Fibroblast Growth Factor Receptors (FGFRs) and Noncanonical Partners in Cancer Signaling [PDF]
Cells, 2021 Increasing evidence indicates that success of targeted therapies in the treatment of cancer is context-dependent and is influenced by a complex crosstalk between signaling pathways and between cell types in the tumor.
Harriet R. Ferguson +2 more
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Nanodelivery Systems Targeting Epidermal Growth Factor Receptors for Glioma Management [PDF]
Pharmaceutics, 2020 A paradigm shift in treating the most aggressive and malignant form of glioma is continuously evolving; however, these strategies do not provide a better life and survival index.
Sathishbabu Paranthaman +7 more
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The role of growth factor receptors in viral infections: An opportunity for drug repurposing against emerging viral diseases such as COVID‐19? [PDF]
FASEB BioAdvances, 2020 Growth factor receptors are known to be involved in the process of viral infection. Many viruses not only use growth factor receptors to physically attach to the cell surface and internalize, but also divert receptor tyrosine kinase signaling in order to
Hubert Hondermarck +2 more
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Fibroblast Growth Factor Receptors (FGFRs): Structures and Small Molecule Inhibitors [PDF]
Cells, 2019 Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases expressed on the cell membrane that play crucial roles in both developmental and adult cells.
Shuyan Dai +4 more
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Essential growth factor receptors for fibroblast homeostasis and activation: Fibroblast Growth Factor Receptor (FGFR), Platelet Derived Growth Factor Receptor (PDGFR), and Transforming Growth Factor β Receptor (TGFβR). [PDF]
F1000ResFibroblasts are cells of mesenchymal origin that are found throughout the body. While these cells have several functions, their integral roles include maintaining tissue architecture through the production of key extracellular matrix components, and participation in wound healing after injury.
Cheng MF, Abdullah FS, Buechler MB.
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Cells, 2023 Integrins were originally identified as receptors for extracellular matrix (ECM) and cell-surface molecules (e.g., VCAM-1 and ICAM-1). Later, we discovered that many soluble growth factors/cytokines bind to integrins and play a critical role in growth ...
Yoshikazu Takada +2 more
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Cadherins and catenins in cancer: connecting cancer pathways and tumor microenvironment
Frontiers in Cell and Developmental Biology, 2023 Cadherin-catenin complexes are integral components of the adherens junctions crucial for cell-cell adhesion and tissue homeostasis. Dysregulation of these complexes is linked to cancer development via alteration of cell-autonomous oncogenic signaling ...
Wan-Hsin Lin +2 more
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Recent developments in receptor tyrosine kinases targeted anticancer therapy [PDF]
Veterinary World, 2016 Novel concepts and understanding of receptors lead to discoveries and optimization of many small molecules and antibodies as anti-cancerous drugs. Receptor tyrosine kinases (RTKs) are such a promising class of receptors under the investigation in past ...
Samir H. Raval +4 more
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Patologìâ, 2014 Aim. In immunohistochemical research of biopsy and postoperative material of 120 patients with the pancreatic ductal adenocarcinoma the levels of growth receptors of ErbB family and cancer prognostic markers expression were determined.
V. A. Tumanskiy , A. V. Evseyev
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Di-san junyi daxue xuebao, 2019 Objective To investigate the changes in the expression of fibroblast growth factor receptors 1-3 (FGFR1-3) at different stages of osteogenic differentiation and clarify the role of FGFR signaling in osteogenic differentiation.
MO Qifei, YANG Peng, SU Nan, CHEN Lin
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