Results 81 to 90 of about 13,685,848 (310)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Antea Group Archeologie 2018/153

, 2014
In september 2018 heeft Antea Group in opdracht van CroonenBuro5 een archeologisch booronderzoek (verkennende fase) uitgevoerd voor een plangebied dat valt binnen het grotere bestemmingsplan Slotjes te Oosterhout. Het plangebied bestaat uit verschillende
Arkema, Drs. M. (Antea Group), Teekens, Drs. P. (Antea Group), Riddersma, F.S. (Antea Group), Researcher, Fens, Drs. R.L. (Antea Group), Researcher, Fens, MA R.L. (Antea Group), Researcher, Fens, R.L. (Antea Group), Researcher, Teekens, P.C. (Antea Group), Researcher, Fens, MA RL (Antea Group), Fens, Drs. R. (Antea Group), Fens, R.L. (Antea Group), ProjectMember, Looveren, V Van (Antea Group), Fens, MA R.L. (Antea Group), Editor, Fens, drs. RL (Antea Group), Pels-Ouweneel, Drs. A. (Antea Group), Sophie, Drs. G. (Antea Group), Colijn, MA J.E. (Antea Group), Fens, drs. R.L. (Antea Group), Munster, Drs. B. van (Antea Group), La Fèber, drs. D.J. (Antea Group), Fens, R. (Antea Group), Researcher, Nater, MA C.I. (Antea Group), Dasselaar, MA M. van (Antea Group), Fèber, D. la (Antea Group), Nater, MSC C.I. (Antea Group), Looveren, Drs. V. van (Antea Group), Fens, MA R. (Antea Group), Arkema, MA M. (Antea Group), Fèber, Drs. D. la (Antea Group), Fens, drs RL (Antea Group), Tolsma, drs. J. (Antea Group), Riddersma, F. (Antea Group), Researcher, Veen, V van der (Antea Group), Vossen, Drs. I. (Antea Group), Teekens, Drs. P.C. (Antea Group), Colijn, J.E. (Antea Group), Sophie, drs. G.J.A. (Antea Group), Bostelen, Drs. T. van (Antea Group), Fens, R.L. (Antea Group), RelatedPerson, Arkema, M.H. (Antea Group), Akkerman, E. (Antea Group), Fèber, drs D.J. la (Antea Group), Looveren, MA V. van (Antea Group), Fèber, drs. D.J. la (Antea Group), Sophie, MA G. (Antea Group), Craane, Dr. M.L. (Antea Group), M.H. Arkema, M. Arkema, I. Vossen, V van der Veen, M. van Dasselaar, T. van Bostelen, V. van Looveren, G.J.A. Sophie, G. Sophie, E. Akkerman, F. Riddersma, A. Pels-Ouweneel, J.E. Colijn, R. Fens, M.L. Craane, R.L. Fens, RL Fens, J. Tolsma, P. Teekens, D. la Fèber, D.J. la Fèber, B. van Munster, F.S. Riddersma, P.C. Teekens, C.I. Nater, V Van Looveren   +70 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Modelling airport passenger group dynamics using an agent-based method [PDF]

, 2014
This thesis investigates the influence of passenger group dynamics on passengers' behaviour in an international airport. A simulation model is built to analyse passengers' behaviour during airport departure processes and during an emergency event ...
Cheng, Lin
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Lipid gating of BK channels and activation mechanism by negatively charged lipids

Communications Chemistry
BK channels are a class of K+ channels that possess an unusually high conductance and are synergistically gated by intracellular Ca2+ and voltage. Despite the significant array of experimental and computational data, many aspects of their function and ...
Andrei Mironenko, Bert L. de Groot, Wojciech Kopec   +2 more
doaj   +1 more source

Control of Smc Coiled Coil Architecture by the ATPase Heads Facilitates Targeting to Chromosomal ParB/parS and Release onto Flanking DNA

Cell Reports, 2016
Smc/ScpAB promotes chromosome segregation in prokaryotes, presumably by compacting and resolving nascent sister chromosomes. The underlying mechanisms, however, are poorly understood.
Anita Minnen, Frank Bürmann, Larissa Wilhelm, Anna Anchimiuk, Marie-Laure Diebold-Durand, Stephan Gruber   +5 more
doaj   +1 more source

Group dynamics and sustainability.

, 2021
Group dynamics and sustainability.
Yashodha (9444775), Judit Johny (11292438), Prakashan Chellattan Veettil (11292435)   +2 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Antea Group Archeologie 2018/156

, 2019
N.B.: Dit onderzoek is voorgelegd aan de opdrachtgever, maar niet aan de bevoegde overheid. In oktober 2018 heeft Antea Group een archeologisch onderzoek uitgevoerd voor het plangebied van de gasleiding te Waalwijk, gemeente Waalwijk.
Koopmanschap, H.J.L.C. (Antea Group), Fleuren, I. (Antea Group), I. Fleuren, H.J.L.C. Koopmanschap   +3 more
core   +1 more source