Results 61 to 70 of about 116,012,081 (309)

Genetic Switch to Hypervirulence Reduces Colonization Phenotypes of the Globally Disseminated Group A Streptococcus M1T1 Clone

, 2020
Background. The recent resurgence of invasive group A streptococcal disease has been paralleled by the emergence of the M1T1 clone. Recently, invasive disease initiation has been linked to mutations in the covR/S 2-component regulator.
Streptococcus, Jid, • Clone, A Group
core  

Maternal and Neonatal Colonisation of Group B Streptococcus at Muhimbili National Hospital in Dar es Salaam, Tanzania: Prevalence, Risk Factors and Antimicrobial Resistance. [PDF]

, 2009
Group B streptococcus (GBS), which asymptomatically colonises the vaginal and rectal areas of women, is the leading cause of septicemia, meningitis and pneumonia in neonates. In Tanzania no studies have been done on GBS colonisation of pregnant women and
Joachim Agricola, Joachim, Agricola, Massawe, Furaha A, Lyamuya Eligius F, Mecky I Matee, Lyamuya, Eligius F, Eligius F Lyamuya, Matee Mecky I, Joachim, A., Agricola Joachim, Furaha A Massawe, Lyamuya, E.F., Matee, Mecky I, Matee, M.I., Massawe, F.A., Massawe Furaha A   +15 more
core   +2 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Treatment of acute pharyngitis in children: an Italian intersociety consensus (SIPPS-SIP-SITIP-FIMP-SIAIP-SIMRI-FIMMG)

Italian Journal of Pediatrics
Sore throat represents one of the main causes of antibiotic overprescription in children. Its management is still a matter of debate, with countries considering streptococcal pharyngotonsillitis a benign and self-limiting condition and others advocating ...
Elena Chiappini, Giovanni Simeone, Marcello Bergamini, Roberta Pellegrino, Alfredo Guarino, Annamaria Staiano, Susanna Esposito, Guido Castelli Gattinara, Andrea Lo Vecchio, Stefania Stefani, Iride Dello Iacono, Immacolata Scotese, Giovanna Tezza, Giulio Dinardo, Simona Riccio, Sofia Pellizzari, Sonia Iavarone, Giulia Lorenzetti, Elisabetta Venturini, Daniele Donà, Luca Pierantoni, Mattia Doria, Silvia Garazzino, Fabio Midulla, Claudio Cricelli, Luigi Terracciano, Annalisa Capuano, Eugenia Bruzzese, Daniele Ghiglioni, Lara Fusani, Eleonora Fusco, Paolo Biasci, Lamberto Reggiani, Luigi Matera, Enrica Mancino, Elisa Barbieri, Antonio D’Avino, Laura Cursi, Maria Giuseppa Sullo, Silvestro Scotti, Gian Luigi Marseglia, Giuseppe Di Mauro, Nicola Principi, Luisa Galli, Maria Carmen Verga   +44 more
doaj   +1 more source

Emergence of respiratory Streptococcus agalactiae isolates in cystic fibrosis patients [PDF]

, 2009
Streptococcus agalactiae is a well-known pathogen for neonates and immunocompromized adults. Beyond the neonatal period, S. agalactiae is rarely found in the respiratory tract. During 2002–2008 we noticed S. agalactiae in respiratory secretions of 30/185
Vera Eickel, Brandt Claudia, Kahl, Barbara, Barbara Spellerberg, Reinisch Beatrice, Eickel, Vera, Angelika Dübbers, Eickel Vera, Peter Küster, Dübbers, Angelika, Brandt, Claudia, Küster Peter, Reinisch, Beatrice, Beatrice Reinisch, Dübbers Angelika, Spellerberg Barbara, Küster, Peter, Kahl Barbara, Barbara Kahl, Claudia Brandt, Spellerberg, Barbara   +20 more
core   +1 more source

Metabolic and Fluid Biomarkers Support Microglia Activation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis is an incurable neurodegenerative disease involving motor neuron degeneration and metabolic and immune dysfunction. We combined clinical data, cerebrospinal fluid biomarkers and fluorodeoxyglucose positron emission tomography with magnetic resonance imaging to investigate the role of reactive microglia in disease ...
Matteo Zanovello, Francesca Serani, Alen Bebeti, Federica Paredi, Giulia Quadrio, Andrea Fortuna, Giacomo Maria Minicuci, Elena Pegoraro, Annachiara Cagnin, Diego Cecchin, Gianni Sorarù   +10 more
wiley   +1 more source

Prevalent emm Types among Invasive GAS in Europe and North America since Year 2000

Frontiers in Public Health, 2018
BackgroundStreptococcus pyogenes or group A streptococcus (GAS) is an important human pathogen responsible for a broad range of infections, from uncomplicated to more severe and invasive diseases with high mortality and morbidity.
Giovanni Gherardi, Luca Agostino Vitali, Roberta Creti   +2 more
doaj   +1 more source

Contribution of fibronectin-binding protein to pathogenesis of Streptococcus suis serotype 2 [PDF]

, 2002
In the present study we investigated the role of the fibronectin (FN)- and fibrinogen (FGN)-binding protein (FBPS) in the pathogenesis of Streptococcus suis serotype 2 in piglets. The complete gene encoding FBPS from S.
Dijkstra, J., Smit, H.E., Verhaar, R., Alphen, L., van, Greeff, A., de, Robin Verhaar, Loek van Alphen, Herma Buys, Buys, H., Janny Dijkstra, Hilde E. Smith, Astrid de Greeff   +11 more
core   +1 more source

Invasive Group A Streptococcus Infection among Children, Rural Kenya

Emerging Infectious Diseases, 2016
To determine the extent of group A Streptococcus (GAS) infections in sub-Saharan Africa and the serotypes that cause disease, we analyzed surveillance data for 64,741 hospital admissions in Kilifi, Kenya, during 1998–2011.
Anna C. Seale, Mark R. Davies, Kirimi Anampiu, Susan C. Morpeth, Sammy Nyongesa, Salim Mwarumba, Pierre R. Smeesters, Androulla Efstratiou, Rosylene Karugutu, Neema Mturi, Thomas N. Williams, J. Anthony G. Scott, Samuel Kariuki, Gordon Dougan, James A. Berkley   +14 more
doaj   +1 more source

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source