Results 101 to 110 of about 18,689,161 (353)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
A group dynamics framework for 21st century collective intelligence facilitators
, 2020 First paragraph: Systems thinking and collective action capabilities are increasingly needed to address societal challenges (Hogan, Harney, & Broome, 2015; Mulgan, 2018).
Mike Moroney +31 more
core +1 more source
Group interplay and dynamics in UN Disarmament Forums: In Search of Consensus [PDF]
, 2017 The elimination of nuclear weapons has been an objective of the United Nations (UN) since 1946. Although addressed through multiple forums, including the UN General Assembly's First Committee, Conference on Disarmament and the Nuclear Non-Proliferation ...
Dee, Megan
core +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Nature Communications, 2018 Chromosome instability is associated with cancer formation. Here the authors identify in cultured human cancer cells a non-canonical DNA bridge breakage pathway leading to chromosome missegregation and rearrangements triggered by sister DNA ...
Ankana Tiwari +2 more
doaj +1 more source
Chaotic micromixing in open wells using audio-frequency acoustic microstreaming
BioTechniques, 2009 Mixing fluids for biochemical assays is problematic when volumes are very small (on the order of the 10 µL typical of single drops), which has inspired the development of many micromixing devices.
Karolina Petkovic-Duran +3 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Frontiers in ImmunologyIntroductionNon-clinical immunogenicity yields valuable insights into pharmacokinetics, efficacy, and safety. Given the complex nature of ADC therapeutics, early detection of anti-drug antibodies (ADAs) is critical for elucidating exposure and toxicity ...
Runzhong Fu +7 more
doaj +1 more source
Mechanisms of transcriptional regulation of ecdysone response
Вавиловский журнал генетики и селекции, 2019 The mechanisms of ecdysone-dependent expression have been studied for many decades. Initially, the activation of individual genes under the influence of ecdysone was studied on the model of polythene chromosomes from salivary glands of Drosophila ...
M. Yu. Mazina, N. E. Vorobyeva
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source