Results 121 to 130 of about 10,322,817 (363)
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
Growth Disorders in Children and Adolescents. [PDF]
, 1964 Benjamin M. Kagan
openalex +2 more sources
Journal of the Formosan Medical Association, 2017 Few studies have evaluated craniofacial growth in boys and girls with idiopathic short stature (ISS) during growth hormone (GH) treatment. The aim of this study was to evaluate the effect of GH treatment on craniofacial growth in children with ISS ...
Sung-Hwan Choi +4 more
doaj +1 more source
Novel and unscrutinized immune entities of the zebrafish gut
FEBS Letters, EarlyView.Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil +5 more
wiley +1 more source
Endocrine Connections, 2018 Growth hormone (GH) is used to treat short stature and growth failure associated with growth disorders. Birth size and GH status variably modulate response to GH therapy.
Robert Rapaport +5 more
doaj +1 more source
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
Unveiling the dynamics of stunting: a qualitative exploration of parenting patterns and toddlers aged 6–59 months in Bejiharjo, Indonesia [PDF]
Child Health Nursing ResearchPurpose This research was conducted to explore the experience of mothers in raising stunted toddlers aged between 6–59 months. It also examined the perceptions of parenting styles shaped by socio-cultural contexts and time constraints affecting the ...
Intan Azzahra +2 more
doaj +1 more source
Modelling postharvest quality behaviour as affected by preharvest conditions [PDF]
, 2003 Some hundred years ago, wise men decided that preharvest research and applications had to be regarded separated from the postharvest handling and behaviour. Over the years, both areas developed completely separated.
Heuvelink, E. +3 more
core +2 more sources
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders
Annals of Neurology, 2015 The diagnosis of mitochondrial disorders (MDs) is occasionally difficult because patients often present with solitary, or a combination of, symptoms caused by each organ insufficiency, which may be the result of respiratory chain enzyme deficiency ...
S. Yatsuga +10 more
semanticscholar +1 more source