Results 121 to 130 of about 18,689,161 (353)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Multitask feature selection within structural datasets

Data-Centric Engineering
Population-based structural health monitoring (PBSHM) systems use data from multiple structures to make inferences of health states. An area of PBSHM that has recently been recognized for potential development is the use of multitask learning (MTL ...
Sarah Bee, Jack Poole, Keith Worden, Nikolaos Dervilis, Lawrence Bull   +4 more
doaj   +1 more source

haller-group/SSMLearn: Version 1.0

<h2>What's Changed</h2> <ul> <li>added nonsmooth examples by @leonardobettini in https://github.com/haller-group/SSMLearn/pull/1</li> </ul> <h2>New Contributors</h2> <ul> <li>@leonardobettini ...
Haller Group, Nonlinear Dynamics, Bálint Kaszás, Leonardo Bettini, Mattia Cenedese, Joar Axås   +4 more
core   +1 more source

From integration to competition: Britain, Germany and the EU's new group dynamics. EPIN Commentary No. 10, 30 April 2012 [PDF]

, 2012
Sociological research on group dynamics highlights how easily the EU, originally set up to pursue closer integration, might become an arena for competition for ‘dominance’ between its members.
Parkes, Roderick
core  

Goal commitment and alignment of personal goals predict group identification only when the goals are shared

, 2011
Selfish pursuits of personal goals in group contexts may conflict with the group goal. Drawing on the shared reality theory and the intersubjective consensus approach to cultural dynamics, however, we propose that commitment to personal goals would be ...
Chi-yue Chiu, Yan Zhang, Zhang, Yan, Chiu, Chi-yue   +3 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

In silico identification and characterisation of pathogenic genetic variants (nsSNPs) in the eukaryotic initiation factors eIF2 and eIF2B affecting miRNA binding sites

Egyptian Journal of Medical Human Genetics
Background The eukaryotic translation initiation factors (eIF2 and eIF2B) are known to play a regulatory role in translation initiation. Studies have indicated that several missense mutations in both eIF2 and eIF2B subunits can lead to severe ...
Pavan K. Madasu, V. Lokesh Subrahmanyam, Thyageshwar Chandran   +2 more
doaj   +1 more source

Stability in flux: group dynamics in evolving networks (Abstract)

, 2010
From Facebook groups and online gaming clans, to social movements and terrorist cells, groups of individuals aligned by interest, values or background are of increasing interest to social network researchers.
Funk, Sebastian, Bullock, Seth, Bryden, John, Jansen, Vincent, Geard, Nicholas   +4 more
core