Results 11 to 20 of about 1,124,319 (216)

Revisiting the IGF-1R as a breast cancer target

npj Precision Oncology, 2017
The type I insulin-like growth factor-1 receptor is a well-described target in breast cancer and multiple clinical trials examining insulin-like growth factor-1 receptor have been completed.
Roudy Chiminch Ekyalongo, Douglas Yee
doaj   +1 more source

Activation of epidermal growth factor receptor/insulin-like growth factor 1 receptor-β-Catenin-CD44 pathway in periampullary cancer

Journal of Radiation and Cancer Research, 2020
Background: Periampullary cancer (PC) is a global medical burden. Less than 5% of patients experience an overall survival of 5 years or more. The study aims to analyze the importance of epidermal growth factor receptor (EGFR)/insulin-like growth factor 1
Biswabandhu Bankura, Suvendu Maji, Balarko Chakraborty, Neyaz Alam, Chinmay Kumar Panda   +4 more
doaj   +1 more source

The hepatocyte growth factor and its receptor [PDF]

STEM CELLS, 1996
Hepatocyte growth factor/scatter factor (HGF/SF) is secreted by cells of mesodermal origin and shows powerful mitogenic, motogenic and morphogenic activities on epithelial and endothelial cells. It is a heparin-binding polypeptide with an alpha/beta heterodimeric structure, showing structural homologies with enzymes of the blood clotting cascade.
GALIMI F., BRIZZI, Maria Felice, COMOGLIO, Paolo   +2 more
openaire   +5 more sources

Development of real-time reverse transcription polymerase chain reaction assays to quantify insulin-like growth factor receptor and insulin receptor expression in equine tissue

Onderstepoort Journal of Veterinary Research, 2013
The insulin-like growth factor system (insulin-like growth factor 1, insulin-like growth factor 2, insulin-like growth factor 1 receptor, insulin-like growth factor 2 receptor and six insulin-like growth factor-binding proteins) and insulin are essential
Stephen B. Hughes, Melvyn Quan, Alan Guthrie, Martin Schulman   +3 more
doaj   +1 more source

Endothelial platelet-derived growth factor-mediated activation of smooth muscle platelet-derived growth factor receptors in pulmonary arterial hypertension

Pulmonary Circulation, 2020
Platelet-derived growth factor is one of the major growth factors found in human and mammalian serum and tissues. Abnormal activation of platelet-derived growth factor signaling pathway through platelet-derived growth factor receptors may contribute to ...
Kang Wu, Haiyang Tang, Ruizhu Lin, Shane G. Carr, Ziyi Wang, Aleksandra Babicheva, Ramon J. Ayon, Pritesh P. Jain, Mingmei Xiong, Marisela Rodriguez, Shamin Rahimi, Francesca Balistrieri, Shayan Rahimi, Daniela Valdez-Jasso, Tatum S. Simonson, Ankit A. Desai, Joe G.N. Garcia, John Y.-J. Shyy, Patricia A. Thistlethwaite, Jian Wang, Ayako Makino, Jason X.-J. Yuan   +21 more
doaj   +1 more source

Epidermal growth factor receptor signaling [PDF]

Current Biology, 2001
Inhibitory signaling is an important way of fine tuning EGFR activity to enable a cell to discriminate between short and prolonged exposure to signaling molecules. Over the last few years a number of different mechanisms have been shown to abrogate receptor activity (Fig. 3Fig. 3). First, inhibitory signaling molecules are expressed in response to EGFR
Christian Klämbt, Sven Bogdan
openaire   +3 more sources

Essential growth factor receptors for fibroblast homeostasis and activation: Fibroblast Growth Factor Receptor (FGFR), Platelet Derived Growth Factor Receptor (PDGFR), and Transforming Growth Factor β Receptor (TGFβR) [version 2; peer review: 2 approved]

F1000Research
Fibroblasts are cells of mesenchymal origin that are found throughout the body. While these cells have several functions, their integral roles include maintaining tissue architecture through the production of key extracellular matrix components, and ...
Matthew B. Buechler, Maye F. Cheng, Faizah S. Abdullah   +2 more
doaj   +1 more source

Specific antibodies and sensitive immunoassays for the human epidermal growth factor receptors (HER2, HER3, and HER4)

Tumor Biology, 2017
The use of trastuzumab in patients with breast cancer that overexpresses human epidermal growth factor receptor 2 has significantly improved treatment outcomes.
Marianne Nordlund Broughton, Arne Westgaard, Elisabeth Paus, Miriam Øijordsbakken, Karoline J Henanger, Bjørn Naume, Trine Bjøro   +6 more
doaj   +1 more source

Fibroblast Growth Factor Receptor Functions in Glioblastoma

Cells, 2019
Glioblastoma is the most lethal brain cancer in adults, with no known cure. This cancer is characterized by a pronounced genetic heterogeneity, but aberrant activation of receptor tyrosine kinase signaling is among the most frequent molecular alterations
Ana Jimenez-Pascual, Florian A. Siebzehnrubl   +1 more
doaj   +1 more source

Rosetta Stone for Cancer Cure: Comparison of the Anticancer Capacity of Endogenous Estrogens, Synthetic Estrogens and Antiestrogens

Oncology Reviews, 2023
This work presents the history of the recognition of principal regulatory capacities of estrogen hormones having been mistakenly regarded as breast cancer promoting agents for more than 120 years.
Zsuzsanna Suba
doaj   +1 more source