Results 191 to 200 of about 1,341,685 (356)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Risk of second primary cancer among patients with early operable breast cancer registered or randomised in Danish Breast Cancer cooperative Group (DBCG) protocols of the 77, 82 and 89 programmes during 1977–2001 [PDF]

, 2008
Michael Andersson, Maj‐Britt Jensen, Gerda Engholm, Hans H. Storm   +3 more
openalex   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Embryonic Development and Growth Performance of the Tomato Hind Grouper (<i>Cephalopholis sonnerati</i>): A New Cultivated Aquaculture Species. [PDF]

Animals (Basel)
Wang Y, Ding T, Tian Y, Bai D, Jiao X, Wang S, Zhang C, Yang F, Wang L, Li Z, Li L, Xu Y, Liu Y.   +12 more
europepmc   +1 more source

Alterations in Whole-Body Insulin Sensitivity Resulting From Repeated Eccentric Exercise of a Single Muscle Group: A Pilot Investigation

, 2015
Javier T. Gonzalez, Martin J. Barwood, Stuart Goodall, Kevin Thomas, Glyn Howatson   +4 more
openalex   +2 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Comparative Analysis of Embryonic Development and Mitochondrial Genome of a New Intergeneric Hybrid Grouper (<i>Epinephelus fasciatus</i> ♀ × <i>Plectropomus leopardus</i> ♂). [PDF]

Animals (Basel)
Jiao X, Ding T, Tian Y, Guo Y, Wang Y, Wang S, Zhang C, Yang F, Wang L, Li Z, Li L, Xu Y, Liu Y.   +12 more
europepmc   +1 more source

Preliminary results of a protein electrophoretic analysis of genetic variation, population structure and gene flow in the Nassau grouper, Epinephelus striatus [PDF]

, 2005
Hateley, J.G.
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

C-CTX1 and 17-OH-C-CTX1 Accumulation in Muscle and Liver of Dusky Grouper (<i>Epinephelus marginatus</i>, Lowe 1834): A Unique Experimental Study Under Low-Level Exposure. [PDF]

Toxins (Basel)
Darias-Dágfeel Y, Sanchez-Henao A, Rambla-Alegre M, Diogène J, Flores C, Padilla D, Ramos-Sosa MJ, Poquet Blat PM, Silva Sergent F, Jerez S, Real F.   +10 more
europepmc   +1 more source