Results 211 to 220 of about 1,257,265 (356)

Changes in fibroblast growth factor receptors-1c, -2c, -3c, and -4 mRNA in granulosa and theca cells during ovarian follicular growth in dairy cattle. [PDF]

Domest Anim Endocrinol, 2022
Schütz LF, Hemple AM, Morrell BC, Schreiber NB, Gilliam JN, Cortinovis C, Totty ML, Caloni F, Aad PY, Spicer LJ.   +9 more
europepmc   +1 more source

Type 1 Insulin-like Growth Factor Receptor (IGF-IR) Signaling Inhibits Apoptosis Signal-regulating Kinase 1 (ASK1)

, 2003
Verónica Galván, Anna Logvinova, Sabina Sperandio, Hidenori Ichijo, Dale E. Bredesen   +4 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Functional Characterization of Variants of Unknown Significance of Fibroblast Growth Factor Receptors 1-4 and Comparison With AI Model-Based Prediction. [PDF]

JCO Precis Oncol
Ziegler M, Khoury N, Hommerich LM, Adler H, Loges S.   +4 more
europepmc   +1 more source

Fibroblast growth factor receptors in cancer: genetic alterations, diagnostics, therapeutic targets and mechanisms of resistance. [PDF]

Br J Cancer, 2021
Krook MA, Reeser JW, Ernst G, Barker H, Wilberding M, Li G, Chen HZ, Roychowdhury S.   +7 more
europepmc   +1 more source

A Novel Transforming Growth Factor-β Receptor-interacting Protein That Is Also a Light Chain of the Motor Protein Dynein

, 2002
Qian Tang, Cory M. Staub, Guofeng Gao, Qunyan Jin, Zhengke Wang, Wei Ding, Rosemarie Aurigemma, Kathleen M. Mulder   +7 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Remodeling the sarcoma microenvironment by simultaneous targeting of urokinase-type plasminogen activator receptors and epidermal growth factor receptors to promote antitumor activity. [PDF]

J Pharmacol Exp Ther
Schulte AJ, Lewellen M, Durose W, Nolan E, Taghizadeh L, Todhunter D, Bush C, Lang HP, Brown ME, DePauw TA, Makielski KM, Kim JH, Burt LE, Overn P, Forster CL, Seelig DM, O'Sullivan MG, Weigel BJ, Murugan P, Cutter GR, Lund TC, Vallera DA, Modiano JF.   +22 more
europepmc   +1 more source

Modular self-assembly system for development of oligomeric, highly internalizing and potent cytotoxic conjugates targeting fibroblast growth factor receptors. [PDF]

J Biomed Sci, 2021
Poźniak M, Porębska N, Jastrzębski K, Krzyścik MA, Kucińska M, Zarzycka W, Barbach A, Zakrzewska M, Otlewski J, Miączyńska M, Opaliński Ł.   +10 more
europepmc   +1 more source

Growth factor and receptor malfunctions associated with human genetic deafness

, 2019
Sadaf Naz, Thomas B. Friedman
openalex   +2 more sources