Results 21 to 30 of about 2,009,855 (385)

A Systemic Receptor Network Triggered by Human cytomegalovirus Entry [PDF]

Advances in Virology Volume 2011 (2011), Article ID 262080, 11 pages, 2010
Virus entry is a multistep process that triggers a variety of cellular pathways interconnecting into a complex network, yet the molecular complexity of this network remains largely unsolved. Here, by employing systems biology approach, we reveal a systemic virus-entry network initiated by human cytomegalovirus (HCMV), a widespread opportunistic ...
arxiv   +1 more source

Antisense epidermal growth factor receptor RNA transfection in human glioblastoma cells down-regulates telomerase activity and telomere length [PDF]

, 2002
Epidermal growth factor receptor is overexpressed and/or amplified in up to 50% of glioblastomas, suggesting an important role of this gene in glial tumorigenesis and progression. In the present study we demonstrated that epidermal growth factor receptor
C Kunimura, CM Counter, EYY Chong, GA Ulaner, H Kameshima, H Kiaris, H Li, H-K Ng, HK Ng, J C-S Pang, J Chen, J Murakami, J Zheng, JP Morgenstern, K Dhaene, K Khazaie, K Liu, KJ Wu, M Yamada, P Pu, P Tang, S S T To, SS Kang, T Inui, WC Hahn, X-X Tian, XX Tian, XX Tian   +27 more
core   +2 more sources

Modulation of transforming growth factor beta signalling pathway genes by transforming growth factor beta in human osteoarthritic chondrocytes: involvement of Sp1 in both early and late response cells to transforming growth factor beta [PDF]

Arthritis Research \& Therapy, 2010, 13 (1), pp.R23. \. \<10.1038/sj.onc.1204808\>, 2015
Transforming growth factor beta (TGF$\beta$) plays a central role in morphogenesis, growth, and cell differentiation. This cytokine is particularly important in cartilage where it regulates cell proliferation and extracellular matrix synthesis. While the action of TGF$\beta$ on chondrocyte metabolism has been extensively catalogued, the modulation of ...
arxiv   +1 more source

Dynamic soluble changes in sVEGFR1, HGF, and VEGF promote chemotherapy and bevacizumab resistance: A prospective translational study in the BECOX (GEMCAD 09-01) trial [PDF]

, 2017
Despite initial responsiveness, acquired resistance to both bevacizumab and chemotherapy in metastatic colorectal cancer is universal. We have recently published that in vitro, chronically oxaliplatin resistance upregulates soluble vascular endothelial ...
Aparicico, J., Ayuso, J. R., Bohn, U., Bosch, C., Bouzas, R., Carmona, A., Casado, E., Escudero, P., Feliú, J., García-Albéniz, X., Gironella, M., Llorente, Beatriz, Maurel, J., Pineda, Estela, Pérez-Carrión, R., Ripollés, T., Safont, M. J., Salud, A., Vera, R., Vila-Navarro, E.   +19 more
core   +2 more sources

An EGFR T790M-mutated lung adenocarcinoma undergoing large-cell neuroendocrine carcinoma transformation after osimertinib therapy: a case report

Journal of Medical Case Reports, 2020
Background Osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor, is selective for both epidermal growth factor receptor tyrosine kinase inhibitor–sensitizing and T790M resistance mutations.
Shinichi Miyazaki, Yasumasa Kuno, Shunsaku Hayai, Ryo Teramachi, Ryo Yamashita, Yusuke Saito, Kosuke Higuchi, Yoshiharu Nara, Takuya Ikeda   +8 more
doaj   +1 more source

Functions of fibroblast growth factors and their receptors [PDF]

Current Biology, 1995
Fibroblast growth factors were first characterized twenty years ago as mitogens of cultured fibroblasts. Despite a wealth of data from experiments in vitro, insights have begun to emerge only recently on the normal function of these growth factors in mice and humans, as a result of studies of natural and experimental mutations in the factors and their ...
Wilkie, A, Morriss-Kay, G, Jones, E, Heath, J   +3 more
openaire   +3 more sources

Vascular endothelial growth factor receptor-1 mRNA overexpression in peripheral blood as a useful prognostic marker in breast cancer [PDF]

, 2012
INTRODUCTION: Identification of useful markers associated with poor prognosis in breast cancer patients is critically needed. We previously showed that expression of vascular endothelial growth factor receptor-1 mRNA in peripheral blood may be useful to ...
Akemi Kataoka, Hiroaki Ueo, Hiroshi Yamaguchi, Koshi Mimori, Masahiko Watanabe, Masaki Mori, Masaru Kuranami, Norihiko Sengoku, Sayuri Akiyoshi, Shinji Ohno, Yoshimasa Kosaka   +10 more
core   +2 more sources

Activation of epidermal growth factor receptor/insulin-like growth factor 1 receptor-β-Catenin-CD44 pathway in periampullary cancer

Journal of Radiation and Cancer Research, 2020
Background: Periampullary cancer (PC) is a global medical burden. Less than 5% of patients experience an overall survival of 5 years or more. The study aims to analyze the importance of epidermal growth factor receptor (EGFR)/insulin-like growth factor 1
Biswabandhu Bankura, Suvendu Maji, Balarko Chakraborty, Neyaz Alam, Chinmay Kumar Panda   +4 more
doaj   +1 more source

A novel inhibitor of p75-neurotrophin receptor improves functional outcomes in two models of traumatic brain injury. [PDF]

, 2016
The p75 neurotrophin receptor is important in multiple physiological actions including neuronal survival and neurite outgrowth during development, and after central nervous system injury.
Alam, Antoine, Arnone, Michele, Baroni, Marco, Beattie, Michael S, Bono, Françoise, Bresnahan, Jacqueline C, Canolle, Benoit, Castel, Marie-Noelle, Delbary-Gossart, Sandrine, Delesque-Touchard, Nathalie, Ferguson, Adam R, Ferzaz, Badia, Herbert, Jean-Marc, Laboudie, Patricia, Lamarche, Isabelle, Lee, Sangmi, Lin, Amity, Manley, Geoffrey T, Sacramento, Jeffrey, Salegio, Ernesto A, Savi, Pierre   +20 more
core   +1 more source

The hepatocyte growth factor and its receptor [PDF]

STEM CELLS, 1996
Hepatocyte growth factor/scatter factor (HGF/SF) is secreted by cells of mesodermal origin and shows powerful mitogenic, motogenic and morphogenic activities on epithelial and endothelial cells. It is a heparin-binding polypeptide with an alpha/beta heterodimeric structure, showing structural homologies with enzymes of the blood clotting cascade.
GALIMI F., BRIZZI, Maria Felice, COMOGLIO, Paolo   +2 more
openaire   +5 more sources