Results 211 to 220 of about 600,427 (260)
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2009
Human growth hormone (hGH) is a proteohormone secreted by the pituitary gland. It acts through binding to the hGH receptor, inducing either direct effects or initiating the production of insulin-like growth-factor I (IGF-I), the most important mediator of hGH effects.
Martin, Bidlingmaier +1 more
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Human growth hormone (hGH) is a proteohormone secreted by the pituitary gland. It acts through binding to the hGH receptor, inducing either direct effects or initiating the production of insulin-like growth-factor I (IGF-I), the most important mediator of hGH effects.
Martin, Bidlingmaier +1 more
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Dosing of Growth Hormone in Growth Hormone Deficiency
Hormone Research in Paediatrics, 1999Growth hormone (GH) treatment of GH-deficient (GHD) children is to a certain extent standardized worldwide. Recombinant 22 kDa GH is injected once daily by the subcutaneous route, mostly in the evening. The amount of GH injected (calculated per kg body weight or body surface area, expressed in terms of IU or mg) in prepubertal children mimics the known
M B, Ranke +3 more
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Mineral and Electrolyte Metabolism, 1994
Until a few years ago, growth hormone (GH) and insulin-like growth factor-1 (IGF-1) were considered essential only to the control of linear growth, glucose homeostasis, and for the maintenance of skeletal muscle mass. A large body of evidence recently coming from animal and human studies has unequivocally proven that the heart is a target organ for the
CITTADINI, ANTONIO +3 more
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Until a few years ago, growth hormone (GH) and insulin-like growth factor-1 (IGF-1) were considered essential only to the control of linear growth, glucose homeostasis, and for the maintenance of skeletal muscle mass. A large body of evidence recently coming from animal and human studies has unequivocally proven that the heart is a target organ for the
CITTADINI, ANTONIO +3 more
openaire +8 more sources
Pediatrics, 1966
THE RECENT cascade of knowledge of the chemistry and physiology of the protein and polypeptide hormones of the pituitary gland has been a consequence of steady progress over the past 20 years in methods of isolation, purification, and assay of these hormones.
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THE RECENT cascade of knowledge of the chemistry and physiology of the protein and polypeptide hormones of the pituitary gland has been a consequence of steady progress over the past 20 years in methods of isolation, purification, and assay of these hormones.
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European Journal of Pediatrics, 1989
Seven children with growth hormone deficiency of hypothalamic origin responded to an i.v. bolus of growth hormone releasing hormone (GHRH) (1-29)-NH2 with a mean serum increase of 10.7 ng/ml growth hormone (GH) (range 2.5-29.3 ng/ml). Continuous s.c.
O, Butenandt, B, Staudt
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Seven children with growth hormone deficiency of hypothalamic origin responded to an i.v. bolus of growth hormone releasing hormone (GHRH) (1-29)-NH2 with a mean serum increase of 10.7 ng/ml growth hormone (GH) (range 2.5-29.3 ng/ml). Continuous s.c.
O, Butenandt, B, Staudt
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Growth Hormone in Osteoporosis
Calcified Tissue Research, 1975In 1972, Harris et al. (1) reported a marked increase of cortical bone formation and calcium accretion in adult dogs treated with high doses of growth hormone. Since in osteoporosis, bone formation is insufficient to compensate for the bone loss, human growth hormone (HGH) appears to be a promising substance for the treatment of this bone condition ...
H G, Haas +7 more
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Growth Hormone and Cell Growth
2012Growth hormone (GH) promotes stem cell activation, cell proliferation, differentiation and survival, either directly or through the induction of IGF-1. GH acts via its cell membrane receptor to initiate a range of signalling pathways, with JAK2 kinase activation of STAT5 being the most important. The transcription factor STAT5 acts to induce expression
Waters, Michael J., Brooks, Andrew J.
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Clinical and Experimental Pharmacology and Physiology, 1999
SUMMARY1. The growth hormone (GH) receptor was the first of the class 1 cytokine receptors to be cloned. It shares a number of structural characteristics with other family members and common signalling mechanisms based on common usage of the Janus kinase 2 (JAK2).2.
Waters, M. J. +6 more
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SUMMARY1. The growth hormone (GH) receptor was the first of the class 1 cytokine receptors to be cloned. It shares a number of structural characteristics with other family members and common signalling mechanisms based on common usage of the Janus kinase 2 (JAK2).2.
Waters, M. J. +6 more
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Growth hormone- and growth-hormone-releasing hormone-producing tumors
1997Acromegaly, a clinical syndrome of disordered somatic growth and proportion, is usually caused by the unrestrained secretion of growth hormone (GH) by a pituitary adenoma and rarely may result from GH-releasing hormone (GHRH) secretion by an extrapituitary tumor.
I, Shimon, S, Melmed
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Growth and growth hormone secretion
Journal of Endocrinology, 1988Growth hormone pulse amplitude is intimately connected with growth in childhood. Its effects are most clear in middle childhood, although the influence of adrenal androgens is probably also important. In infancy, nutrition plays an important part and, in the adolescent growth spurt, the synergism with sex steroids is important. Detailed attention needs
C G, Brook, P C, Hindmarsh, R, Stanhope
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