Results 71 to 80 of about 18,689,161 (353)

Automatic Kernel Selection for Gaussian Processes Regression with Approximate Bayesian Computation and Sequential Monte Carlo

Frontiers in Built Environment, 2017
The current work introduces a novel combination of two Bayesian tools, Gaussian Processes (GPs), and the use of the Approximate Bayesian Computation (ABC) algorithm for kernel selection and parameter estimation for machine learning applications.
Anis Ben Abdessalem, Nikolaos Dervilis, David J. Wagg, Keith Worden   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Personality processes and intra-group dynamics in sports teams [PDF]

, 2008
Can a better understanding of group dynamics raise individual and team athletic performance or improve the outcomes of exercise interventions? Much human behaviour in sport and exercise settings is embedded within groups where individuals’ cognitions ...
Beauchamp, Mark R, Lavallee, David, Jackson, Ben   +2 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Proposal for demonstration of long-range cluster state entanglement in the presence of photon loss

APL Photonics, 2017
Photonic cluster states are a crucial resource for optical quantum computing. Recently a quantum dot single photon source has been demonstrated to produce strings of single photons in a small linear cluster state.
Thomas Nutz, Antony Milne, Pete Shadbolt, Terry Rudolph   +3 more
doaj   +1 more source

Interactions between the discoidin domain receptor 1 and β1 integrin regulate attachment to collagen

Biology Open, 2013
Summary Collagen degradation by phagocytosis is essential for physiological collagen turnover and connective tissue homeostasis. The rate limiting step of phagocytosis is the binding of specific adhesion receptors, which include the integrins and ...
Lisa A. Staudinger, Stephen J. Spano, Wilson Lee, Nuno Coelho, Dhaarmini Rajshankar, Michelle P. Bendeck, Tara Moriarty, Christopher A. McCulloch   +7 more
doaj   +1 more source

Structural basis for promiscuous action of monoterpenes on TRP channels

Communications Biology, 2021
Thi Hong Dung Nguyen et al. identify which regions within TRP channels TRPV1 and TRPV3 confer their sensitivity to monoterpenes that are major constituents of plant-derived essential oils.
Thi Hong Dung Nguyen, Satoru G. Itoh, Hisashi Okumura, Makoto Tominaga   +3 more
doaj   +1 more source

Probing Methyl Group Dynamics in Proteins by NMR Cross-Correlated Dipolar Relaxation and Molecular Dynamics Simulations

, 2022
Nuclear magnetic resonance (NMR) spin relaxation is the most informative approach to experimentally probe the internal dynamics of proteins on the picosecond to nanosecond timescale.
Frans A. A., Mulder, Lars V., Schäfer, Ahmed A. A. I., Ali, Falk, Hoffmann   +3 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A non-stationary bias adjustment method for improving the inter-annual variability and persistence of projected precipitation

Scientific Reports
Hydrological studies depend heavily on environmental variables, such as precipitation and resulting runoff, which exhibit highly seasonal and intermittent behaviour in semiarid basins.
Marina Cantalejo, Manuel Cobos, Agustín Millares, Asunción Baquerizo   +3 more
doaj   +1 more source