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Hematopoietic growth factor receptors
Cytotechnology, 1989The formation of the cellular constituents of the blood is regulated by a series of endogenous polypeptides with largely paracrine function. A number of these hematopoietic growth factors (HGF's), which include colony stimulating factors, interleukins, and erythropoietin, have been purified to homogeneity and cloned, which in turn has led to extensive ...
Malcolm A.S. Moore, Jae-Hung Shieh
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Growth Factors and Receptors of Lymphocytes
1987To understand molecular mechanisms of clonal expansion of lymphocytes we have isolated cDNA clones for two lymphokines, interleukins (IL) 4 and 5 that induce proliferation and maturation of B-lymphocytes. Structures of IL-4 and IL-5 revealed a remote homology with other lymphokines such as IL-3 and gamma-interferon.
Yuji Saito +13 more
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1988
Growth factors and growth factor receptors may be involved in the abnormal growth characteristic of cancer, and both entities are encoded by known proto-oncogenes. Growth factors may act as self-stimulants (autocrine control stimulants of nearby cells(paracrine control), or stimulants of distant tissue (hormonal control).
Edison T. Liu +2 more
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Growth factors and growth factor receptors may be involved in the abnormal growth characteristic of cancer, and both entities are encoded by known proto-oncogenes. Growth factors may act as self-stimulants (autocrine control stimulants of nearby cells(paracrine control), or stimulants of distant tissue (hormonal control).
Edison T. Liu +2 more
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Receptors for Nerve Growth Factor
1993Publisher Summary This chapter discusses the two receptors for nerve growth factor (NGF)—namely, (1) the low-affinity NGF receptor and (2) the product of the proto-oncogene trk . It also reviews the way they were originally identified and the structural and functional features of the two receptors.
David S. Battleman +2 more
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Growth Factors, Growth-Factor Receptors and Oncogenes
Bio/Technology, 1985In this review we summarize the current knowledge of polypeptide growth factors, their receptors and oncogenes. Recent studies indicate that oncogenes are linked to growth factors and to growth factor receptors, suggesting that these molecules participate in the proliferation of normal and neoplastic cells.
A. Avivi +3 more
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Growth factors, their receptors and development
American Journal of Medical Genetics, 1989AbstractThe hypothesis is put forward that the localized production of growth factors and the regulation both of their receptors and their receptor‐triggered transmembrane signaling reactions played an important role in organ development. The developing palate is used as an example to support this hypothesis.
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1991
Proliferation of normal cells is regulated through the complex interaction of each cell with neighboring homologous and heterologous cells and extracellular tissue components forming its microenvironment. In addition to the cell-cell and cell-extracellular matrix contact, the proliferation of cells is regulated by a variety of soluble growth factors ...
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Proliferation of normal cells is regulated through the complex interaction of each cell with neighboring homologous and heterologous cells and extracellular tissue components forming its microenvironment. In addition to the cell-cell and cell-extracellular matrix contact, the proliferation of cells is regulated by a variety of soluble growth factors ...
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International Journal of Neuroscience, 1985
Nerve growth factor is a polypeptide hormone that is required for the normal growth and development of the embryonic sensory and sympathetic nervous systems. On these cells, there are two different receptors for the nerve growth factor. Recently, these receptors have been isolated from three cell types and shown to have essentially the same binding ...
David J. Ennulat +3 more
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Nerve growth factor is a polypeptide hormone that is required for the normal growth and development of the embryonic sensory and sympathetic nervous systems. On these cells, there are two different receptors for the nerve growth factor. Recently, these receptors have been isolated from three cell types and shown to have essentially the same binding ...
David J. Ennulat +3 more
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The epidermal growth factor receptor family [PDF]
Endocrine-Related Cancer, 2005 The epidermal growth factor receptor family consists of four receptor genes and at least 11 ligands, several of which are produced in different protein forms. They create an interacting system that has the ability to receive and process information that results in multiple outputs.
L.A. Bazley, William J. Gullick
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Growth factor receptors and medulloblastoma
Journal of Neuro-Oncology, 1996Growth factors and their receptors play important roles in the regulation of cell division, development and differentiation. Neurotrophins are growth factors which have not been shown, until recently, to be associated with human neoplasia. Medulloblastoma is a central nervous system tumor which is thought to arise from the external granule cell layer ...
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