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Pathfinding by the Growth Cone
1996The growth cone is a specialization of developing and regenerating neurons which samples the environment and is attracted or repelled by the cues it detects. Different growth cones express different surface receptors or exhibit different second messenger responses to a given cue.
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cell and growth cone migrations
Cold Spring Harbor Monograph Archive, 1997I. INTRODUCTION During morphogenesis, some cells migrate from their origins to distant locations. The complex, stereotyped migrations of axonal growth cones, for example, determine the connectivity of the nervous system. Motile cells and processes can undergo directed movements in response to spatially patterned molecules (Keynes and Cook 1995; Garrity
Antebi, A. +3 more
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Calcium signalling in growth cone migration
Cell Calcium, 2005Growth cones, the motile structures at the tips of advancing axons and dendrites, respond to a wide range of cues by either turning towards or away from the cue. Cytosolic calcium signals appear to mediate a large fraction of both types of response.
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From the Growth Cone to the Synapse
1976The development of specific neuronal connections must be based on a set of intricate control mechanisms. The complexity of this fascinating problem results from (1) the enormous number of elements involved (in the human CNS, an estimated 1014 synapses are formed), (2) the long pathway of certain nerve fibers, and (3) the high selectivity of their ...
Rosemary Rees, Karl H. Pfenninger
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Science Signaling, 2009
The tumor suppressor p53 may regulate Rho kinase to contribute to axonal growth cone motility.
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The tumor suppressor p53 may regulate Rho kinase to contribute to axonal growth cone motility.
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