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Platelet-Derived Growth Factor
Definitions, 2020A family of growth factors that act as potent mitogens and are involved in the stimulation of angiogenesis. There are four members of this family (platelet-derived growth factor A, B, C and D) that are characterized by a core motif of eight cysteines ...
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Vascular endothelial growth factor is a secreted angiogenic mitogen.
Science, 1989Vascular endothelial growth factor (VEGF) was purified from media conditioned by bovine pituitary folliculostellate cells (FC). VEGF is a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis in vivo ...
D. Leung +4 more
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Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis.
Journal of Clinical Oncology, 2005New blood vessel formation (angiogenesis) is a fundamental event in the process of tumor growth and metastatic dissemination. Hence, the molecular basis of tumor angiogenesis has been of keen interest in the field of cancer research.
D. Hicklin, L. Ellis
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Mechanism of action and in vivo role of platelet-derived growth factor.
Physiological Reviews, 1999Platelet-derived growth factor (PDGF) is a major mitogen for connective tissue cells and certain other cell types. It is a dimeric molecule consisting of disulfide-bonded, structurally similar A- and B-polypeptide chains, which combine to homo- and ...
C. Heldin, B. Westermark
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Transforming growth factor-beta regulation of immune responses.
Annual Review of Immunology, 2006Transforming growth factor-beta (TGF-beta) is a potent regulatory cytokine with diverse effects on hemopoietic cells. The pivotal function of TGF-beta in the immune system is to maintain tolerance via the regulation of lymphocyte proliferation ...
Ming O. Li +4 more
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The nerve growth factor 35 years later.
Science, 1987"Embryogenesis is in some way a model system. It has always been distinguished by the exactitude even punctitio, of its anatomical descriptions. An experiment by one of the great masters of embryology could be made the text of a discourse on scientific ...
R. Levi‐montalcini
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Nerve Growth Factor and Pain Mechanisms.
Annual Review of Neuroscience, 2017Nerve growth factor (NGF) antagonism is on the verge of becoming a powerful analgesic treatment for numerous conditions, including osteoarthritis and lower back pain. This review summarizes the historical research, both fundamental and clinical, that led
Franziska Denk, D. Bennett, S. McMahon
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Transforming Growth Factor β in Tissue Fibrosis
, 1994Progressive fibrosis in the kidney, liver, lung, heart, bone marrow, and skin is both a major cause of suffering and death and an important contributor to the cost of health care.
W. A. Border, N. Noble
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Role of transforming growth factor beta in human disease.
New England Journal of Medicine, 2000In human tissues, normal homeostasis requires intricately balanced interactions between cells and the network of secreted proteins known as the extracellular matrix.
G. Blobe, W. Schiemann, H. Lodish
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Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product.
Science, 1991Hepatocyte growth factor (HGF) is a plasminogen-like protein thought to be a humoral mediator of liver regeneration. A 145-kilodalton tyrosyl phosphoprotein observed in rapid response to HGF treatment of intact target cells was identified by immunoblot ...
D. Bottaro +6 more
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