Results 161 to 170 of about 3,506,344 (312)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Checklist- and algorithm-based simulation training produce comparable improvements in teamwork-related shared mental models: a cluster-randomized study in trauma resuscitation teams. [PDF]

Eur J Trauma Emerg Surg
Beaugé Y, Kusch S, Thorsson L, Zentgraf M, Schauwienold J, Muenzberg M, Verboket R, Lefering R, Schweigkofler U, Faul P, Sterz J, Ruesseler M.   +11 more
europepmc   +1 more source

Experimental study of effectiveness of nonpoint source water pollution control group contract. [PDF]

The goal of this experimental study was to test an effectiveness of a group contract designed to control nonpoint source water pollution from farms' runoff (Pushkarskaya 2003).
Arkes, Hal, Bamba, Ibrahim, Pieratt, Jason, Pushkarskaya, Helen N.   +3 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Newly Graduated Nurses' Experiences of Taking Responsibility for Safe Nursing Care in Their First Year in Connection to COVID-19: A Qualitative Study. [PDF]

Nurs Open
Blomberg AC, Bisholt B.
europepmc   +1 more source

Group Education on CPAP–A Response [PDF]

Journal of Clinical Sleep Medicine, 2013
Christopher J, Lettieri, Robert J, Walter   +1 more
openaire   +2 more sources

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Psychometric validation of the responsibility scale and the mediating role of psychological distress in the association between personal responsibility and wellbeing in arab adults. [PDF]

BMC Psychol
Ali M, Alyousef DSA, Al-Dossary SA, Khasawneh MAS.   +3 more
europepmc   +1 more source