Results 221 to 230 of about 75,988 (312)

SGIV envelope protein VP088 facilitated virus replication via interacting with other viral proteins and promoting p62-dependent autophagic degradation of TBK1. [PDF]

J Virol
Yuan M, Zhang Y, Gao X, Wang W, Zhao Y, Qin Q, Huang X, Huang Y.   +7 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Characterization and antibody preparation of the gene products of grouper iridovirus ORF120L. [PDF]

Virus Res
Cheng CF, Chuang HC, Lai YS.
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Chromosome-level genome assembly of the hamour (orange-spotted grouper), <i>Epinephelus coioides</i>. [PDF]

F1000Res
Khalifa R, Bean T, Albatesh D, van Aerle R, Kahtir Z, Hizam Z, Gut M, Câmara F, Cruz F, Gómez-Garrido J, Alioto T, Santos E, Leitão A, Minardi D.   +13 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Polycyclic Aromatic Hydrocarbons (PAHs) and Phthalate Esters (PAEs) in the Farmed Fishes from Khanh Hoa, Viet Nam: Level and Health Risk Assessment. [PDF]

Foods
Nguyen XV, Hoang TD, Nguyen-Nhat NT, Nguyen QH, Nguyen XT, Nguyen TH, Truong SHT, Nguyen MT, Dao VH.   +8 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Methanotroph (<i>Methylococcus capsulatus</i>) bacteria meal, influences the intestinal microbiome, and improves intestinal barrier function and immunity in hybrid grouper (<i>Epinephelus fuscointestinetatus</i> ♀ × <i>E. lanceolatus</i> ♂). [PDF]

Anim Nutr
Zhang J, Liang W, Wang J, Longshaw M, Dong X, Yang Q, Liu H, Deng J, Tan B, Chi S.   +9 more
europepmc   +1 more source