Results 51 to 60 of about 3,905,348 (276)

Fission-fusion dynamics and group-size dependent composition in heterogeneous populations

, 2019
Many animal groups are heterogeneous and may even consist of individuals of different species, called mixed-species flocks. Mathematical and computational models of collective animal movement behaviour, however, typically assume that groups and ...
Guttal, Vishwesha, Iyer, Srikanth K., Nair, Gokul G., Senthilnathan, Athmanathan   +3 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

STAG2 loss in Ewing sarcoma alters enhancer-promoter contacts dependent and independent of EWS::FLI1

EMBO Reports
Cohesin complexes carrying STAG1 or STAG2 organize the genome into chromatin loops. STAG2 loss-of-function mutations promote metastasis in Ewing sarcoma, a pediatric cancer driven by the fusion transcription factor EWS::FLI1. We integrated transcriptomic
Daniel Giménez-Llorente, Ana Cuadrado, María José Andreu, Inmaculada Sanclemente-Alamán, Maria Solé-Ferran, Miriam Rodríguez-Corsino, Ana Losada   +6 more
doaj   +1 more source

Temporal pairwise spike correlations fully capture single-neuron information

Nature Communications, 2016
To understand the neural code it is important to determine what spiking features contain the relevant information. Here, the authors use mathematical approaches to show that two pair-wise correlation functions, the autocorrelation function within spike ...
Amadeus Dettner, Sabrina Münzberg, Tatjana Tchumatchenko   +2 more
doaj   +1 more source

Automatic Kernel Selection for Gaussian Processes Regression with Approximate Bayesian Computation and Sequential Monte Carlo

Frontiers in Built Environment, 2017
The current work introduces a novel combination of two Bayesian tools, Gaussian Processes (GPs), and the use of the Approximate Bayesian Computation (ABC) algorithm for kernel selection and parameter estimation for machine learning applications.
Anis Ben Abdessalem, Nikolaos Dervilis, David J. Wagg, Keith Worden   +3 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Structural basis for promiscuous action of monoterpenes on TRP channels

Communications Biology, 2021
Thi Hong Dung Nguyen et al. identify which regions within TRP channels TRPV1 and TRPV3 confer their sensitivity to monoterpenes that are major constituents of plant-derived essential oils.
Thi Hong Dung Nguyen, Satoru G. Itoh, Hisashi Okumura, Makoto Tominaga   +3 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Proposal for demonstration of long-range cluster state entanglement in the presence of photon loss

APL Photonics, 2017
Photonic cluster states are a crucial resource for optical quantum computing. Recently a quantum dot single photon source has been demonstrated to produce strings of single photons in a small linear cluster state.
Thomas Nutz, Antony Milne, Pete Shadbolt, Terry Rudolph   +3 more
doaj   +1 more source