Results 61 to 70 of about 3,905,348 (276)

Interactions between the discoidin domain receptor 1 and β1 integrin regulate attachment to collagen

Biology Open, 2013
Summary Collagen degradation by phagocytosis is essential for physiological collagen turnover and connective tissue homeostasis. The rate limiting step of phagocytosis is the binding of specific adhesion receptors, which include the integrins and ...
Lisa A. Staudinger, Stephen J. Spano, Wilson Lee, Nuno Coelho, Dhaarmini Rajshankar, Michelle P. Bendeck, Tara Moriarty, Christopher A. McCulloch   +7 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

A non-stationary bias adjustment method for improving the inter-annual variability and persistence of projected precipitation

Scientific Reports
Hydrological studies depend heavily on environmental variables, such as precipitation and resulting runoff, which exhibit highly seasonal and intermittent behaviour in semiarid basins.
Marina Cantalejo, Manuel Cobos, Agustín Millares, Asunción Baquerizo   +3 more
doaj   +1 more source

Individual and Group Dynamics in Purchasing Activity

, 2010
As a major part of the daily operation in an enterprise, purchasing frequency is of constant change. Recent approaches on the human dynamics can provide some new insights into the economic behaviors of companies in the supply chain.
Bagler, Barabási, Blanchard, Brockmann, Cajueiro, Caldarelli, Chao Fan, Dezsö, Gabrielli, Gonçalves, Grinstein, Grinstein, Guo, Ho, Hong, Jin-Li Guo, Lei Gao, Newman, Oliveira, Sun, Vázquez, Wang, White, Xue-Jiao Liu   +23 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Methyl group dynamics in a confined glass

, 2003
We present a neutron scattering investigation on methyl group dynamics in glassy toluene confined in mesoporous silicates of different pore sizes. The experimental results have been analysed in terms of a barrier distribution model, such a distribution ...
A. Alegría, A.J. Moreno, B. Frick, Bruneaux-Poulle, C. Alba-Simionesco, Colmenero, D. Morineau, G. Dosseh, Gutt, J. Colmenero, Kresge, Moreno, Morineau, Prager   +13 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Quantized chaotic dynamics and non-commutative KS entropy

, 1995
We study the quantization of two examples of classically chaotic dynamics, the Anosov dynamics of "cat maps" on a two dimensional torus, and the dynamics of baker's maps. Each of these dynamics is implemented as a discrete group of automorphisms of a von
Klimek, S., Lesniewski, A.
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

On calculating structural similarity metrics in population-based structural health monitoring

Data-Centric Engineering
The newly introduced discipline of Population-Based Structural Health Monitoring (PBSHM) has been developed in order to circumvent the issue of data scarcity in “classical” SHM.
Daniel S. Brennan, Timothy J. Rogers, Elizabeth J. Cross, Keith Worden   +3 more
doaj   +1 more source