Results 351 to 360 of about 2,009,855 (385)

Growth factors, their receptors and development

American Journal of Medical Genetics, 1989
AbstractThe hypothesis is put forward that the localized production of growth factors and the regulation both of their receptors and their receptor‐triggered transmembrane signaling reactions played an important role in organ development. The developing palate is used as an example to support this hypothesis.
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Growth factor receptors and medulloblastoma

Journal of Neuro-Oncology, 1996
Growth factors and their receptors play important roles in the regulation of cell division, development and differentiation. Neurotrophins are growth factors which have not been shown, until recently, to be associated with human neoplasia. Medulloblastoma is a central nervous system tumor which is thought to arise from the external granule cell layer ...
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Growth factors, receptors and cancer

BioEssays, 1986
AbstractIt now appears that the molecular events associated with the mitogenic action of growth factors are also the events perturbed in neoplastic lesions. This review outlines the relevance of our recent progress in the biochemistry of growth factors and their receptors to the induction and maintenance of the neoplastic state.
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Fibroblast Growth Factor Receptor Inhibitors

Current Pharmaceutical Design, 2012
Fibroblast growth factor receptors (FGFRs) play an important role in embryonic development, angiogenesis, wound healing, cell proliferation and differentiation. The fibroblast growth factor receptor (FGFR) isoforms have been under intense scrutiny for effective anticancer drug candidates.
Raveendra Dayam, Suneel Kumar B.V.S, Lakshmi Narasu, Rambabu Gundla, Sarma J.A.R.P   +4 more
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Growth factors and receptors in cancer

Current Opinion in Biotechnology, 1991
There have been a number of recent developments in mechanisms of action of growth factors and their receptors with particular relevance to cancer. The tyrosine kinase receptor family, in particular, has been shown to be important in tumour growth. These receptors are the products of oncogenes, or can interact with other oncogene pathways.
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Signal Transduction by Growth Factor Receptors [PDF]

, 1986
The proliferation of cells in vivo and in culture is tightly regulated by polypeptide growth factors. Like all polypeptide hormones, growth factors initiate their action by binding to specific, high affinity receptor molecules on the cell surface. Interest in growth factors and their receptors has been dramatically intensified by the discovery that at ...
W. H. Moolenaar, A. J. Bierman, L. H. K. Defize, B. C. Tilly, S. W. Laat   +4 more
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Regulation of Growth Factor Receptors by Gangliosides

Science Signaling, 2002
Since their discovery in the 1940s, gangliosides have been associated with a number of biological processes, such as growth, differentiation, and toxin uptake. Hypotheses about regulation of these processes by gangliosides are based on indirect observations and lack a clear definition of their mechanisms within the cell.
Eric G. Bremer, Eric G. Bremer, Erik A. Miljan, Erik A. Miljan   +3 more
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Activation of Epidermal Growth Factor Receptor by Epidermal Growth Factor

Biochemistry, 1996
The binding of epidermal growth factor (EGF) to epidermal growth factor receptor (EGF receptor) induces dimerization of the receptor and activation of its protein tyrosine kinase. Each of these three steps was followed as a function of the concentrations of EGF and of EGF receptor. Binding of EGF was followed by sedimentation of the complex between [3H]
Jennifer Miller Sherrill, Jack Kyte
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Transforming growth factor-? receptors

Cytotechnology, 1989
Transforming growth factor beta (TGF-β) binds specifically and with high affinity to several different cell surface proteins. Low M(r) proteins of 50,000 and 80,000 have been termed type I and type II receptors. Intermediate sized binding components of 115,000-140,000 M(r) and a high binding components of approximately 250,000 M(r) in subunit size have
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INSULIN-LIKE GROWTH FACTORS AND THEIR RECEPTORS IN GROWTH

Endocrinology and Metabolism Clinics of North America, 1996
The IGFs are essential stimulators of fetal and postnatal growth. Their signals are mediated predominantly by the type I IGF receptor, but another as yet unidentified receptor seems to mediate some actions, especially some of those for IGF-II. During organogenesis, the actions of IGF-I seem to be local (autocrine/paracrine), because it, as well as ...
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