Results 111 to 120 of about 2,009,855 (385)

Evasion of anti-growth signaling: a key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds [PDF]

, 2015
The evasion of anti-growth signaling is an important characteristic of cancer cells. In order to continue to proliferate, cancer cells must somehow uncouple themselves from the many signals that exist to slow down cell growth.
A.R.M. Ruhul Amin, Abraham, Adorno, Ahmad, Akhurst, Alan Bilsland, Albertoni, Alexandros G. Georgakilas, Amedeo Amedei, Amin, Amin, Amin, Amr Amin, Apelqvist, Arbiser, Aronchik, Asfar S. Azmi, Aster, Athar, Baek, Baek, Baek, Baek, Bagli, Bahr, Balasubramanyam, Banerjee, Barry, Bateman, Bauskin, Bean, Beckerman, Belletti, Berletch, Bhattacharyya, Bian, Bill Helferich, Bock, Bolos, Bolos, Bootcov, Bracken, Bray, Bray, Breen, Brooks, Brown, Brown, Brown, Buck, Bunney, Cancer Genome Atlas Research, Cantero, Cekanova, Chandra S. Boosani, Charles, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Cheng, Chintharlapalli, Choi, Choudhuri, Christofori, Classon, Clem, Cordero-Espinoza, Cornen, Costa, Covey, Cui, Dai, Dai, Dallas, Damera, Dameron, Daniels, Dardousis, Debeb, Decristofaro, Dell’Eva, Deng, Denissova, Dennis, Dhar, Di, Dickinson, Dickson, Ding, Dipita Bhakta, Dominguez, Dong, Dong M. Shin, Dorota Halicka, Dotsch, Douc-Rasy, Du, Dudas, Durfort, D’Angelo, Ehebauer, Elena Niccolai, Enderle, Engelman, Evans, Fang, Fang, Farabegoli, Faridoni-Laurens, Fernandez, Firth, Fischbach, Fotsis, Fox, Freed-Pastor, Friday, Fuggetta, Gabellini, Gao, Garcia, Garofalo, Gazala N. Khan, Giovannini, Gloria S. Huang, Goldstein, Griner, Grogan, Gualberto, Guan, Guan, Gudkov, Guha, Gui, Gullett, Guo, Guo, Guo, Guo, Gupta, Haddad, Hahm, Hahm, Hahn, Hald, Hanahan, Hardcastle, Hardtner, Harper, Hartog, Harvey, Hastak, Hayes, Heallen, Hebert, Hendrickson, Hennessy, Herman-Antosiewicz, Heyninck, Heyninck, Hiromasa Fujii, Ho-Young Lee, Hoffmann, Hollander, Holy, Hossain, Huang, Huang, Huang, Hudson, Humbel, Husaini, Hussain, Hwa, Ichimiya, Indovina, Ishida, Jack Arbiser, Jacque, Jang, Jerome, Ji, Jia, Jiang, Jin-Tang Dong, Joerg Reichrath, Jogie-Brahim, Johnson, Jones, Joshi, Jung, Kahlert, Kan, Kang, Kanya Honoki, Karpowicz, Katagiri, Katia Aquilano, Kaushik, Kennedy, Khan, Khaw, Khaw, Kim, Kim, Kim, Kim, Kim, Kim, Kim, King, Knudsen, Knuutila, Koduru, Kohno, Kong, Konishi, Kooijman, Koopmann, Koopmann, Kopelovich, Kovalev, Kunnumakkara, Kurosu, Kwak, Lai, Lam, Lamar, Lambert, Lamonte, Lanzilli, Leao, Lee, Lee, Lee, LeRoith, Leupin, Levine, Li, Li, Li, Li, Li, Li, Liang, Lichner, Licitra, Lin, Lin, Lin, Lindmark, Liu, Liu, Liu, Liu-Chittenden, Loukopoulos, Lundberg, Luo, Luo, Ma, Maher, Maillard, Majumdar, Malaguarnera, Mamo, Mankame, Maor, Maria Rosa Ciriolo, Martinez, Martinez-Garcia, Massi, Maxwell, McClatchey, McGrath, Medema, Mendivil, Menendez, Miele, Mimeault, Min, Mitra, Miyake, Miyamoto, Mizuno, Mohan, Moll, Moon, Moore, Morgillo, Murga, Murillo, Murtaugh, Nagl, Nahta, Nair, Nakamura, Nallet-Staub, Nandakumar, Nandan, Nandan, Nandan, Nasiri, National Cancer Genome Atlas Research, Nefedova, Negi, Ng, Nian, Nihal, Ogawara, Oh, Oh, Okuyama, Omer Kucuk, Ono, Osada, Ouchi, Overholtzer, Pal, Pankov, Park, Park, Peacock, Phillip A. Karpowicz, Pinnix, Pollak, Pollak, Ponnurangam, Pons, Pratheeshkumar, Premkumar, Rao, Reed, Reedijk, Reedijk, Reidy, Reinmuth, Reisman, Ren, Riedemann, Rita Nahta, Rizzo, Rogler, Rosenfeldt, Roy, Rufini, Ryan, S. Salman Ashraf, Sadava, Samani, Santer, Santoro, Sarkar, Sasiela, Sausen, Schlegelmilch, Schmidt, Selander, Senapati, Serrano, Shamim, Shammas, Shangary, Shankar, Shankar, Sharif, Sharma, Shi, Shih Ie, Shijun Mi, Shim, Shim, Shimizu, Shin, Shindo, Shnaper, Shrimali, Siddiqui, Singh, Sinha, Sjolund, Somaira Nowsheen, Sophie Chen, Sotoca, Staal, Staff, Stockhausen, Stoeltzing, Stupack, Su, Subbaramaiah, Suh, Sulma I. Mohammed, Sun, Sunahara, Sur, Szarc vel Szic, Tan, Tan, Tannapfel, Tao, Thaiparambil, Thamilselvan, Thomas E. Carey, Tian, Ting, Trimboli, Tsui, Ulanet, Ulbricht, Valenti, van der Veeken, Vanhara, Varelas, Varelas, Villanueva, Volate, Vousden, W. Nicol Keith, Wallace, Wallin, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Weinberg, Welsh, Wen, Weng, Werner, Werner, Wesolowska, Wetterau, Whitson, Wiegand, Wiklund, William, Wilson, Wolf, Wong, Wu, Wu, Wu, Wynne, Xie, Xing, Xu, Xue, Xujuan Yang, Yamaguchi, Yamamoto, Yan, Yang, Yang, Yang, Yasaei, Yavari, Yee, Yin, Ying, Yokomizo, Yokomizo, Yonekura, Youns, Yu, Yu, Yu, Yu, Zaika, Zang, Zanotto-Filho, Zender, Zgheib, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zhao, Zhao, Zheng, Zheng, Zhong, Zhu, Zhuo G. Chen, Zilfou, Zlotogorski   +515 more
core   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Estimating the synaptic current in a multi-conductance AMPA receptor model [PDF]

, 2010
A pre-synaptic neuron releases diffusing neurotransmitters such as glutamate that activate post-synaptic receptors. The amplitude of the post-synaptic current, mostly mediated by glutamatergic (AMPARs) receptors, is a fundamental signal that may generate an action potential.
arxiv   +1 more source

Connective tissue growth factor is a new ligand of epidermal growth factor receptor [PDF]

, 2013
Chronic kidney disease is reaching epidemic proportions worldwide and there is no effective treatment. Connective tissue growth factor (CCN2) has been suggested as a risk biomarker and a potential therapeutic target for renal diseases, but its specific ...
Abreu, Adams, Allen, Ardura, Asakura, Bradshaw, Bronte, Cabodi, Chen, Chen, De Winter, Dreux, El Zein, Flamant, Fragiadaki, Gao, Gao, Guha, Hao, Hashimoto, Humphries, Inoki, Juliano, Kim, Lam, Lautrette, Leask, Liu, Liu, Markiewicz, Melenhorst, Miranti, Moro, Ohtsu, Okada, Perbal, Phanish, Plow, Pourazar, Rachfal, Riser, Rojas, Ruiz-Ortega, Rupérez, Schwartz, Segarini, Sibilia, Slagman, Sweeney, Sánchez-López, Tam, Terzi, Wahab, Wang, Wang, Wolf, Yokoi   +56 more
core   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Interactions between Type III receptor tyrosine phosphatases and growth factor receptor tyrosine kinases regulate tracheal tube formation in Drosophila [PDF]

, 2012
The respiratory (tracheal) system of the Drosophila melanogaster larva is an intricate branched network of air-filled tubes. Its developmental logic is similar in some ways to that of the vertebrate vascular system.
Jeon, Mili, Scott, Matthew P., Zinn, Kai
core   +3 more sources

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Stochastic models of the binding kinetics of VEGF-A to VEGFR1 and VEGFR2 in endothelial cells [PDF]

arXiv, 2016
Vascular endothelial growth factor receptors (VEGFRs) are receptor tyrosine kinases (RTKs) that regulate proliferation, migration, angiogenesis and vascular permeability of endothelial cells. VEGFR1 and VEGFR2 bind vascular endothelial growth factors (VEGFs), inducing receptor dimerisation and activation, characterised by phosphorylation of tyrosine ...
arxiv  

The basic biology of erbB-2 and its participation in colorectal cancers [PDF]

, 2005
ErbB-2 is one of Tour cell surface growth factor receptors involved in transmission of signals controlling normal cell growth and differentiation. A range of growth factors serve as ligands, but none is specific for the ErbB-2 receptor.
Bryś, Magdalena, Krajewska, Wanda M., Stawińska, Magdalena   +2 more
core  

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source