Results 91 to 100 of about 1,257,265 (356)

Immunohistochemical evaluation of human epidermal growth factor receptor 2 and estrogen and progesterone receptors in breast carcinoma in Jordan [PDF]

, 2005
INTRODUCTION: Although breast carcinoma (BC) is the most common malignancy affecting Jordanian females and the affected population in Jordan is younger than that in the West, no information is available on its biological characteristics. Our aims in this
AA Abalkhail, AM Ruder, B Zafrani, CR De Potter, CW Elston, D Varshney, DC Allred, DH Choi, DJ Slamon, DJ Slamon, DJ Slamon, E May, Early Breast Cancer Trialists' Collaborative Group, ER Hoff, F Revillion, G Abadjian, G Arpino, G Pauletti, G Pauletti, GN Hortobagyi, HB Muss, J Ashba, J Yang, JA Ligibel, JM Esteban, Jordan Cancer Registry, Ministry of Health, JS Huston, JS Ross, K McKeage, LC Hartmann, LJ Layfield, LK Shawver, M Ferno, M Stierer, MF Kamal, Mohammad Al Hamad, Nidal M Almasri, O Stal, PL Porter, RH Mohammed, S Chariyalertsak, S Eppenberger-Castori, S Paik, S Taucher, SI Rosenthal, SS Amr, T el-A Helal, T Rajkumar, U Berger, W Hanna, WF Anderson, YF Dajani   +51 more
core   +2 more sources

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension. [PDF]

, 2018
Concentric lung vascular wall thickening due to enhanced proliferation of pulmonary arterial smooth muscle cells is an important pathological cause for the elevated pulmonary vascular resistance reported in patients with pulmonary arterial hypertension ...
Ayon, Ramon J, Balistrieri, Angela, Black, Stephen M, Chen, Jiwang, Desai, Ankit A, Garcia, Joe GN, Gu, Yali, Makino, Ayako, Rischard, Franz, Song, Shanshan, Tang, Haiyang, Vanderpool, Rebecca, Vinjamuri, Sujana, Wang, Jian, Wang, Ziyi, Wu, Kang, Yuan, Jason X-J, Zhang, Qian, Zhou, Guofei   +18 more
core   +1 more source

Vascular endothelial growth factor directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival [PDF]

, 2006
There are two types of neural stem cells (NSCs). Primitive NSCs [leukemia inhibitory factor (LIF) dependent but exogenous fibroblast growth factor (FGF) 2 independent] can be derived from mouse embryonic stem (ES) cells in vitro and from embryonic day 5 ...
Chaddah, R, Ema, M, Haigh, Jody, Hitoshi, S, Nagy, A, Rossant, J, van der Kooy, D, Wada, T   +7 more
core   +3 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The basic biology of erbB-2 and its participation in colorectal cancers [PDF]

, 2005
ErbB-2 is one of Tour cell surface growth factor receptors involved in transmission of signals controlling normal cell growth and differentiation. A range of growth factors serve as ligands, but none is specific for the ErbB-2 receptor.
Bryś, Magdalena, Krajewska, Wanda M., Stawińska, Magdalena   +2 more
core  

NGF-response of EGF-dependent progenitor cells obtained from human sympathetic ganglia [PDF]

, 1994
SIGNALLING molecules are thought to play a significant role in determining the fate of neural crest progenitor cells. The human sympathetic chain was identified at 6.5, 7.5, 8.2, 10.2 and 11.4 postconception (PC) weeks demonstrating low affinity nerve ...
Ampietro, A., Bernasconi, S., Borasio, Gian Domenico, Pizzuti, A., Scarlato, G., Silani, V., Zhou, F. C.   +6 more
core   +1 more source

Supplementary Fig. S2 from Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake [PDF]

, 2023
Yonglei Shang, Yifan Mao, Jennifer Batson, Suzie J. Scales, Gail D. Lewis Phillips, Mark R. Lackner, Klára Tótpál, Simon Williams, Jihong Yang, Zhijun Tang, Zora Modrušan, Christine Tan, Wei‐Ching Liang, Siao Ping Tsai, Alexander Vanderbilt, Kenji Kozuka, Klaus P. Hoeflich, Janet Tien, Sarajane Ross, Congfen Li, Sang Hoon Lee, An Song, Yan Wu, Jean-Philippe Stéphan, Avi Ashkenazi, Jiping Zha   +25 more
openalex   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Effects of EGFR Expression on Anti-tumor Efficacy of Vandetanib or Cediranib Combined with Radiotherapy (RT) in U87 Human Glioblastoma (GBM) Xenografts [PDF]

, 2010
Introduction: Vandetanib is a receptor tyrosine kinase inhibitor (RTKI) with activity against vascular endothelial growth factor receptor-2 (VEGFR-2) and epidermal growth factor receptor (EGFR).
Dicker, A. P., Lawrence, Y. R., Liu, Y., Wachsberger, P.   +3 more
core   +2 more sources