Results 81 to 90 of about 671,076 (285)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
The Magnus representation and homology cobordism groups of homology cylinders
, 2015 A homology cylinder over a compact manifold is a homology cobordism between two copies of the manifold together with a boundary parametrization. We study abelian quotients of the homology cobordism group of homology cylinders. For homology cylinders over
Sakasai, Takuya
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International Journal of COPD, 2016 Mizuho Nishio,1 Kazuaki Nakane,2 Yutaka Tanaka3 1Clinical PET Center, Institute of Biomedical Research and Innovation, Hyogo, Japan; 2Department of Molecular Pathology, Osaka University Graduate School of Medicine and Health Science, Osaka, Japan ...
Nishio M, Nakane K, Tanaka Y
doaj
A group of segmented viruses contains genome segments sharing homology with multiple viral taxa
Journal of VirologyThe discovery of diverse segmented RNA viruses through metatranscriptomics has enabled researchers to trace their evolutionary trajectories. However, this effort has been hindered by the limited availability of complete genome sequences and the low ...
Huang Huang +12 more
doaj +1 more source
Проблемы особо опасных инфекций, 2013 Fully sequenced have been glycoprotein-G, sha-psi region, as well as H-end site of the L-gene in the rabies virus strain “Moscow 3253”. Compared are amino acid sequences of proteins of “Moscow 3253” strain and other fixed strains of the virus ...
I. V. Tuchkov +6 more
doaj +1 more source
Cyclic homology and group actions [PDF]
Journal of Geometry and Physics, 2018 v2: final version. To appear in J. Geom. Phys.
openaire +3 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The Lascar groups and the 1st homology groups in model theory
, 2017 Let $p$ be a strong type of an algebraically closed tuple over $B=\acl^{\eq}(B)$ in any theory $T$. Depending on a ternary relation $\indo^*$ satisfying some basic axioms (there is at least one such, namely the trivial independence in $T$), the first ...
Dobrowolski, Jan +2 more
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Algebraic Structures Based on a Classifying Space of a Compact Lie Group
Abstract and Applied Analysis, 2013 We analyze the algebraic structures based on a classifying space of a compact Lie group. We construct the connected graded free Lie algebra structure by considering the rationally nontrivial indecomposable and decomposable generators of homotopy groups ...
Dae-Woong Lee
doaj +1 more source