Results 301 to 310 of about 182,947 (342)

Growth Hormone Releasing Hormone

1999
Growth hormone (GH) synthesis and release is regulated by two hypothalamic peptides: somatostatin, which inhibits GH secretion, and growth hormone-releasing hormone (GHRH), which stimulates its release. Although somatostatin was the first to be identified in 1973 (1), the presence of a hypothalamic GH stimulating substance had been predicted in 1960 ...
Ora H. Pescovitz, Paul L. Hofman
openaire   +2 more sources

Somatostatin prevents the desensitizing action of growth hormone-releasing factor on growth hormone release

Peptides, 1987
We have investigated the effect of prior exposure to somatostatin (SRIF) alone or in combination with growth hormone-releasing factor (GRF) on the subsequent cyclic AMP and GH responses to GRF in rat anterior pituitary cells in primary culture. The maximal 4.5-fold stimulation of GH release induced by a 3-hr incubation with GRF is reduced by 60 ...
Gérard Lefèvre, Fernand Labrie, Jacques Simard   +2 more
openaire   +3 more sources

Growth Hormone-Releasing Peptides and Their Analogs

Frontiers in Neuroendocrinology, 1998
Growth hormone-releasing peptides (GHRPs) are a series of hepta (GHRP-1)- and hexapeptides (GHRP-2, GHRP-6, Hexarelin) that have been shown to be effective releasers of GH in animals and humans. More recently, a series of nonpeptidyl GH secretagogues (L-692,429, L-692,585, MK-0677) were discovered using GHRP-6 as a template.
CAMANNI, Franco, GHIGO, Ezio, ARVAT, Emanuela   +2 more
openaire   +4 more sources

Growth Hormone Releasing Hormone and Growth Hormone Releasing Hormone-Related Peptide in the Testis

1998
Growth hormone releasing hormone (GHRH) is a peptide synthesized in the cell bodies of neurosecretory neurons in the ventromedial and arcuate nuclei of the hypothalamus. When stimulated, GHRH travels down the axons of these neurons and is released into the hypophyseal portal circulation. GHRH binds to receptors on somatotrophs in the anterior pituitary,
O. Hirsch Pescovitz, K. K. Samaddar, T. M. Todoran   +2 more
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Effects of Sex and Age on Pyridostigmine Potentiation of Growth Hormone-Releasing Hormone-Induced Growth Hormone Release

Neuroendocrinology, 1992
Previous studies have shown that pyridostigmine (PD) is capable of increasing the growth hormone (GH) response to GH-releasing hormone (GHRH) in young healthy subjects. In order to investigate the influence of age and sex on the PD potentiation of GHRH-induced GH release, we have studied the GH response to GHRH (50 micrograms i.v.) 1 h after oral ...
Corsello, Salvatore Maria, Tofani, A, Della Casa, Silvia, Rota, Carlo Antonio, Sciuto, R, Colasanti, Simonetta, Barini, Angelina, Barbarino, Antonino   +7 more
openaire   +4 more sources

Growth hormone-releasing hormone and cancer

Reviews in Endocrine and Metabolic Disorders
The hypothalamic hormone growth hormone-releasing hormone (GHRH), in addition to promoting the synthesis and release of growth hormone (GH), stimulates the proliferation of human normal and malignant cells by binding to GHRH-receptor (GHRH-R) and its main splice variant, SV1. Both GHRH and GHRH-Rs are expressed in various cancers, forming a stimulatory
Gesmundo, Iacopo, Pedrolli, Francesca, Cai, Renzhi, Sha, Wei, Schally, Andrew V, Granata, Riccarda   +5 more
openaire   +3 more sources

Ghrelin and obestatin modulate growth hormone-releasing hormone release and synaptic inputs onto growth hormone-releasing hormone neurons

European Journal of Neuroscience, 2011
Ghrelin, a natural ligand of the growth hormone secretagogue receptor (GHS-R), is synthesized in the stomach but may also be expressed in lesser quantity in the hypothalamus where the GHS-R is located on growth hormone-releasing hormone (GHRH) neurons.
Catherine Loudes, Catherine Loudes, Robert Gardette, Robert Gardette, Rodrigo Alvear-Perez, Michael D. Culler, Chen Chen, Jacques Epelbaum, Jacques Epelbaum, Catherine Llorens-Cortes, Dan D. Feng, Tamara Al-Sarraf, Tamara Al-Sarraf, Axelle Simon, Axelle Simon, Seung-Kwon Yang, Seung-Kwon Yang   +16 more
openaire   +4 more sources

The Therapeutic Use of Growth-Hormone-Releasing Hormone

Journal of Pediatric Endocrinology and Metabolism, 1993
As a significant number of children with growth hormone deficiency have been shown to be able to respond to GHRH with a rise in serum growth hormone (GH) levels, GHRH has been used to treat such children with varying success. GHRH has been given subcutaneously (SC) in GH deficient children to improve growth in dose frequencies of daily, twice daily ...
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8 Growth hormone releasing hormone

Clinics in Endocrinology and Metabolism, 1986
Human growth hormone releasing hormone (GHRH) was originally extracted from two pancreatic tumours in patients with acromegaly, and is now known to consist of a 44 residue amidated peptide or its C-terminal-shortened derivatives. The sequence of rat GHRH has also been determined; this 43 residue peptide shows approximately 70% homology with human GHRH,
M.O. Ashley Grossman, Savage G.M. Besser
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Somatocrinin, the Growth Hormone Releasing Factor

1984
Publisher Summary This chapter discusses the isolation of tumor-derived and hypothalamic GRFs, structure-activity relationships of synthetic replicates of GRFs, in vitro studies on the mechanism of action of GRF, and antagonism between GRF and somatostatin.
Nicholas Ling, Peter Bohlen, Andrew Baird, Frederick Esch, Fusun N. Zeytin, William B. Wehrenberg, Roger Guillemin, Bertrand Bloch, Paul Brazeau, Christiane Mougin   +9 more
openaire   +3 more sources