Results 221 to 230 of about 175,826 (264)

The Therapeutic Use of Growth-Hormone-Releasing Hormone

Journal of Pediatric Endocrinology and Metabolism, 1993
As a significant number of children with growth hormone deficiency have been shown to be able to respond to GHRH with a rise in serum growth hormone (GH) levels, GHRH has been used to treat such children with varying success. GHRH has been given subcutaneously (SC) in GH deficient children to improve growth in dose frequencies of daily, twice daily ...
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Growth Hormone-Releasing Hormone

Biology of the Neonate, 2009
Plasma growth hormone-releasing hormone (GHRH) was measured by radioimmunoassay in the cord blood from 32 healthy human newborns after 38–41 weeks of gestation. All were born by uncomplicated vaginal delivery. The GHRH levels in cord blood were 78.33 ± 8.35 pg/ml at 40 weeks of gestation, approximately threefold higher than the levels at 38 weeks of ...
Jesus Argente, Angelo Acquafredda, Luciano Cavallo, Marcel Donnadieu, Danièle Evain-Brion   +4 more
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Growth Hormone Releasing Hormone and Growth Hormone Releasing Hormone-Related Peptide in the Testis

1998
Growth hormone releasing hormone (GHRH) is a peptide synthesized in the cell bodies of neurosecretory neurons in the ventromedial and arcuate nuclei of the hypothalamus. When stimulated, GHRH travels down the axons of these neurons and is released into the hypophyseal portal circulation. GHRH binds to receptors on somatotrophs in the anterior pituitary,
K. K. Samaddar, T. M. Todoran, O. Hirsch Pescovitz   +2 more
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Role of growth hormone-releasing hormone on pentagastrin-induced growth hormone release in normal subjects

Journal of Endocrinological Investigation, 1991
In order to investigate the mechanisms by which gastrin cause GH release in humans we measured the GH response to pentagastrin alone (1.5 micrograms/kg/hour from 120 to 210 min) and following pretreatment with GHRH (GHRH 1-29,250 micrograms, iv at 0 min) in normal male subjects. Prior GHRH administration abolished the GH response to the second bolus of
J F, Garcia-Rojas, A, Mangas, A, Barba, J, Millan, C, Dieguez, E, Zamora   +5 more
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Growth Hormone Releasing Hormone

1999
Growth hormone (GH) synthesis and release is regulated by two hypothalamic peptides: somatostatin, which inhibits GH secretion, and growth hormone-releasing hormone (GHRH), which stimulates its release. Although somatostatin was the first to be identified in 1973 (1), the presence of a hypothalamic GH stimulating substance had been predicted in 1960 ...
Paul L. Hofman, O. H. Pescovitz
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Effect of Growth Hormone-Releasing Hormone and Clonidine on Growth Hormone Release in Type 1 Diabetic Patients

Hormone and Metabolic Research, 1987
We administered growth-hormone releasing hormone (GHRH), clonidine or thyrotropin-releasing hormone (TRH) as intravenous boli each in three different randomized mornings to nine well-controlled Type 1 diabetic men and to six age-matched healthy men who served as controls.
GIAMPIETRO, OTTAVIO, FERDEGHINI M, MICCOLI, ROBERTO, LOCATELLI V, CERRI M, YANAIHARA N, NAVALESI R, MULLER EE   +7 more
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Independent effects of growth hormone releasing factor on growth hormone release and gene transcription

Nature, 1985
The synthesis and secretion of growth hormone (GH) by the somatotropic cells of the anterior pituitary is under complex hormonal regulation. The hypothalamic peptides, growth hormone releasing factor (GHRF) and somatostatin, respectively stimulate and block GH release.
M, Barinaga, L M, Bilezikjian, W W, Vale, M G, Rosenfeld, R M, Evans   +4 more
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Somatostatin prevents the desensitizing action of growth hormone-releasing factor on growth hormone release

Peptides, 1987
We have investigated the effect of prior exposure to somatostatin (SRIF) alone or in combination with growth hormone-releasing factor (GRF) on the subsequent cyclic AMP and GH responses to GRF in rat anterior pituitary cells in primary culture. The maximal 4.5-fold stimulation of GH release induced by a 3-hr incubation with GRF is reduced by 60 ...
J, Simard, G, Lefèvre, F, Labrie
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Effects of Sex and Age on Pyridostigmine Potentiation of Growth Hormone-Releasing Hormone-Induced Growth Hormone Release

Neuroendocrinology, 2008
Previous studies have shown that pyridostigmine (PD) is capable of increasing the growth hormone (GH) response to GH-releasing hormone (GHRH) in young healthy subjects. In order to investigate the influence of age and sex on the PD potentiation of GHRH-induced GH release, we have studied the GH response to GHRH (50 µg i.v.) 1 h after oral ...
Corsello, Salvatore Maria, Tofani, A, Della Casa, Silvia, Rota, Carlo Antonio, Sciuto, R, Colasanti, Simonetta, Barini, Angelina, Barbarino, Antonino   +7 more
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Ghrelin and obestatin modulate growth hormone-releasing hormone release and synaptic inputs onto growth hormone-releasing hormone neurons.

The European journal of neuroscience, 2011
Ghrelin, a natural ligand of the growth hormone secretagogue receptor (GHS-R), is synthesized in the stomach but may also be expressed in lesser quantity in the hypothalamus where the GHS-R is located on growth hormone-releasing hormone (GHRH) neurons.
Feng, Dan D., Yang, Seung-Kwon, Loudes, Catherine, Simon, Axelle, Al-Sarraf, Tamara, Culler, Michael, Alvear-Perez, Rodrigo, Llorens-Cortes, Catherine, Chen, Chen, Epelbaum, Jacques, Gardette, Robert   +10 more
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