Results 261 to 270 of about 7,031,181 (311)
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British Medical Bulletin, 1989
The existence of fibroblast growth factors (FGFs) was proposed over 40 years ago to account for the ability of tissue extracts to stimulate fibroblast proliferation. In the 1970s it became clear that preparations containing FGF activity were in fact pleiotropic, affecting the growth and function of a wide variety of mesenchymal, endocrine and neural ...
A, Baird, P A, Walicke
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The existence of fibroblast growth factors (FGFs) was proposed over 40 years ago to account for the ability of tissue extracts to stimulate fibroblast proliferation. In the 1970s it became clear that preparations containing FGF activity were in fact pleiotropic, affecting the growth and function of a wide variety of mesenchymal, endocrine and neural ...
A, Baird, P A, Walicke
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Progress in Growth Factor Research, 1991
The role of polypeptide growth factors in cardiovascular ontogeny, function, and pathologic states is poorly understood. Recent investigations demonstrate that the myocardium produces both known and novel growth factors, which are highly regulated during development and disease, and have suggested that peptide growth factors may direct cardiac ...
M D, Schneider, T G, Parker
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The role of polypeptide growth factors in cardiovascular ontogeny, function, and pathologic states is poorly understood. Recent investigations demonstrate that the myocardium produces both known and novel growth factors, which are highly regulated during development and disease, and have suggested that peptide growth factors may direct cardiac ...
M D, Schneider, T G, Parker
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Current Opinion in Cell Biology, 1991
The role of growth factors in development is under analysis on three main fronts: examination of patterns of growth factor expression in embryogenesis, studies of biological activity in vitro, and mutational analysis in vivo. Recent findings indicate that growth factors control developmental decisions, are strictly controlled in their delivery to ...
J K, Heath, V, Valancius-Mangel
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The role of growth factors in development is under analysis on three main fronts: examination of patterns of growth factor expression in embryogenesis, studies of biological activity in vitro, and mutational analysis in vivo. Recent findings indicate that growth factors control developmental decisions, are strictly controlled in their delivery to ...
J K, Heath, V, Valancius-Mangel
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British Medical Bulletin, 1989
The growth and development of mature blood cells in vitro is supported by a series of glycoproteins with a range of biological activities. Many of these growth factors have been molecularly cloned, purified to homogeneity, and their biological effects determined on various target cells.
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The growth and development of mature blood cells in vitro is supported by a series of glycoproteins with a range of biological activities. Many of these growth factors have been molecularly cloned, purified to homogeneity, and their biological effects determined on various target cells.
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1977
Publisher Summary Nerve growth factor (NGF) is one of an increasing number of growth factors that has been recognized as being essential for the survival and maintenance of specific types of cells. This chapter discusses the nerve growth factor from mouse submaxillary gland, the high molecular weight form of NGF (7 S NGF), the biosynthesis of NGF ...
A C, Server, E M, Shooter
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Publisher Summary Nerve growth factor (NGF) is one of an increasing number of growth factors that has been recognized as being essential for the survival and maintenance of specific types of cells. This chapter discusses the nerve growth factor from mouse submaxillary gland, the high molecular weight form of NGF (7 S NGF), the biosynthesis of NGF ...
A C, Server, E M, Shooter
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Growth Factors and Growth Factor Inhibitors
1997This chapter will outline novel treatment strategies predicated on the modulation of growth factor or cytokine-mediated signal transduction pathways. Several excellent recent monographs have addressed this tissue from the point of view of inhibitors of individual pathway constituents (1,2).The current focus will be on defining the pathways potentially ...
Edward A. Sausville, Dan L. Longo
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The International journal of developmental biology, 1999
Signalling between cells in the developing vertebrate embryo is essential for normal embryonic development. In the mid 1970's, signal transduction research started at the Hubrecht Laboratory with special emphasis on analysis of the signalling mechanisms that direct cell proliferation and differentiation.
de Laat, S.W. +7 more
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Signalling between cells in the developing vertebrate embryo is essential for normal embryonic development. In the mid 1970's, signal transduction research started at the Hubrecht Laboratory with special emphasis on analysis of the signalling mechanisms that direct cell proliferation and differentiation.
de Laat, S.W. +7 more
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Growth factors and growth factor receptors.
British journal of hospital medicine, 1993Peptide growth factors and their cell surface-associated receptors are important determinants of normal and pathological growth reactions. Through signal transduction pathways, receptor occupancy triggers the production of intracellular downstream effector molecules which ultimately cause cell proliferation.
M R, Alison, N A, Wright
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Cell Biology International, 1995
ABSTRACTKeratinocyte growth factor (KGF) is a member of the heparin‐binding fibroblast growth factor family (FGF‐7) with a distinctive pattern of target‐cell specificity. Studies performed in cell culture suggested that KGF was mitogenically active only on epithelial cells, albeit from a variety of tissues. In contrast, KGF was produced solely by cells
Jeffrey S. Rubin +10 more
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ABSTRACTKeratinocyte growth factor (KGF) is a member of the heparin‐binding fibroblast growth factor family (FGF‐7) with a distinctive pattern of target‐cell specificity. Studies performed in cell culture suggested that KGF was mitogenically active only on epithelial cells, albeit from a variety of tissues. In contrast, KGF was produced solely by cells
Jeffrey S. Rubin +10 more
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Clinical Orthopaedics and Related Research, 1991
Bone volume is determined by the relative rates of bone formation and bone resorption. Recent research in several laboratories suggests that growth factors may act locally to modulate bone formation by stimulating osteoblast proliferation and activity.
S, Mohan, D J, Baylink
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Bone volume is determined by the relative rates of bone formation and bone resorption. Recent research in several laboratories suggests that growth factors may act locally to modulate bone formation by stimulating osteoblast proliferation and activity.
S, Mohan, D J, Baylink
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