Results 61 to 70 of about 16,701,675 (216)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The Russian Military-Industrial Complex as a Factor of National Security and Sustainable Socio-Economic Development

Экономика и управление, 2019
This study examines the role of the militaryindustrial complex (MIC) in creating opportunities for sustainable socio-economic development and national security of the Russian Federation. Tasks.
Vladimir A. Plotnikov, Andrey V. Kharlamov   +1 more
doaj  

Inhibition of the Staphylococcus aureus c-di-AMP cyclase DacA by direct interaction with the phosphoglucosamine mutase GlmM.

PLoS Pathogens, 2019
c-di-AMP is an important second messenger molecule that plays a pivotal role in regulating fundamental cellular processes, including osmotic and cell wall homeostasis in many Gram-positive organisms.
Tommaso Tosi, Fumiya Hoshiga, Charlotte Millership, Rahul Singh, Charles Eldrid, Delphine Patin, Dominique Mengin-Lecreulx, Konstantinos Thalassinos, Paul Freemont, Angelika Gründling   +9 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Mussel-Inspired Tissue-Adhesive Hydrogel Based on the Polydopamine–Chondroitin Sulfate Complex for Growth-Factor-Free Cartilage Regeneration

, 2018
Glycosaminoglycan-based hydrogels are widely used for cartilage repair because glycosaminoglycans are the main component of the cartilage extracellular matrix and can maintain chondrocyte functions.
Chun Wai Chan (5621057), Xiong Lu (115616), Jielong Xu (1418485), Menghao Wang (5593907), Lu Han (151620), Huipin Yuan (2740951), Hongping Zhang (152549), Donglin Gan (5621054), Kefeng Wang (1418479), Liwei Yan (5593904), Pengfei Li (290581), Liming Fang (2740945)   +11 more
core   +1 more source

Topoisomerase IIα promotes activation of RNA polymerase I transcription by facilitating pre-initiation complex formation [PDF]

, 2013
Type II DNA topoisomerases catalyse DNA double-strand cleavage, passage and re-ligation to effect topological changes. There is considerable interest in elucidating topoisomerase II roles, particularly as these proteins are targets for anti-cancer drugs.
Porter, Andrew C. G., Panov, Konstantin I; id_orcid, Zomerdijk, Joost C.B.M., Russell, J., Miller, G. (Gail), Zomerdijk, Joost C B M, Porter, A.C., Porter, Andrew C G, Volkov, A., Panov, K.I., Panov, Konstantin I., Russell, J. (Jackie), Panova, T., Zomerdijk, J.C., Miller, Gail, Porter, Andrew C.G., Miller, G., Panova, Tatiana, Russell, Jackie, Ray, S., Ray, Swagat, Volkov, Arsen, Zomerdijk, Joost C. B. M.   +22 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Differential Regulation of Growth-Promoting Signalling Pathways by E-Cadherin [PDF]

, 2010
Background: Despite the well-documented association between loss of E-cadherin and carcinogenesis, as well as the link between restoration of its expression and suppression of proliferation in carcinoma cells, the ability of E-cadherin to modulate growth-
Dawn C Walker, Kirkwood, L.A., Lisa A Kirkwood, Dawn C. Walker, Georgopoulos, N.T., Lisa A. Kirkwood, Kirkwood Lisa A., Jennifer Southgate, Georgopoulos, Nikolaos T., Walker, Dawn C., Walker, D.C., Georgopoulos Nikolaos T., Nikolaos T. Georgopoulos, Kirkwood, Lisa A., Southgate, Jennifer, Southgate, J., Southgate Jennifer, Nikolaos T Georgopoulos, Walker Dawn C.   +18 more
core   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Local ligand concentration gradients induced by the plasma membrane

iScience
Summary: The plasma membrane is a dynamic structure surrounded by the extracellular matrix. Although stimulation of transmembrane proteins by soluble ligands takes place in this environment, its influence on receptor activation is usually overlooked.
Ágnes Szabó, Gabriella Tóth, Tímea Szatmári, Gábor Mocsár, István Rebenku, János Szöllősi, Peter Nagy   +6 more
doaj   +1 more source