Results 161 to 170 of about 894,625 (303)

Human growth disorders associated with impaired GH action: Defects in STAT5B and JAK2. [PDF]

Mol Cell Endocrinol, 2021
Hwa V.
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Integrated Clinical and Molecular Profiling of Fetal Growth Disorders in the First Trimester. [PDF]

Int J Mol Sci
Starodubtseva N, Tokareva A, Frankevich N, Kononikhin A, Bugrova A, Indeykina M, Kukaev E, Derenko A, Frankevich V, Nikolaev E, Sukhikh G.   +10 more
europepmc   +1 more source

Psychotic Disorders and Posttraumatic Growth

Posttraumatic growth (PTG) represents the phenomenon of positive changes that a person can experience after a traumatic experience. Traditionally associated with traumatic events such as loss or injury, PTG is increasingly being investigated in people ...
Damašek, Igor, Delalle, Mirela, Pavličević Tomas, Ivana, Čavajda, Zoran, Erić, Ivan, Petek Erić, Anamarija   +5 more
core  

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Effectiveness and Safety of Hormonal Treatments in Children with Growth Disorders: A Systematic Review of Clinical Evidence. [PDF]

Clin Pract
Martín Pérez IM, Martín Pérez SE.
europepmc   +1 more source

Decomposition of socioeconomic inequality in growth disorders to its determinants in pediatric population: the CASPIAN IV study. [PDF]

J Diabetes Metab Disord, 2021
Djalalinia S, Kelishadi R, Qorbani M, Sheidaei A, Emamian MH, Motlagh ME, Ardalan G, Asayesh H, Mahdavi Gorabi A, Heshmat R.   +9 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Application of artificial intelligence in diagnosis and management of fetal growth disorders: a comprehensive review. [PDF]

Front Med (Lausanne)
Ługowski F, Babińska J, Stanirowski PJ.   +2 more
europepmc   +1 more source