Results 31 to 40 of about 1,257,265 (356)

Triple negative breast cancer: new perspectives for targeted therapies [PDF]

, 2015
Breast cancer is a heterogeneous disease, encompassing a large number of entities showing different morphological features and having clinical behaviors.
Caruso, Davide, Frati, Luigi, Minozzi, Marina, Papa, Anselmo, Rossi, Luigi, Tomao, Federica, Tomao, Silverio, Vici, Patrizia, Zaccarelli, Eleonora   +8 more
core   +1 more source

Data‐driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states

Molecular Systems Biology, 2014
The extracellular signal‐regulated kinase (ERK) signaling pathway controls cell proliferation and differentiation in metazoans. Two hallmarks of its dynamics are adaptation of ERK phosphorylation, which has been linked to negative feedback, and ...
Shoeb Ahmed, Kyle G Grant, Laura E Edwards, Anisur Rahman, Murat Cirit, Michael B Goshe, Jason M Haugh   +6 more
doaj   +1 more source

Differential expression of growth factor receptors and membrane-bound tumor markers for imaging in male and female breast cancer. [PDF]

PLoS ONE, 2013
INTRODUCTION: Male breast cancer accounts for 0.5-1% of all breast cancers and is generally diagnosed at higher stage than female breast cancers and therefore might benefit from earlier detection and targeted therapy.
Jeroen F Vermeulen, Robert Kornegoor, Elsken van der Wall, Petra van der Groep, Paul J van Diest   +4 more
doaj   +1 more source

NRF2 regulates HER1 signaling pathway to modulate the sensitivity of ovarian cancer cells to lapatinib and erlotinib [PDF]

, 2017
NF-E2-related factor 2 (NRF2) regulates the transcription of a battery of metabolic and cytoprotective genes. NRF2 and epidermal growth factor receptors (EGFRs/HERs) are regulators of cellular proliferation and determinants of cancer initiation and ...
Bown, James L., Deeni, Yusuf Y., Hamza Kankia, Ibrahim, Khalil, Hilal S., Langdon, Simon P., Moult, Peter R.   +5 more
core   +12 more sources

VEGF-and EGF-mediated cooperation of eosinophilic granulocytes and tumor cells in gastric and colon cancer

Бюллетень сибирской медицины, 2019
Aim of the research – to analyze secretion of vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) by blood eosinophilic granulocytes in vitro, together with an expression of VEGFR and EGFR in tumor tissue in gastric and colon ...
Yu. V. Kolobovnikova, K. I. Yankovich, E. V. Romanova, A. I. Dmitrieva, O. I. Urazova, V. V. Novitskii, V. S. Poletika   +6 more
doaj   +1 more source

Modulation of Rab7a-mediated growth factor receptor trafficking inhibits islet beta cell apoptosis and autophagy under conditions of metabolic stress

Scientific Reports, 2020
Regenerative medicine approaches to enhancing beta cell growth and survival represent potential treatments for diabetes. It is known that growth factors such as insulin, IGF-1 and HGF support beta cell growth and survival, but in people with type 2 ...
Nirun V. Hewawasam, Fadel Lhaf, Henry A. Taylor, Katrina Viloria, Amazon Austin, Aileen King, Peter Jones, Lucy Jones, Mark D. Turner, Natasha J. Hill   +9 more
doaj   +1 more source

Epidermal growth factor receptor signaling [PDF]

Current Biology, 2001
Inhibitory signaling is an important way of fine tuning EGFR activity to enable a cell to discriminate between short and prolonged exposure to signaling molecules. Over the last few years a number of different mechanisms have been shown to abrogate receptor activity (Fig. 3Fig. 3). First, inhibitory signaling molecules are expressed in response to EGFR
Bogdan, Sven, Klämbt, Christian
openaire   +2 more sources

Activation of multiple growth factor signalling pathways is frequent in meningiomas [PDF]

, 2015
A minority of meningiomas are difficult to treat with surgery or radiotherapy, and chemotherapeutic alternatives are limited. This study aims to better understand pathways that are active in meningiomas, in order to direct future treatment strategies. We
Bassiri, K, Enki, DG, Hanemann, CO, Hilton, DA, Kirk, L, Shivane, A   +5 more
core   +2 more sources

Microvascularization and Expression of Fibroblast Growth Factor and Vascular Endothelial Growth Factor and Their Receptors in the Mare Oviduct

Animals, 2021
The oviduct presents the ideal conditions for fertilization and early embryonic development. In this study, (i) vascularization pattern; (ii) microvascular density; (iii) transcripts of angiogenic factors (FGF1, FGF2, VEGF) and their receptors—FGFR1 ...
Pedro Pinto-Bravo, Maria Rosa Rebordão, Ana Amaral, Carina Fernandes, António Galvão, Elisabete Silva, Pedro Pessa-Santos, Graça Alexandre-Pires, Rosário P. Roberto da Costa, Dariusz J. Skarzynski, Graça Ferreira-Dias   +10 more
doaj   +1 more source

Mouse genetics identifies unique and overlapping functions of fibroblast growth factor receptors in keratinocytes. [PDF]

J Cell Mol Med, 2020
Fibroblast growth factors (FGFs) are key regulators of tissue development, homeostasis and repair, and abnormal FGF signalling is associated with various human diseases.
Meyer M, Ben-Yehuda Greenwald M, Rauschendorfer T, Sänger C, Jukic M, Iizuka H, Kubo F, Chen L, Ornitz DM, Werner S.   +9 more
europepmc   +3 more sources