Results 181 to 190 of about 894,625 (303)

Growth hormone and ageing

, 2000
The proportion of elderly people is steadily growing in Western societies. The result is a disproportionate accumulation of the oldest and most vulnerable sector of the population, suffering from frailty-associated disorders and cardiovascular diseases ...
Bengtsson, B A, Svensson, J, Johannsson, Gudmundur,   +2 more
core  

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Zebrafish gon4la mutants recapitulate human GON4L-related growth disorders and reveal novel metabolic organs abnormalities. [PDF]

Sci Rep
Tsai SM, Hsu CH, Chiang IC, Liao WN, Chen JK, Jiang YJ.   +5 more
europepmc   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Indirect exposure to organophosphate pesticides and its possible growth disorders in children of farmers in Northwest Mexico. [PDF]

Int Arch Occup Environ Health
Ochoa-Ruiz E, Moreno-García AI, Licea-Espinoza DA, Pineda-García G, Carranza-Ambriz KP, Soto-Rodriguez KK, García-Ledezma A, Cornejo-Bravo JM, Martínez AL, Mondani E, Serrano-Medina A.   +10 more
europepmc   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Construction and evaluation of a height prediction model for children with growth disorders treated with recombinant human growth hormone. [PDF]

BMC Endocr Disord
Zhu F, Wu A, Chen L, Xia Y, Luo X, Zhu J, Huang L, Zhang Y.   +7 more
europepmc   +1 more source

Managing Paediatric Growth Disorders: Integrating Technology Into a Personalised Approach [PDF]

J Clin Res Pediatr Endocrinol, 2020
Child J, Davies C, Frost K, McDermid E, Pidcock R, Weinman J, Savage MO.   +6 more
europepmc   +1 more source

Efficacy of Intermittent Theta‐Burst Stimulation for Prolonged Disorders of Consciousness: A Prospective, Randomized, Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Emerging evidence suggests that low‐frequency neural oscillations are dynamically regulated by consciousness levels, with the recovery of low cortical activity potentially serving as a neurophysiological substrate for conscious emergence. Targeted enhancement of these low‐frequency rhythms in patients with disorders of consciousness
Chuan Xu, Jun Hu, Qianqian Wu, Min Wu, Yamei Yu, Hangcheng Li, Jian Gao, Jingqi Li, Nai Ding, Jie Yu, Benyan Luo   +10 more
wiley   +1 more source

The influence of multivitamins on neurological and growth disorders: a cross-sectional study. [PDF]

Front Nutr
Zhu J, Xu P, Yan W, Hu Y, Guo H, Chen F, Bigambo FM, Wang X.   +7 more
europepmc   +1 more source