu, Laura; Armani, Andrea; Tarrah, Armin; Oliveira de Paula, Sérgio; Giacomini, Alessio; Corich, Vivianada Silva Duarte, Vinícius; Giaretta, Sabrina; Campanaro, Stefano; Treu ...

core   +1 more source

Conditioned Media from Mechanically Stimulated Macrophages Upregulate Osteogenic Genes in Human Mesenchymal Stromal Cells

Advanced Healthcare Materials, EarlyView.
Bone fracture healing is a complex, timely orchestrated scenario involving multiple cell types and a plethora of cytokines and regulatory factors. To gain further insight, an in vitro model to a) study macrophage polarization under mechanical load in a fibrin hydrogel and b) subsequently assess the effect of conditioned media derived from macrophages ...
Anne Géraldine Guex, Ursula Menzel, Yann Ladner, Angela R. Armiento, Martin J. Stoddart   +4 more
wiley   +1 more source