Results 81 to 90 of about 7,031,181 (311)

The novel GLP‐1/GIP analogue DA5‐CH reduces tau phosphorylation and normalizes theta rhythm in the icv. STZ rat model of AD

Brain and Behavior, 2020
Introduction Alzheimer's disease (AD) is the most common progressive neurodegenerative disease for which there is no cure. Recent studies have shown a close link between type 2 diabetes and AD, which suggested that drugs for type 2 diabetes may be ...
Cheng Li, Weizhen Liu, Xiaohui Li, Zijuan Zhang, Huaxin Qi, Shijin Liu, Ningning Yan, Ying Xing, Christian Hölscher, Zhiju Wang   +9 more
doaj   +1 more source

Growth with a Fixed Factor [PDF]

Consider an economy in which a fi…xed supply of unskilled labor can be combined with knowledge capital to produce consumption. The technology for accumulating knowledge capital is linear in knowledge capital.
Erzo G. J. Luttmer
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Population growth, factor accumulation, and productivity [PDF]

In research on how population growth affects economic performance, some researchers stress that population growth reduces the natural resources and capital (physical and human) per worker while other researchers stress how greater population size and ...
Pritchett, Lant
core  

Control of human endometrial stromal cell motility by PDGF-BB, HB-EGF and trophoblast-secreted factors [PDF]

, 2013
Human implantation involves extensive tissue remodeling at the fetal-maternal interface. It is becoming increasingly evident that not only trophoblast, but also decidualizing endometrial stromal cells are inherently motile and invasive, and likely ...
A Brar, A Samalecos, A Stavreus-Evers, AA Brahmbhatt, Ana-Maria Bamberger, Anja Wolf, Annemarie Samalecos, AT Fazleabas, B Cloke, B Gellersen, B Gellersen, BA Lessey, Birgit Gellersen, C Ferretti, C Fischer, C Gaggioli, Charlotte H. E. Weimar, CHE Weimar, CM Boomsma, CP Thomas, D Gentilini, D Gentilini, D Haouzi, DE Clark, EE Sander, ER Norwitz, F Chang, F Llorens, F Lyall, G Gaus, G Teklenburg, G Teklenburg, GE Lash, GE Lash, GJ Burton, H Funayama, H Matsumoto, H Xie, HJ Lim, HJ Yoo, I Ihnatovych, IY Yotova, J Anacker, J Baulida, J Fiedler, JJ Brosens, JJ Brosens, JW Tullai, JX Zhu, K Chobotova, K Kawada, K Red-Horse, K Roepstorff, LA Salamonsen, M Bilban, M Bilban, M Cohen, M Gonzalez, M Knöfler, M Knöfler, M Salker, Maren Schwenke, Martin Knöfler, Meijing Wang, Michelle Kruse, MW Maijenburg, Nick S. Macklon, NJ Hannan, NJ Hannan, P Burke, P Jessmon, P Jessmon, P Kaufmann, Philipp Velicky, R Apps, RE Leach, RE Leach, RE Leach, RJ Petrie, RL Kendall, RN Popovici, S Grewal, S Grewal, SK Mitra, Y Jiang, Y Yamazaki   +85 more
core   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Assessing the potential for knowledge-based development in transition countries. Bruegel Working Paper 2010/01, May 2010 [PDF]

, 2010
This Working Paper by Bruegel Senior Fellow Reinhilde Veugelers examines the potential for a knowledge-based growth path in transition countries of central and eastern Europe, the Caucasus and Central Asia.
Veugelers, Reinhilde.
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Globalization, Factor Endowments and Scale-Invariant Growth [PDF]

The paper develops a two-country dynamic general-equilibrium model of growth without scale effects to explore the effects of globalization on long-run growth and wages. Higher quality products are endogenously discovered through stochastic and sequential
Constantinos Syropoulos, Elias Dinopoulos   +1 more
core   +3 more sources