Results 311 to 320 of about 2,000,472 (360)
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Insulin‐Like Growth Factor Receptors
Acta Paediatrica, 1991AbstractCompetitive binding experiments from a number of laboratories showed that IGF receptors are distinct from insulin receptors, and that there are two types of IGF receptors based on their relative affinities for IGF-I and IGF-II and whether or not they bind insulin (reviewed in Rechler and Nissley, 1985).
E K, Neely +4 more
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British Medical Bulletin, 1989
The initial interaction of growth factors with their target cells is mediated by specific high affinity cell surface receptors. The structural and functional diversity found in growth factors is more limited at the receptor level where receptors for structurally and functionally distinct factors seem to share structural motifs and employ a restricted ...
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The initial interaction of growth factors with their target cells is mediated by specific high affinity cell surface receptors. The structural and functional diversity found in growth factors is more limited at the receptor level where receptors for structurally and functionally distinct factors seem to share structural motifs and employ a restricted ...
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Receptors for fibroblast growth factors
Immunology & Cell Biology, 1995SummaryThe recent discovery of the involvement of heparan sulfate proteoglycans (HSPG) in the activation of fibroblast growth factor receptors (FGFR) has led to an intensification of study of this field. It appears that the HSPG act as low affinity receptors to which the fibroblast growth factors (FGF) must bind in order to successfully activate the ...
J C, Coutts, J T, Gallagher
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Growth Factors and Their Receptors
Hematology/Oncology Clinics of North America, 1994Breast cancer represents a type of malignancy that is amenable to therapy targeting growth factors and receptors. There is considerable evidence that signaling mechanisms involving growth factors and their receptors are important in the normal development of breast epithelium.
D, Tripathy, C, Benz
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1991
Proliferation of normal cells is regulated through the complex interaction of each cell with neighboring homologous and heterologous cells and extracellular tissue components forming its microenvironment. In addition to the cell-cell and cell-extracellular matrix contact, the proliferation of cells is regulated by a variety of soluble growth factors ...
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Proliferation of normal cells is regulated through the complex interaction of each cell with neighboring homologous and heterologous cells and extracellular tissue components forming its microenvironment. In addition to the cell-cell and cell-extracellular matrix contact, the proliferation of cells is regulated by a variety of soluble growth factors ...
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Transforming growth factor-? receptors
Cytotechnology, 1989Transforming growth factor beta (TGF-β) binds specifically and with high affinity to several different cell surface proteins. Low M(r) proteins of 50,000 and 80,000 have been termed type I and type II receptors. Intermediate sized binding components of 115,000-140,000 M(r) and a high binding components of approximately 250,000 M(r) in subunit size have
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Endocytosis of growth factor receptors
BioEssays, 1993AbstractBinding of a growth factor (GF) to its specific receptor on the cell surface causes the initiation of a signal transduction cascade which eventually results in mitosis. GF:receptor complexes are removed from the cell surface via receptor‐mediated endocytosis, a process which involves clathrin‐coated pits.
A, Sorkin, C M, Waters
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Fibroblast Growth Factor Receptor Inhibitors
Current Pharmaceutical Design, 2012Fibroblast growth factor receptors (FGFRs) play an important role in embryonic development, angiogenesis, wound healing, cell proliferation and differentiation. The fibroblast growth factor receptor (FGFR) isoforms have been under intense scrutiny for effective anticancer drug candidates.
Suneel B V S, Kumar +4 more
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Insulin-like growth factor receptors
Journal of Cell Science, 1985ABSTRACT There are two types of insulin-like growth factor (IGF) receptors. The type I receptor generally binds IGF-I more tightly than IGF-II and also interacts weakly with insulin. The type II receptor prefers IGF-II over IGF-I and does not recognize insulin.
S P, Nissley +4 more
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Growth factors and growth factor receptors.
British journal of hospital medicine, 1993Peptide growth factors and their cell surface-associated receptors are important determinants of normal and pathological growth reactions. Through signal transduction pathways, receptor occupancy triggers the production of intracellular downstream effector molecules which ultimately cause cell proliferation.
M R, Alison, N A, Wright
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