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Growth Cone Collapse Assay [PDF]
, 2014 The growth cone collapse assay has proved invaluable in detecting and purifying axonal repellents. Glycoproteins/proteins present in detergent extracts of biological tissues are incorporated into liposomes, added to growth cones in culture and changes in morphology are then assessed.
Roger J. Keynes +2 more
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Vesicular movements in the growth cone
Neurochemistry International, 2018Growth cones, which are the highly motile tips of extending neuronal processes in developing neurons, have many vesicles. These vesicles are likely essential for the membrane expansion that is required for nerve growth, and probably coordinate with rearrangement of the cytoskeletons.
Motohiro Nozumi, Michihiro Igarashi
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2013
Growth cone collapse is an easy and efficient test for detecting and characterizing axon guidance activities secreted or expressed by cells. It can also be used to dissect signaling pathways by axon growth inhibitors and to isolate therapeutic compounds that promote axon regeneration.
Alexander I. Son, Xin Yue, Renping Zhou
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Growth cone collapse is an easy and efficient test for detecting and characterizing axon guidance activities secreted or expressed by cells. It can also be used to dissect signaling pathways by axon growth inhibitors and to isolate therapeutic compounds that promote axon regeneration.
Alexander I. Son, Xin Yue, Renping Zhou
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Microtubule organization in growth cones
Biochemical Society Transactions, 1991Neuronal growth cones guide growing axons and dendrites (neurites) through developing embryos by detecting extrinsic guidance cues and transducing the signal into changes in motile behavior. In this chapter, the role of the growth cone cytoskeleton in these events, in particular the microtubules, is discussed.
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Microtubules and growth cone function
Journal of Neurobiology, 2003AbstractIt has been recognized for a long time that the neuronal cytoskeleton plays an important part in neurite growth and growth cone pathfinding, the mechanism by which growing axons find an appropriate route through the developing embryo to their target cells.
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Growth cone responses to growth and chemotropic factors
European Journal of Neuroscience, 2008AbstractDuring nervous system development axons reach their target areas under the influence of numerous guidance cues that affect rate and direction of growth. This report addresses the unsettled question of whether and to what extent growth velocity and turning responses (attraction, repulsion) are interdependent.
Jesse C. Gatlin +3 more
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Neuronal growth cone migration
Experientia, 1990The neuronal growth cone is a semi-autonomous portion of the developing neuron that is highly specialized for motile activity. Migrating neurons may share some features with neuronal growth cones. I review some of what has been learned about growth cone initiation, the differentiation of axons and dendrites, the role of the cytoskeleton in motility ...
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Growth cone calcium elevation by GABA
The Journal of Comparative Neurology, 1996Cytoplasmic calcium plays a key role in neurite growth. In contrast to previous work suggesting that gamma aminobutyrate's (GABA) role in regulating growth cone calcium is primarily to antagonize the effects of glutamate, we report that GABA can act in an excitatory manner on developing hypothalamic neurites, independently raising calcium in growing ...
AN van den Pol, K Obrietan
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The Synapse and the Growth Cone
1991Abstract Although anatomists by the r 8gos could agree that nerve cells are separate units and interact by contacts, it left many unanswered questions. Two questions in particular aroused great interest. One was the nature of the contacts between neurons made by axons and dendrites.
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Can there be growth without growth cones?
Seminars in Neuroscience, 1996Abstract In-vivo imaging of the development of complex retinotectal axon arbors indicates that arbors branches can form and extend in the absence of growth cones. A variety of imaging protocols were used to observe arbor elaboration over a range of time intervals and total observation periods.
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