Results 51 to 60 of about 116,012,081 (309)

Virulence Role of the GlcNAc Side Chain of the Lancefield Cell Wall Carbohydrate Antigen in Non-M1-Serotype Group A Streptococcus

mBio, 2018
Classification of streptococci is based upon expression of unique cell wall carbohydrate antigens. All serotypes of group A Streptococcus (GAS; Streptococcus pyogenes), a leading cause of infection-related mortality worldwide, express the group A ...
Anna Henningham, Mark R. Davies, Satoshi Uchiyama, Nina M. van Sorge, Sean Lund, Kelsey T. Chen, Mark J. Walker, Jason N. Cole, Victor Nizet   +8 more
doaj   +1 more source

Identification and characterization of two temperature-induced surface-associated proteins of Streptococcus suis with high homologies to members of the arginine deiminase system of Streptococcus pyogenes [PDF]

, 2002
The present study was performed to identify stress-induced putative virulence proteins of Streptococcus suis. For this, protein expression patterns of streptococci grown at 32, 37, and 42°C were compared by one- and two-dimensional gel electrophoresis ...
Gruening, P., Smith, H.E., Winterhoff, N., Valentin-Weigand, P., Goethe, R., Kalisz, H., Rohde, M.   +6 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Streptococcus equi subsp. equi and Streptococcus equi subsp. zooepidemicus [PDF]

, 2013
The bacterium Streptococcus equi subsp. equi (S. equi) is the causative agent of the highly contagious upper respiratory disease "strangles" in horses. The ancestor of S. equi, Streptococcus equi subsp. zooepidemicus (S.
Lindahl, Susanne
core   +1 more source

β-HEMOLYTIC STREPTOCOCCUS GROUP A CARRIER IN CHILDREN: THE PROBLEM OF DIFFERENTIAL DIAGNOSIS

Детские инфекции (Москва), 2018
Streptococcal infection is characterized by a variety of manifestations from asymptomatic carriage of the pathogen to manifest forms. Recently, in addition to the bacteriological method for confirming streptococcal etiology, the rapid test for β ...
E. V. Novosad, S. L. Bevza, N. M. Obolskaya, O. V. Shamsheva, V. V. Belimenko   +4 more
doaj   +1 more source

VEGF-Mediated Augmentation of Autophagic and Lysosomal Activity in Endothelial Cells Defends against Intracellular Streptococcus pyogenes

mBio, 2022
Group A Streptococcus (GAS), a deleterious human-pathogenic bacterium, causes life-threatening diseases such as sepsis and necrotic fasciitis. We recently reported that GAS survives and replicates within blood vessel endothelial cells because these cells
Shiou-Ling Lu, Hiroko Omori, Yi Zhou, Yee-Shin Lin, Ching-Chuan Liu, Jiunn-Jong Wu, Takeshi Noda   +6 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis. [PDF]

, 2015
Streptococcus suis causes disease in pigs worldwide and is increasingly implicated in zoonotic disease in East and South-East Asia. To understand the genetic basis of disease in S.
Schultsz, C, Langford, P.R., Maglennon, Gareth A, Campbell, J., Wang, J., Chieu, T.T.B., Tran, TBC, Wren, B.W., Hoa, N.T., Tucker, Alexander W, Corander, Jukka, Corander, J., Ngo Thi, H, Schultsz, Constance, Valimaki, N, Wren, BW, Schultsz, C., Farrar, Jeremy, Holden, M T G, Wren, B W, Baker, S., Peters, Sarah E., Wang, Jinhong, Jombart, T., Maskell, DJ, Cuccui, Jon, Vehkala, Minna, Chaudhuri, RR, Chieu, TTB, Campbell, James, Rycroft, Andrew N, Campbell, J, Weinert, Lucy A, Wren, Brendan W, BRaDP1T Consortium, Chaudhuri, R R, Wang, J, Chaudhuri, Roy R, Terra, Vanessa, Chieu, Tran Thi Bich, Baig, Abiyad, Rycroft, A N, Nguyen, VVC, Howell, Kate J, Parkhill, Julian, Maskell, D J, Bentley, S D, Chaudhuri, R.R., Chau, N.V.V., Howell, Kate J., Baker, Stephen, Valimaki, N., Jombart, Thibaut, Baker, S, Ngo Thi Hoa, Tucker, AW, Weinert, LA, Ngo, TH, Baig, A., Peters, S.E., Rycroft, A.N., Tucker, A.W., Holden, Matthew T G, Tucker, Alexander W., Chau, Nguyen Van Vinh, Howell, K.J., Peters, SE, Vehkala, M, Parkhill, J, Matthews, Dominic, Vehkala, M., Peters, S E, Bentley, Stephen D, Harris, D., Langford, PR, Chaudhuri, Roy R., Bentley, Stephen D., Holden, Matthew T. G., Tran Thi Bich Chieu, Nguyen, Van Vinh Chau, Baig, A, Farrar, J, Corander, J, Li, Yanwen, Langford, Paul R, Holden, M.T.G., Weinert, Lucy A., Bosse, Janine T, Jombart, T, Välimäki, Niko, Bentley, S.D., Holden, MTG, Tran, Thi Bich Chieu, Maskell, Duncan J, Hoa, NT, Rycroft, Andrew N., Rycroft, AN, Tucker, A W, Maskell, Duncan J., Langford, Paul R., Bentley, SD, Peters, Sarah E, Holden, Matthew TG, Howell, K J, Farrar, J., Parkhill, J., Wren, Brendan W., Weinert, L.A., Nguyen Van Vinh Chau, Maskell, D.J., BRaDP1T Consortium,, Hoa, Ngo Thi, Van Vinh Chau, Nguyen, Weinert, L A, Howell, KJ, Nguyen Van Vinh, C, Harris, D, Langford, P R, Van Vinh Chau, N, Harris, David, Tran Thi Bich, C, Vaelimaeki, N   +121 more
core   +6 more sources

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Mucosal Immunization Has Benefits over Traditional Subcutaneous Immunization with Group A Streptococcus Antigens in a Pilot Study in a Mouse Model

Vaccines, 2023
Group A Streptococcus (GAS) is a major human pathogen for which there is no licensed vaccine. To protect against infection, a strong systemic and mucosal immune response is likely to be necessary to prevent initial colonization and any events that might ...
Helen Alexandra Shaw, Alex Remmington, Giselle McKenzie, Caroline Winkel, Fatme Mawas   +4 more
doaj   +1 more source