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Sites of plasmalemmal expansion in growth cones
Developmental Brain Research, 1993Studies on plasmalemmal expansion in isolated nerve growth cones identified large, clear vesicles characteristically found in growth cones as the plasmalemmal precursor. The present article examines these plasmalemmal precursor vesicles (PPVs) in greater detail in the intact cell.
K H, Pfenninger, L B, Friedman
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Rapid effects of laminin on the growth cone
Neuron, 1992To gain insight into how laminin promotes neurite growth, high resolution video microscopy was used to determine the rapid effects of laminin on growth cone structure. Sympathetic growth cones in serum-free medium on polylysine substrate displayed extensive motility and protrusive activity and often had large lamellipodia.
R J, Rivas +2 more
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Autonomous regulation of growth cone filopodia
Journal of Neurobiology, 1998The fan-shaped array of filopodia is the first site of contact of a neuronal growth cone with molecules encountered during neuronal pathfinding. Filopodia are highly dynamic structures, and the "action radius" of a growth cone is strongly determined by the length and number of its filopodia.
V, Rehder, S, Cheng
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Science's STKE, 2004
The semaphorin family of guidance cues act predominantly through plexin receptors at the surface of various cell types. The small guanosine triphosphatases (GTPases) Rho and Rac have been implicated as downstream effectors of semaphorin-plexin interactions that modulate the cytoskeleton, but details of how plexins activate these GTPases ...
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The semaphorin family of guidance cues act predominantly through plexin receptors at the surface of various cell types. The small guanosine triphosphatases (GTPases) Rho and Rac have been implicated as downstream effectors of semaphorin-plexin interactions that modulate the cytoskeleton, but details of how plexins activate these GTPases ...
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Can there be growth without growth cones?
Seminars in Neuroscience, 1996Abstract In-vivo imaging of the development of complex retinotectal axon arbors indicates that arbors branches can form and extend in the absence of growth cones. A variety of imaging protocols were used to observe arbor elaboration over a range of time intervals and total observation periods.
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Calcium signalling in growth cone migration
Cell Calcium, 2005Growth cones, the motile structures at the tips of advancing axons and dendrites, respond to a wide range of cues by either turning towards or away from the cue. Cytosolic calcium signals appear to mediate a large fraction of both types of response.
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The Synapse and the Growth Cone
1991Abstract Although anatomists by the r 8gos could agree that nerve cells are separate units and interact by contacts, it left many unanswered questions. Two questions in particular aroused great interest. One was the nature of the contacts between neurons made by axons and dendrites.
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Pathfinding by the Growth Cone
1996The growth cone is a specialization of developing and regenerating neurons which samples the environment and is attracted or repelled by the cues it detects. Different growth cones express different surface receptors or exhibit different second messenger responses to a given cue.
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2000
'I had the good fortune to behold for the first time that fantastic ending of the growing axon. In my sections of the spinal cord of the three day chick embryo, this ending appeared as a concentration of protoplasm of conical form, endowed with amoeboid movements.
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'I had the good fortune to behold for the first time that fantastic ending of the growing axon. In my sections of the spinal cord of the three day chick embryo, this ending appeared as a concentration of protoplasm of conical form, endowed with amoeboid movements.
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