Results 311 to 320 of about 1,257,265 (356)

Fibroblast Growth Factor Receptor Inhibitors

Current Pharmaceutical Design, 2012
Fibroblast growth factor receptors (FGFRs) play an important role in embryonic development, angiogenesis, wound healing, cell proliferation and differentiation. The fibroblast growth factor receptor (FGFR) isoforms have been under intense scrutiny for effective anticancer drug candidates.
Suneel B V S, Kumar, Lakshmi, Narasu, Rambabu, Gundla, Raveendra, Dayam, Sarma, J A R P   +4 more
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Insulin-like growth factor receptors

Journal of Cell Science, 1985
ABSTRACT There are two types of insulin-like growth factor (IGF) receptors. The type I receptor generally binds IGF-I more tightly than IGF-II and also interacts weakly with insulin. The type II receptor prefers IGF-II over IGF-I and does not recognize insulin.
S P, Nissley, J F, Haskell, N, Sasaki, M A, De Vroede, M M, Rechler   +4 more
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Growth factors and growth factor receptors.

British journal of hospital medicine, 1993
Peptide growth factors and their cell surface-associated receptors are important determinants of normal and pathological growth reactions. Through signal transduction pathways, receptor occupancy triggers the production of intracellular downstream effector molecules which ultimately cause cell proliferation.
M R, Alison, N A, Wright
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Receptors for Nerve Growth Factor

1993
Publisher Summary This chapter discusses the two receptors for nerve growth factor (NGF)—namely, (1) the low-affinity NGF receptor and (2) the product of the proto-oncogene trk . It also reviews the way they were originally identified and the structural and functional features of the two receptors.
M V, Chao, D S, Battleman, M, Benedetti
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Growth Factors, Growth-Factor Receptors and Oncogenes

Bio/Technology, 1985
In this review we summarize the current knowledge of polypeptide growth factors, their receptors and oncogenes. Recent studies indicate that oncogenes are linked to growth factors and to growth factor receptors, suggesting that these molecules participate in the proliferation of normal and neoplastic cells.
R. M. Kris, T. A. Libermann, A. Avivi, J. Schlessinger   +3 more
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Epidermal Growth Factor, Epidermal Growth Factor Receptors, Intestinal Growth, and Adaptation

Journal of Parenteral and Enteral Nutrition, 1999
Epidermal growth factor (EGF) is an important constituent of several gastrointestinal secretions. Many studies in both animals and humans have shown EGF to have multiple effects upon gut epithelial cells. These include cytoprotection, stimulatory effects on cell proliferation and migration, induction of gene expression such as mucosal enzymes and ...
W M, Wong, N A, Wright
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Growth factor receptors and medulloblastoma

Journal of Neuro-Oncology, 1996
Growth factors and their receptors play important roles in the regulation of cell division, development and differentiation. Neurotrophins are growth factors which have not been shown, until recently, to be associated with human neoplasia. Medulloblastoma is a central nervous system tumor which is thought to arise from the external granule cell layer ...
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Growth factors, receptors and cancer

BioEssays, 1986
AbstractIt now appears that the molecular events associated with the mitogenic action of growth factors are also the events perturbed in neoplastic lesions. This review outlines the relevance of our recent progress in the biochemistry of growth factors and their receptors to the induction and maintenance of the neoplastic state.
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Epidermal growth factor receptor ≠ nerve growth factor

Neurobiology of Aging, 1989
I am perplexed by the authors' complete lack of definition of neurotrophic factors. The agents Butcher and Woolf want to blame are neurite promoting factors, not neurotrophic factors. Treatment of Alzheimer's disease with NGF antagonists might instead exacerbate the death of both basal forebrain neurons and their cortical target neurons, accelerating ...
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Growth factor and growth factor receptor in radiation carcinogenesis

Radiation and Environmental Biophysics, 1991
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