Results 51 to 60 of about 16,336,006 (343)

Automatic Kernel Selection for Gaussian Processes Regression with Approximate Bayesian Computation and Sequential Monte Carlo

Frontiers in Built Environment, 2017
The current work introduces a novel combination of two Bayesian tools, Gaussian Processes (GPs), and the use of the Approximate Bayesian Computation (ABC) algorithm for kernel selection and parameter estimation for machine learning applications.
Anis Ben Abdessalem, Nikolaos Dervilis, David J. Wagg, Keith Worden   +3 more
doaj   +1 more source

Testing the Efficacy of OurSpace, a Brief, Group Dynamics-Based Physical Activity Intervention: A Randomized Controlled Trial

Journal of Medical Internet Research, 2016
Background Emerging technologies (ie, mobile phones, Internet) may be effective tools for promoting physical activity (PA). However, few interventions have provided effective means to enhance social support through these platforms.
Brandon Irwin, D. Kurz, Patrice Chalin, Nicholas Thompson   +3 more
semanticscholar   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Proposal for demonstration of long-range cluster state entanglement in the presence of photon loss

APL Photonics, 2017
Photonic cluster states are a crucial resource for optical quantum computing. Recently a quantum dot single photon source has been demonstrated to produce strings of single photons in a small linear cluster state.
Thomas Nutz, Antony Milne, Pete Shadbolt, Terry Rudolph   +3 more
doaj   +1 more source

Interactions between the discoidin domain receptor 1 and β1 integrin regulate attachment to collagen

Biology Open, 2013
Summary Collagen degradation by phagocytosis is essential for physiological collagen turnover and connective tissue homeostasis. The rate limiting step of phagocytosis is the binding of specific adhesion receptors, which include the integrins and ...
Lisa A. Staudinger, Stephen J. Spano, Wilson Lee, Nuno Coelho, Dhaarmini Rajshankar, Michelle P. Bendeck, Tara Moriarty, Christopher A. McCulloch   +7 more
doaj   +1 more source

Structural basis for promiscuous action of monoterpenes on TRP channels

Communications Biology, 2021
Thi Hong Dung Nguyen et al. identify which regions within TRP channels TRPV1 and TRPV3 confer their sensitivity to monoterpenes that are major constituents of plant-derived essential oils.
Thi Hong Dung Nguyen, Satoru G. Itoh, Hisashi Okumura, Makoto Tominaga   +3 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

A non-stationary bias adjustment method for improving the inter-annual variability and persistence of projected precipitation

Scientific Reports
Hydrological studies depend heavily on environmental variables, such as precipitation and resulting runoff, which exhibit highly seasonal and intermittent behaviour in semiarid basins.
Marina Cantalejo, Manuel Cobos, Agustín Millares, Asunción Baquerizo   +3 more
doaj   +1 more source

Non-adiabatic Mapping Dynamics in the Phase Space of the SU(N) Lie Group [PDF]

, 2022
Duncan Bossion, Wenxiang Ying, Sutirtha N. Chowdhury, Pengfei Huo   +3 more
openalex   +1 more source