Results 51 to 60 of about 2,009,855 (385)

Repurposed anti-cancer epidermal growth factor receptor inhibitors: mechanisms of neuroprotective effects in Alzheimer’s disease

Neural Regeneration Research, 2022
Numerous molecular mechanisms are being examined in an attempt to discover disease-modifying drugs to slow down the underlying neurodegeneration in Alzheimer’s disease.
Heba M Mansour, Hala M Fawzy, Aiman S El-Khatib, Mahmoud M Khattab   +3 more
doaj   +1 more source

Polar Chemoreceptor Clustering by Coupled Trimers of Dimers [PDF]

Biophys J 96(2): 453-463 (2009), 2009
Receptors of bacterial chemotaxis form clusters at the cell poles, where clusters act as "antennas" to amplify small changes in ligand concentration. Interestingly, chemoreceptors cluster at multiple length scales. At the smallest scale, receptors form dimers, which assemble into stable timers of dimers.
arxiv   +1 more source

Activation of tyrosine kinases by mutation of the gatekeeper threonine. [PDF]

, 2008
Protein kinases targeted by small-molecule inhibitors develop resistance through mutation of the gatekeeper threonine residue of the active site. Here we show that the gatekeeper mutation in the cellular forms of c-ABL, c-SRC, platelet-derived growth ...
Azam, Mohammad, Daley, George, Gray, Nathanael, KURIYAN, John, Seeliger, Markus   +4 more
core   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Specific antibodies and sensitive immunoassays for the human epidermal growth factor receptors (HER2, HER3, and HER4)

Tumor Biology, 2017
The use of trastuzumab in patients with breast cancer that overexpresses human epidermal growth factor receptor 2 has significantly improved treatment outcomes.
Marianne Nordlund Broughton, Arne Westgaard, Elisabeth Paus, Miriam Øijordsbakken, Karoline J Henanger, Bjørn Naume, Trine Bjøro   +6 more
doaj   +1 more source

Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer. [PDF]

, 2016
Expression of the oncogenic transcription factor MYC is disproportionately elevated in triple-negative breast cancer (TNBC), as compared to estrogen receptor-, progesterone receptor- or human epidermal growth factor 2 receptor-positive (RP) breast cancer.
Anderton, Brittany, Balakrishnan, Sanjeev, Camarda, Roman, Eyob, Henok, Goga, Andrei, Kajimura, Shingo, Kohnz, Rebecca A, Krings, Gregor, Mahieu, Celine, Nomura, Daniel K, Tward, Aaron, Zhou, Alicia Y   +11 more
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Inter-dependent Tissue Growth and Turing Patterning in a Model for Long Bone Development [PDF]

, 2013
The development of long bones requires a sophisticated spatial organization of cellular signaling, proliferation, and differentiation programs. How such spatial organization emerges on the growing long bone domain is still unresolved. Based on the reported biochemical interactions we developed a regulatory model for the core signaling factors IHH ...
arxiv   +1 more source

Sustained proliferation in cancer: mechanisms and novel therapeutic targets [PDF]

, 2015
Proliferation is an important part of cancer development and progression. This is manifest by altered expression and/or activity of cell cycle related proteins.
Abdelwahab, Abel, Acconcia, Acconcia, Acker, Adams, Adams, Agarwal, Agbarya, Aggarwal, Aggarwal, Aguirre-Ghiso, Ahn, Akiyama, Alan Bilsland, Alexandros G. Georgakilas, Ali, Alla Arzumanyan, Amedeo Amedei, Amin, Amr Amin, Aoki, Arbiser, Ascenzi, Asfar S. Azmi, Avila, Axanova, Bae, Bansal, Bao, Bao, Bao, Bar, Bar-Sela, Bardin, Barnes, Barone, Barrallo-Gimeno, Barretina, Basnet, Batlle, Bauer, Baumgarten, Baychelier, Beachy, Bell, Beltz, Bendinelli, Benitez, Bergers, Berman, Bermejo-Rodriguez, Berube, Bhatia, Bhattacharyya, Bhuiyan, Bilir, Bishayee, Bishayee, Bishayee, Bishayee, Bishayee, Blechschmidt, Blommaart, Boggess, Bolli, Bos, Bose, Brahimi-Horn, Brahimi-Horn, Brechbiel, Breen, Bross, Brouty-Boye, Brunt, Bryant, Buchdunger, Bulzomi, Bulzomi, Burgess, Butler, Buttari, Büchler, Caamaño, Cai, Cai, Cairns, Cao, Cardozo, Carew, Carew, Carmeliet, Cassinelli, Catalano, Cecchinato, Chai, Chandra S. Boosani, Chang, Chang, Charles, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Cheng, Cheng, Chiba, Chim, Choi, Choi, Choi, Choo, Choo, Clarke, Clement, Cloonan, Cobaleda, Crews, Criswell, Culig, Curran, Curtin, Dai, Danovi, De Wever, Degenhardt, Dejana, Delmas, DeNardo, Denissova, Deshpande, Dey, Diaz-Moralli, Dierks, Ding, Dipali Sharma, Dipita Bhakta, Dituri, Divya, Dorai, Dorota Halicka, Dotan, Dotan, Du, Duce, Durfort, Eder, Elamin, Elena Niccolai, Elstrom, Eramo, Escriva, Eskelinen, Falzacappa, Fan, Fan, Fan, Fan, Fan, Fang, Fang, Fang, Fang, Farahi, Farnie, Farrell, Feldmann, Feng, Fiorentini, Fodde, Fotsis, Fouad, Fox, Franci, Frasor, Fu, Fuggetta, Fukushima, Fulda, Fuster, Gabellini, Gaggioli, Galien, Gallahan, Galluzzo, Galluzzo, Galluzzo, Gao, Gao, Garnett, Garrido, Georgescu, Ghayad, Gillies, Giovannucci, Gomez, Gonzalez-Perez, Gort, Greenhough, Grimberg, Guertin, Gunjan Guha, Guo, Guo, Guo, Guo, Guo, Gupta, Guruvayoorappan, Hadad, Hall, Hamburger, Han, Han, Han, Hanahan, Harris, Hartman, Hasima, Hassan, Hayden, He, He, He, Heavey, Heber, Hede, Hedvat, Heeg, Henderson, Hendrayani, Hershko, Hirata, Hiromasa Fujii, Hirota, Holmes-McNary, Holy, Hope, Hsieh, Hu, Hu, Huang, Huber, Hung, Huynh, Iida, Ikegawa, Ilic, Imamov, Imaoka, Imbert, Imtiyaz, International Human Genome Sequencing, Consortium, Ischenko, Isidro Sanchez-Garcia, Iwasaki, Izutani, Jacks, Jacques, Jagadeesh, Jagtap, Jaiswal, Jaitner, Jamal Mahajna, Janes, Jedinak, Jeng, Jhappan, Ji, Jin, Jin, Jobin, Johnson, Johnson, Jones, Juan, Kabil, Kaelin, Kaewpiboon, Kaikkonen, Kajita, Kakarala, Kanadzu, Kane, Kang, Kang, Kanya Honoki, Kapitsinou, Karin, Karin, Katia Aquilano, Kawaguchi, Kawamori, Keen, Keerthivasan, Kennedy, Khan, Khaw, Khuda-Bukhsh, Killian, Kim, Kim, Kim, Kim, Kim, Kimura, Kimura, Kinsell, Kinsell, Knopeke, Knutson, Koehl, Korkaya, Korkaya, Korkaya, Kozuki, Krishnan, Kroemer, Krop, Kucuk, Kuhad, Kuijjer, Kumar, Kumar, Kumar, Kundu, Kunnumakkara, Kwon, Kühl, LaBarge, Lacorazza, Lacorazza, Lagouge, Lander, Lanzilli, Lao, Larriba, Larsson, Lattrich, Lee, Lee, Lee-Chang, Leiser, Leitch, Lenz, Leone, Leong, Leontieva, Leow, Levine, Levy, Li, Li, Li, Li, Li, Li, Li, Li, Li, Li, Li, Li, Liao, Liao, Liao, Lin, Lin, Linsalata, Lissa, Listerman, Liu, Liu, Liu, Liu, Liu, Liu, Long, Lu, Luka, Luka, Luoto, Léotoing, Ma, Ma, Macheda, Maeyama, Mahajna, Mailander, Maiuri, Malanchi, Malhotra, Malumbres, Mani, Mani, Manna, Marconett, Marconett, Mardis, Maria L. Martinez-Chantar, Maria Marino, Maria Rosa Ciriolo, Marino, Marino, Mark A. Feitelson, Marra, Marsh Durban, Martelli, Martinez-Outschoorn, Martínez-Chantar, Martínez-Chantar, Martínez-Chantar, Mato, Mato, Mazzanti, McCubrey, McMahon, Melo, Memmott, Mendivil, Meng, Mills, Mimeault, Mimeault, Mineharu, Mintz, Mizushima, Mo, Monroe, Moore, Mosieniak, Mowla, Moyer, Mudd, Mueller, Murdoch, Musgrove, Myoung, Métivier, Nadal-Serrano, Nagahata, Nagy, Nair, Nakamura, Nakamura, Nakamura, Nakshatri, Narayanan, Narayanan, Neeraj K. Saxena, Neetu Singh, Negi, Nerurkar, Nguyen, Nieto, Nishi, Nishinakagawa, Niu, Nogueira, Noh, Nonn, Nwabo Kamdje, Nyquist, Ohtani, Oishi, Osakada, Osipo, Ostyn, Oswald, Oyama, O’Hare, Paggliaci, Pai, Palazon, Palmer, Palomero, Palozza, Pan, Panagiotis J. Vlachostergios, Panchal, Parekh, Park, Park, Park, Park, Parker, Patel, Pattingre, Pattingre, Peacock, Pece, Pece, Pedersen, Perdigoto, Peretz, Perez-Losada, Perez-Mancera, Perez-Mancera, Perkins, Perl, Pernicová, Platet, Polakis, Polyak, Pons, Prakobwong, Prasad, Prasad, Pratheeshkumar, Pratheeshkumar, Pratt, Péqueux, Qazi, Qi, Qian, Qiang, Qing, Quoc, Rajala, Randall F. Holcombe, Rangarajan, Rao, Rapisarda, Rasanen, Rausch, Reguart, Reinmuth, Ren, Ren, Rietjens, Rius, Rob J. Kulathinal, Rodova, Roman Nawroth, Ronchini, Roper, Rosenfeldt, Rosich, Rossi, Ruiz, Ruoslahti, Rusnak, Russo, S. Salman Ashraf, Sabbah, Sachdev, Saito, Salim, Salpeter, Sandhiya, Sansone, Sansone, Sarkar, Sartippour, Sasaki, Sasaki, Saud, Sayeed, Schiff, Schneider, Seccareccia, Sehrawat, Sen, Sethi, Sethi, Shacka, Shackleton, Shah, Shakibaei, Shamim, Shan, Shan, Shanchun Guo, Shao, Shay, Shehzad, Sheth, Shih, Shim, Shin, Shinojima, Shioiri, Shiota, Shostak, Shukla, Signorelli, Singh, Singh, Slusarz, Smith, Smith, Somaira Nowsheen, Song, Song, Sophie Chen, Sotoca, Spiotto, Squires, Srivastava, Stacy W. Blain, Steelman, Stratton, Su, Su, Subbaramaiah, Sulma I. Mohammed, Sun, Sun, Sánchez-García, Sánchez-García, Tabruyn, Takada, Takahashi, Takeuchi, Talero, Talks, Tamari, Tan, Tang, Tang, Tang, Tang, Temraz, Tetsu, Thakur, The ENCODE Project Consortium, Thomas, Tirkey, Tobin, Tomellini, Tortorella, Tran, Trosko, Trumpp, Tsang, Tseng, Tyagi, Uckun, Uckun, Ugolini, Vanamala, Vanamala, Vander Broek, Vander Heiden, Vega, Velasco-Velázquez, Venter, Vera-Badillo, Vergara, Vernon, Vicente-Duenas, Vicente-Dueñas, Virgili, Vleminck, W. Nicol Keith, Wander, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Warner, Waterston, Watkins, Weisberg, Weljie, Wen, Wen, Weng, Wertz, Wesolowska, Westphalen, Wetterau, White, Whitehead, Whitehead, Wicha, Wickenden, Wilken, Wilkinson, Wilson, Wolanin, Wolter, Wong, Wong, Wray, Wu, Xia, Xia, Xiao, Xie, Xu, Xu, Yaguchi, Yalcin, Yamaguchi, Yan, Yan, Yang, Yang, Yang, Yang, Yang, Ye, Yeh, Yeh, Yokoyama, Yoshida, Yu, Yuasa, Zaidman, Zaidman, Zeng, Zeuner, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zheng, Zhong, Zhou, Zhou, Zhu, Zhu, Zimmerman, Zou, Zumsteg   +744 more
core   +2 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source