Results 61 to 70 of about 9,037,671 (282)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Study of the Activity and Possible Mechanism of Action of a Reversible Inhibitor of Recombinant Human KAT-2: A Promising Lead in Neurodegenerative and Cognitive Disorders

open access: yesMolecules, 2016
Abnormal levels of kynurenic acid (KYNA) in the human brain are believed to be connected to several central nervous system (CNS) diseases, therefore compounds which affect the production of this crucial metabolite are of interest in CNS drug development.
Alireza Nematollahi   +4 more
doaj   +1 more source

Group Theoretical Properties and Band Structure of the Lame Hamiltonian

open access: yes, 1999
We study the group theoretical properties of the Lame equation and its relation to su(1,1) and su(2). We compute the band structure, dispersion relation and transfer matrix and discuss the dynamical symmetry limits.Comment: 21 pages Revtex + 6 eps + 2 ...
  +25 more
core   +2 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

Work with groups in Family Health: concepts, structure and strategies for transcultural care. A qualitative study

open access: yesOnline Brazilian Journal of Nursing, 2007
This paper aims to investigate strategies of transcultural care emerging from group work in Family Health programs. It is a qualitative study based on Madeleine Leininger’s theory of the diversity and universality of care.
Maria Teresinha de Oliveira Fernandes   +1 more
doaj   +2 more sources

Generation of magnetic biohybrid microrobots based on MSC.sTRAIL for targeted stem cell delivery and treatment of cancer

open access: yesCancer Nanotechnology, 2023
Background Combining the power of magnetic guidance and the biological activities of stem cells transformed into biohybrid microrobots holds great promise for the treatment of several diseases including cancer.
Rebekah Anamarie Gundersen   +10 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

open access: yesFEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

On the Size and Structure of Group Cooperation [PDF]

open access: yes
This paper examines characteristics of cooperative behavior in a repeated, n-person, continuous action generalization of a Prisoner’s Dilemma game. When time preferences are heterogeneous and bounded away from one, how “much” cooperation can be achieved ...
Matthew Haag, Roger Lagunoff
core   +3 more sources

The probable direction of impact at Dhala impact structure, India deciphered from microfracture intensity and X-ray diffractometry: a new potential impact direction indicator

open access: yesEarth, Planets and Space
The most widely used method of determining impact direction employs asymmetric ejecta distribution around the crater. However, the active terrestrial landscape seldom preserves the pristine ejecta blanket, making it challenging for this analysis to be ...
Swastik Suman Behera   +4 more
doaj   +1 more source

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