Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Control of invasive growth by hepatocyte growth factor (HGF) and related scatter factors
, 1997 Hepatocyte growth factor (HGF) is the prototype of a family of structurally related soluble molecules, named scatter factors (SFs). These control a complex genetic programme leading to cell-dissociation, migration in the extracellular matrix, growth ...
Tamagnone, Luca
core +1 more source
Gene expression patterns of insulin-like growth factor 1, insulin-like growth factor 2 and insulin-like growth factor binding protein 3 in human placenta from pregnancies with intrauterine growth restriction [PDF]
, 2011 Introduction: In this study, we compared insulin-like growth factor (IGF)-gene expression patterns and characteristics of glucose and insulin metabolism in human placenta from pregnancies with or without intrauterine growth restriction (IUGR).
Tóth, Katalin +23 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Sources of India's economic growth: trends in total factor productivity [PDF]
Indian Economy, Total Factor Productivity, and Economic ...
Arvind Virmani
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Structure Determination of Vascular Endothelial Growth Factor Heparin-Binding Domain in Complex with a Dna Aptamer [PDF]
, 2017 Vascular endothelial growth factor is a cytokine that is required for the maintenance of healthy vasculature, and it is responsible for a variety of pathogenic conditions, such as age-related macular degeneration and tumor growth in numerous cancers.
Hunt, Sabrina Robin
core +2 more sources
Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2007 Salt stress as a major adverse factor can lower leaf water potential, leading to reduced turgor and some other responses, and ultimately lower crop productivity in arid and semi arid zones.
Ezatollah ESFANDIARI +3 more
doaj +1 more source
Growth factor regulation of growth factor production by multiple gene transfer to chondrocytes
, 2013 Of the many classes of molecules regulated by growth factors, growth factors themselves are not well investigated. We tested the hypothesis that combinations of endogenous growth factors interactively regulate the production of other growth factors ...
Trippel, Stephen B. +3 more
core +1 more source
Recent Estimates of the Structure of the Factor VIIa (FVIIa)/Tissue Factor (TF) and Factor Xa (FXa) Ternary Complex [PDF]
, 2010 The putative structure of the Tissue Factor/Factor VIIa/Factor Xa (TF/FVIIa/FXa) ternary complex is reconsidered. Two independently derived docking models proposed in 2003 (one for our laboratory: CHeA and one from the Scripps laboratory: Ss) are ...
Chandrasekaran, Vasu +4 more
core +1 more source