Results 51 to 60 of about 1,880,201 (344)

Detection of epidemic scarlet fever group A Streptococcus in Australia.

Clinical Infectious Diseases, 2019
Sentinel hospital surveillance was instituted in Australia to detect the presence of pandemic group A Streptococcus strains causing scarlet fever. Genomic and phylogenetic analyses indicated the presence of an Australian GAS emm12 scarlet fever isolate ...
M. Walker, Stephan Brouwer, B. Forde, Kate A Worthing, Liam McIntyre, L. Sundac, S. Maloney, Leah W. Roberts, T. C. Barnett, Johanna Richter, A. J. Cork, A. Irwin, Yuan-hai You, Jianzhong Zhang, G. Dougan, K. Yuen, V. Nizet, S. Beatson, K. Grimwood, M. Davies   +19 more
semanticscholar   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

β-HEMOLYTIC STREPTOCOCCUS GROUP A CARRIER IN CHILDREN: THE PROBLEM OF DIFFERENTIAL DIAGNOSIS

Детские инфекции (Москва), 2018
Streptococcal infection is characterized by a variety of manifestations from asymptomatic carriage of the pathogen to manifest forms. Recently, in addition to the bacteriological method for confirming streptococcal etiology, the rapid test for β ...
E. V. Novosad, S. L. Bevza, N. M. Obolskaya, O. V. Shamsheva, V. V. Belimenko   +4 more
doaj   +1 more source

Mucosal Immunization Has Benefits over Traditional Subcutaneous Immunization with Group A Streptococcus Antigens in a Pilot Study in a Mouse Model

Vaccines, 2023
Group A Streptococcus (GAS) is a major human pathogen for which there is no licensed vaccine. To protect against infection, a strong systemic and mucosal immune response is likely to be necessary to prevent initial colonization and any events that might ...
Helen Alexandra Shaw, Alex Remmington, Giselle McKenzie, Caroline Winkel, Fatme Mawas   +4 more
doaj   +1 more source

Rapid antigen detection test for group A streptococcus in children with pharyngitis.

Cochrane Database of Systematic Reviews, 2016
BACKGROUND Group A streptococcus (GAS) accounts for 20% to 40% of cases of pharyngitis in children; the remaining cases are caused by viruses. Compared with throat culture, rapid antigen detection tests (RADTs) offer diagnosis at the point of care ...
Jérémie F. Cohen, N. Bertille, R. Cohen, M. Chalumeau   +3 more
semanticscholar   +1 more source

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source

Beta-Haemolytic Group A, C and G Streptococcal Infections in Southern Hungary: A 10-Year Population-Based Retrospective Survey (2008–2017) and a Review of the Literature

Infection and Drug Resistance, 2020
Márió Gajdács,1 Marianna Ábrók,2 Andrea Lázár,2 Katalin Burián2,3 1Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Szeged 6720, Hungary; 2Institute of ...
Gajdács M, Ábrók M, Lázár A, Burián K   +3 more
doaj  

Virulence Role of the GlcNAc Side Chain of the Lancefield Cell Wall Carbohydrate Antigen in Non-M1-Serotype Group A Streptococcus

mBio, 2018
Classification of streptococci is based upon expression of unique cell wall carbohydrate antigens. All serotypes of group A Streptococcus (GAS; Streptococcus pyogenes), a leading cause of infection-related mortality worldwide, express the group A ...
Anna Henningham, Mark R. Davies, Satoshi Uchiyama, Nina M. van Sorge, Sean Lund, Kelsey T. Chen, Mark J. Walker, Jason N. Cole, Victor Nizet   +8 more
doaj   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Group A Streptococcus (GAS) causes invasive streptococcal infections in humans, resulting in high mortality. Thus, GAS is also known as “killer bacteria” or “flesh-eating bacteria.” The mechanism by which the immune system recognizes this ...
Takashi Imai, T. Matsumura, S. Mayer-Lambertz, C. Wells, E. Ishikawa, S. Butcher, T. C. Barnett, M. Walker, A. Imamura, H. Ishida, T. Ikebe, T. Miyamoto, M. Ato, S. Ohga, B. Lepenies, N. V. van Sorge, S. Yamasaki   +16 more
semanticscholar   +1 more source