Results 61 to 70 of about 513,294 (388)

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

FEBS Letters, EarlyView.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine, Matteo Mucci, Antonio Recchiuti, Domenico Mattoscio   +3 more
wiley   +1 more source

Involvement of GPR4 in increased growth hormone and prolactin expressions by extracellular acidification in MtT/S cells

The Journal of Reproduction and Development, 2020
Hormone-secreting pituitary adenomas show unregulated hormonal hypersecretion and cause hyperpituitarism. However, the mechanism of the unregulated hormone production and secretion has not yet been fully elucidated.
Shiori MUSHA, Saishu YOSHIDA, Syo MURAKAMI, Ryotaro KOJIMA, Masahito DEAI, Naoshi SASO, Chihiro MOGI, Koichi SATO, Fumikazu OKAJIMA, Hideaki TOMURA   +9 more
doaj   +1 more source

Glucagon stop-go kinetics supports a monomer-trimer fibrillation model [PDF]

Scientific Reports 5, (2015) 9005, 2014
We investigate in vitro fibrillation kinetics of the hormone peptide glucagon at various concentrations using confocal microscopy and determine the glucagon fibril persistence length $60 \mu\textrm{m}$. At all concentrations we observe that periods of individual fibril growth are interrupted by periods of stasis. The growth probability is large at high
arxiv   +1 more source

Molecular twist transition in chiral and racemic phospholipid monolayers detected by Maxwell-displacement-current measurements [PDF]

, 1999
The molecular basis for the little (lit) mouse phenotype, characterized by a hypoplastic anterior pituitary gland, is the mutation of a single nucleotide that alters Asp 60 to Gly in the growth hormone releasing factor receptor.
Iwamoto, M., Wu, C. X., Xu, X. B., Zhong-can, O. Y., 吴晨旭   +4 more
core   +1 more source

Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans.

Endocrinology, 2000
Ghrelin, a novel GH-releasing acylated peptide, was recently isolated from rat stomach. It stimulated the release of GH from the anterior pituitary through the GH secretagogue receptor (GHS-R).
Y. Date, M. Kojima, H. Hosoda, A. Sawaguchi, M. S. Mondal, T. Suganuma, S. Matsukura, K. Kangawa, M. Nakazato   +8 more
semanticscholar   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Mini-Review: Novel Therapeutic Strategies to Blunt Actions of Pneumolysin in the Lungs

Toxins, 2013
Severe pneumonia is the main single cause of death worldwide in children under five years of age. The main etiological agent of pneumonia is the G+ bacterium Streptococcus pneumoniae, which accounts for up to 45% of all cases.
Martin Leustik, Maritza Romero, Helena Pillich, Norman L. Block, Ferenc G. Rick, Jonathan Lawson, Alexander Verin, Aluya Oseghale, Umapathy Siddaramappa, Boris Gorshkov, Evgeny Zemskov, Supriya Sridhar, Istvan Czikora, Rudolf Lucas, Andrew V. Schally, Trinad Chakraborty   +15 more
doaj   +1 more source

A GHRHR founder mutation causes isolated growth hormone deficiency type IV in a consanguineous Pakistani family

Frontiers in Endocrinology, 2023
BackgroundIsolated growth hormone deficiency (IGHD) is caused by a severe shortage or absence of growth hormone (GH), which results in aberrant growth and development.
Safeer Ahmad, Muhammad Zeeshan Ali, Sumra Wajid Abbasi, Safdar Abbas, Iftikhar Ahmed, Shakil Abbas, Shoaib Nawaz, Mubarak Ziab, Ikhlak Ahmed, Khalid A. Fakhro, Khalid A. Fakhro, Khalid A. Fakhro, Muzammil Ahmad Khan, Ammira Al-Shabeeb Akil, Ammira Al-Shabeeb Akil   +14 more
doaj   +1 more source

Programmable models of growth and mutation of cancer-cell populations [PDF]

EPTCS 67, 2011, pp. 19-33, 2011
In this paper we propose a systematic approach to construct mathematical models describing populations of cancer-cells at different stages of disease development. The methodology we propose is based on stochastic Concurrent Constraint Programming, a flexible stochastic modelling language.
arxiv   +1 more source

Receptor oligomerization: from early evidence to current understanding in class B GPCRs [PDF]

, 2013
Dimerization or oligomerization of G protein-coupled receptors (GPCRs) are known to modulate receptor functions in terms of ontogeny, ligand-oriented regulation, pharmacological diversity, signal transduction, and internalization.
Chow, BKC, Lee, TO, Ng, SYL
core   +1 more source