Results 71 to 80 of about 671,076 (285)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Cup Coproducts in Hopf Cyclic Cohomology
, 2013 We define cup coproducts for Hopf cyclic cohomology of Hopf algebras and for its dual theory. We show that for universal enveloping algebras and group algebras our coproduct recovers the standard coproducts on Lie algebra homology and group homology ...
Hassanzadeh, Mohammad, Khalkhali, Masoud
core +1 more source
Veterinary Integrative SciencesA multiplex polymerase chain reaction (mPCR) assay was developed for the simultaneous detection of five bovine mastitis-associated pathogens including Staphylococcus simulans, Staphylococcus hominis, Staphylococcus aureus, Streptococcus ...
Pennapa Takam +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
A self-pairing theorem for tangle Floer homology
, 2016 We show that for a tangle $T$ with $-\partial^0T \cong \partial^1 T$ the Hochschild homology of the tangle Floer homology $\widetilde{\mathit{CT}}(T)$ is equivalent to the link Floer homology of the closure $T' = T/(-\partial^0T \sim \partial^1 T)$ of ...
Petkova, Ina, Vertesi, Vera
core +3 more sources
A limit approach to group homology
Journal of Algebra, 2008 In this paper, we consider for any free presentation $G = F/R$ of a group $G$ the coinvariance $H_{0}(G,R_{ab}^{\otimes n})$ of the $n$-th tensor power of the relation module $R_{ab}$ and show that the homology group $H_{2n}(G,{\mathbb Z})$ may be identified with the limit of the groups $H_{0}(G,R_{ab}^{\otimes n})$, where the limit is taken over the ...
Emmanouil, I., Mikhailov, R.
openaire +3 more sources
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Bioinformation analysis of rotavirus vaccine efficiency
Фармацевтичний журнал, 2019 A couple of studies have shown that viruses cause from 25 to 60% of acute intestinal infections (AII) cases, among which rotaviruses play a leading role in the structure of children's AII of viral etiology.
S. O. Soloviov +2 more
doaj +1 more source