Results 271 to 280 of about 152,389 (315)

Machine Learning‐Enhanced Optimization for High‐Throughput Precision in Cellular Droplet Bioprinting

Advanced Science, EarlyView.
A high‐throughput droplet‐based cellular bioprinting platform enhanced with machine learning optimizes five key printing parameters—bioink viscosity, nozzle size, printing time, printing pressure, and cell concentration—to enable accurate prediction of droplet size.
Jaemyung Shin, Ryan Kang, Kinam Hyun, Zhangkang Li, Hitendra Kumar, Kangsoo Kim, Simon S. Park, Keekyoung Kim   +7 more
wiley   +1 more source

Molecular basis of the functions of the mammalian neuronal growth cone revealed using new methods. [PDF]

Proc Jpn Acad Ser B Phys Biol Sci, 2019
Igarashi M.
europepmc   +1 more source

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Advanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang   +5 more
wiley   +1 more source

Cubic Phase‐Inducible Zwitterionic Phospholipids Improve the Functional Delivery of mRNA

Advanced Science, EarlyView.
In this study, a chemically engineered zwitterionic phospholipids derived from 1,2‐dioleoyl‐3‐sn‐glycero‐phosphoethanolamine (DOPE), DOPE‐Cx, are designed. The DOPE‐Cx lipids induce a cubic phase upon mixing with phosphatidylcholine, facilitate membrane fusion‐mediated endosomal escape, and enhance the functional delivery of mRNA.
Kazuki Iwakawa, Rikako Sato, Mariko Konaka, Yuma Yamada, Hideyoshi Harashima, Yusuke Sato   +5 more
wiley   +1 more source

Self‐Catalyzed Chemically Coalescing Liquid Metal Emulsions

Advanced Science, EarlyView.
A new type of liquid metal emulsion is developed that chemically activates and becomes electrically conductive under mild thermal stimulus. The activation mechanism occurs through a unique set of catalytic dehalogenation and chemical oxide etching reactions. These emulsions are 3D printable and exhibit high shape retention after being heated.
Stephanie F. Zopf, Ramón E. Sánchez Cruz, Chloe Kekedjian, Lu Ping, Javier M. Morales Ferrer, Jean Paul Soto Aquino, Rongxuan Xie, Xi Ling, J. William Boley   +8 more
wiley   +1 more source

A Compound Screen Based on Isogenic hESC‐Derived β Cell Reveals an Inhibitor Targeting ZnT8‐Mediated Zinc Transportation to Protect Pancreatic β Cell from Stress‐Induced Cell Death

Advanced Science, EarlyView.
Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. The study demonstrates that WFS1–ZnT8–zinc axis regulates vicious cycle of zinc transportation and cellular stress in pancreatic β cell. Based on that, the study applies a strategy for compound screening targeting ZnT8 based on human models, and identifies anisomycin, as a ...
Rui Hu, Qing Ma, Yunhui Kong, Zhaoyue Wang, Minglu Xu, Xiangyi Chen, Yajuan Su, Tinghui Xiao, Qing He, Xuan Wang, Wenjun Xu, Yiling Yang, Xushu Wang, Xiaobo Li, Yanfang Liu, Shuangshuang Chen, Rui Zhao, Meng Guo, Gaowei Wang, Weida Li   +19 more
wiley   +1 more source

Microfluidics‐Based Microcarriers for Live‐Cell Delivery

Advanced Science, EarlyView.
In this review, recent advancements in microfluidics‐based microcarriers for live‐cell delivery are highlighted. The structural designs of microfluidic‐derived cell‐laden microcarriers are systematically categorized, emphasizing innovative approaches in the fabrication of microspheres, microfibers, and microneedles.
Zhonglin Fang, Xinyuan Yang, Chong Wang, Luoran Shang   +3 more
wiley   +1 more source

Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration

Advanced Science, EarlyView.
The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan, Meiqian Wu, Chaonan Zhu, Hao Yu, Minh Duc Pham, Katharina Bottermann, Yijie Mao, Yue Wang, Mathias Langner, Mirko Peitzsch, Arka Provo Das, Silke Kauferstein, Jonathan Ward, Peter Mirtschink, Andreas Michael Zeiher, Stefanie Dimmeler, Jaya Krishnan   +16 more
wiley   +1 more source

High‐Speed 3D Printing Coupled with Machine Learning to Accelerate Alloy Development for Additive Manufacturing

Advanced Science, EarlyView.
This work shows combining high‐throughput experiments of metal 3D printing with data science‐driven prediction leads to faster alloy development. Researchers develop steel alloy specimens specifically for 3D printing by adjusting aluminum content (0–10 wt.%) and energy input during printing.
Avinash Hariharan, Marc Ackermann, Stephan Koss, Ali Khosravani, Johannes Henrich Schleifenbaum, Patrick Köhnen, Surya R. Kalidindi, Christian Haase   +7 more
wiley   +1 more source

Silicon Carbide Photonic Crystal Photoelectrode

Advanced Science, EarlyView.
A 3C‐SiC photoelectrode with a slanted parabolic pore photonic crystal architecture enhances photogeneration for efficient photoelectrochemical water splitting through the remarkable light‐trapping capabilities of photonic crystal slow‐light modes.
Xiwen Zhang, Sajeev John
wiley   +1 more source