Advanced Science, EarlyView.Icaritin demonstrates broad antitumor effects by inhibiting colorectal cancer (CRC) cell proliferation, migration, invasion, and causing cell cycle arrest. It induces apoptosis by repressing autophagic flux through disrupting HSP90‐TXNDC9 interactions.
Dan He +6 more
wiley +1 more source
Effect of growth hormone on ribonucleic acid metabolism. The template activity of the chromatin and molecular species of ribonucleic acid synthesized after treatment with the hormone [PDF]
, 1968 S. L. Gupta, G. P. Talwar
openalex +1 more source
Advanced Science, EarlyView.Testosterone enhances Aβ‐induced autophagy in microglia via the non‐genomic testosterone receptor GPRC6A, promoting Aβ clearance by suppressing ERK phosphorylation and inhibiting mTOR activation. In male 5xFAD mice, testicular removal reduces microglial autophagy and Aβ clearance, which is restored by testosterone.
Haiyan Du +8 more
wiley +1 more source
Radioimmunological behaviour of endogenous and exoqenous human growth hormone [PDF]
, 1974 Desalm, C. +4 more
core +1 more source
Effect of growth hormone on ribonucleic acid metabolism. 2. Effect of growth-hormone administration on the activities of 5′-nucleotidase, adenase, guanase and xanthine oxidase [PDF]
, 1962 NC Panda +3 more
openalex +1 more source
PPY‐Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer
Advanced Science, EarlyView.Pancreatic ductal adenocarcinoma features abundant stromal components that hinder therapy efficacy. Single‐cell RNA sequencing analysis combined with experiments identified PPY, a gastrointestinal hormone, as a novel inducer of immunosuppressive iCAFs. Mechanistic studies revealed that PPY activates the non‐canonical NF‐κB pathway via EGFR.
Mengdie Cao +14 more
wiley +1 more source
Advanced Science, EarlyView.Box C/D snoRNP complex regulates protein translation. This study identifies ZNHIT3 as a key component of the complex and ensures normal protein expression, including transcription factors orchestrating cell fate commitment, during early mouse embryogenesis.
Guanghui Yang, Qiliang Xin, Jurrien Dean
wiley +1 more source
EFFECTS OF HUMAN GROWTH HORMONE ON LEVELS OF BLOOD AND URINARY CARBOHYDRATE AND FAT METABOLITES IN MAN * [PDF]
, 1960 DOROTHY H. HENNEMAN, Philip H. Henneman
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A Model of Epigenetic Inheritance Accounts for Unexpected Adaptation to Unforeseen Challenges
Advanced Science, EarlyView.A general model of inheriting changes that are acquired during the lifetime of individuals demonstrates tremendous benefits to the population, including escape from extinction in changing environments. Contrasting the model with experimental data shows that inheritance of acquired changes enables rapid adaptation to unforeseen challenges, and accounts ...
Dino Osmanović +2 more
wiley +1 more source
Growth Hormone Secretion in the Unanesthetized Rhesus Monkey in Response to Noxious Stimuli1 [PDF]
, 1967 VIVECA MEYER, E. Knobil
openalex +1 more source