Results 11 to 20 of about 2,000,472 (360)

Essential growth factor receptors for fibroblast homeostasis and activation: Fibroblast Growth Factor Receptor (FGFR), Platelet Derived Growth Factor Receptor (PDGFR), and Transforming Growth Factor β Receptor (TGFβR) [version 2; peer review: 2 approved]

F1000Research
Fibroblasts are cells of mesenchymal origin that are found throughout the body. While these cells have several functions, their integral roles include maintaining tissue architecture through the production of key extracellular matrix components, and ...
Matthew B. Buechler, Maye F. Cheng, Faizah S. Abdullah   +2 more
doaj   +3 more sources

Molecular Targeting of Epidermal Growth Factor Receptor (EGFR) and Vascular Endothelial Growth Factor Receptor (VEGFR)

Molecules, 2021
Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR) are two extensively studied membrane-bound receptor tyrosine kinase proteins that are frequently overexpressed in many cancers.
Nichole E. M. Kaufman, Simran Dhingra, Seetharama D. Jois, Maria da Graça H. Vicente   +3 more
doaj   +1 more source

Epidermal growth factor receptor (EGFR) gene alteration and protein overexpression in Malaysian triple-negative breast cancer (TNBC) cohort [PDF]

, 2019
Background: Epidermal growth factor receptor (EGFR) is a member of the ErbB family of tyrosine kinase receptor proteins that plays important roles in tumour cell survival and proliferation.
Abdul Raub, Sayyidi Hamzi, Azhari, Azlah Kamilah, Eswaran, Jeyanthy, Soundararajan, Meera, Syed Husain, Sharifah Noor Akmal, Wan Hasan, Wan Atiqah Najiah, Zakaria, Zubaidah, Zulkifle, Muhamad Farid   +7 more
core   +1 more source

Epidermal Growth Factor Receptor immunohistochemical expression in hepatocellular carcinoma without Epidermal Growth Factor Receptor exons 18–21 mutations

Romanian Journal of Internal Medicine, 2022
Introduction: EGFR targeted therapies, have been proved beneficial for patients with HCC, nevertheless additional research on EGFR immunoexpresion and EGFR mutations is still needed, especially in population in which it has not been done yet.
Nikolova Dafina, Trajkovska Meri, Trpcevska Emilija Nikolovska, Eftimov Aleksandar, Jovanovik Rubens, Janevska Vesna   +5 more
doaj   +1 more source

Metastatic Trends in Breast Cancer According to Molecular Subtypes, Estrogen Receptor, Progesterone Receptor and Human Epidermal Growth Factor Receptor 2neu Status

Journal of Medical Sciences and Health, 2022
Background : Breast cancer molecular subtypes have been established a close relationship with site specific metastasis, disease prognosis, selection of therapy and response to therapy.
Garima Uikey, Hemant Ahirwar, Rajesh Kori, Veenita YogI, Suresh Yadav, Om Prakash Singh, Rishika Saxena, Sachet Saxena   +7 more
doaj   +1 more source

Anti epidermal growth factor receptor therapy in small bowel adenocarcinoma [PDF]

, 2018
Rationale:Small bowel adenocarcinoma (SBA) is an uncommon gastrointestinal cancer, thus limited data about treatment for advanced disease are available.
Anselmi, Elisabetta, Falcone, Rosa, Filetti, Marco, Marchetti, Paolo, Roberto, Michela   +4 more
core   +1 more source

Intraocular Metastases Secondary to Breast Carcinoma Correlates With Upregulation of Estrogen and Progesterone Receptor Expression in the Primary Tumor [PDF]

, 2016
To compare estrogen (ER), progesterone (PR), and human epidermal growth factor-2 (HER2) receptor expression in the primary tumor of patients affected by choroidal metastases from breast carcinoma (BC) versus those with extraocular ...
Frizziero, Luisa, Midena, Edoardo, Miglionico, Giacomo, Parrozzani, Raffaele, Perrini, Pierdavide, Pilotto, Elisabetta, Pulze, Serena, Testi, Ilaria   +7 more
core   +1 more source

Rapamycin induces transactivation of the EGFR and increases cell survival. [PDF]

, 2009
The mammalian target of rapamycin (mTOR) signaling network regulates cell growth, proliferation and cell survival. Deregulated activation of this pathway is a common event in diverse human diseases such as cancers, cardiac hypertrophy, vascular ...
Chaturvedi, D, Cohen, MS, Gao, X, Patel, TB, Taunton, J   +4 more
core   +2 more sources

Inhibiting epidermal growth factor receptor at a distance. [PDF]

, 2014
The epidermal growth factor receptor (EGFR) tyrosine kinase is implicated in a large number of human cancers. Most EGFR inhibitors target the extracellular, growth factor-binding domain or the intracellular, ATP-binding domain. Here we describe molecules
Denton, Elizabeth, Schepartz, Alanna, Sinclair, Julie   +2 more
core   +2 more sources

Strategies for monitoring and combating resistance to combination kinase inhibitors for cancer therapy

Genome Medicine, 2017
Targeted therapies such as kinase inhibitors and monoclonal antibodies have dramatically altered cancer care in recent decades. Although these targeted therapies have improved patient outcomes in several cancer types, resistance ultimately develops to ...
Leanne G. Ahronian, Ryan B. Corcoran
doaj   +1 more source