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Growth and growth hormone: An overview
Growth Hormone & IGF Research, 2016Growth is a good indicator of a child's health. Growth disturbances, including short stature or growth failure, could be indications of illnesses such as chronic disease, nutritional deficits, celiac disease or hormonal abnormalities. Therefore, a careful assessment of the various requirements for normal growth needs to be done by history, physical ...
Enrique, Teran +2 more
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The Growth Hormone Receptor in Growth
Endocrinology and Metabolism Clinics of North America, 2007The growth hormone receptor (GHR) is a major effector of Human growth. Functional variants of the GHR include very rare loss-of-function mutations (pathology) and very common polymorphisms (physiology). Recent experimental data have clarified the mechanisms through which mutations of the GHR or Stat5 lead to growth hormone insensitivity and major ...
Pierre, Bougnères, Vincent, Goffin
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Growth hormone regulation of growth hormone-releasing hormone gene expression
Peptides, 1988Slot-blot hybridization technique was used to evaluate growth hormone-releasing hormone (GHRH) mRNA levels in the hypothalamus of long-term (14 days) hypophysectomized (HPX) rats treated or not with 125 micrograms hGH/rat, twice daily IP, since the first day postsurgery. In addition, mRNA levels were determined in the hypothalamus of short-term (4 days)
V. De GENNARO COLONNA +4 more
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Interactions of Growth Hormone Secretagogues and Growth Hormone-Releasing Hormone/Somatostatin
Endocrine, 2001The class of novel synthetic compounds termed growth hormone secretagogues (GHSs) act in the hypothalamus through, as yet, unknown pathways. We performed physiologic and histochemical studies to further understand how the GHS system interacts with the well-established somatostatin (SRIF)/growth hormone-releasing hormone (GHRH) neuroendocrine system for
G S, Tannenbaum, C Y, Bowers
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Sex differences in growth hormone response to growth hormone-releasing hormone
Journal of Endocrinological Investigation, 1991The aim of the present study was to ascertain whether sex differences exist in GH response to GHRH, and the influence that menstrual cycle have on this response. A GHRH test was performed on nine healthy men and ten women on days one and twelve of the menstrual cycle.
P, Benito +5 more
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Growth Hormone Responses to Continuous Infusions of Growth Hormone-Releasing Hormone*
The Journal of Clinical Endocrinology & Metabolism, 1985The pattern of GH secretion during a continuous 4-h iv infusion of 1 microgram/kg.h GH-releasing hormone (1-44)-NH2 (GHRH-44) or saline was examined in 15 adult men. There was prompt release of GH beginning within 20 min of starting the GHRH-44 infusions, reaching peak GH levels of 43 +/- 11 (+/- SE) ng/ml within 60-90 min.
M C, Gelato +7 more
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Growth hormone response to growth hormone-releasing hormone in schizophrenic patients
American Journal of Psychiatry, 1990Ten schizophrenic patients and five normal control subjects were challenged with growth hormone-releasing hormone in a pilot study investigating growth hormone secretion from the pituitary. The results suggest suprapituitary dysfunction in schizophrenia, but replication in a larger study is needed.
D I, Mayerhoff +4 more
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Reviews in Endocrine and Metabolic Disorders, 1998
Growth hormone (GH) actions impact growth, metabolism, and body composition and have been associated with aging and longevity. Lack of GH results in slower growth, delayed maturation, and reduced body size and can lead to delayed aging, increased healthspan, and a remarkable extension of longevity.
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Growth hormone (GH) actions impact growth, metabolism, and body composition and have been associated with aging and longevity. Lack of GH results in slower growth, delayed maturation, and reduced body size and can lead to delayed aging, increased healthspan, and a remarkable extension of longevity.
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Growth hormone response to growth hormone-releasing hormone and clonidine in depression
Biological Psychiatry, 1995Growth hormone (GH) responses to the alpha 2-adrenoceptor agonist clonidine and to GH-releasing hormone (GHRH) were measured in 12 patients fulfilling DSM-III-R criteria for major depressive disorder and in 12 age- and sex-matched controls. GH responses to clonidine correlated significantly with the GH responses to GHRH in the depressed patients as ...
Gann, Horst J. +4 more
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Growth Hormone-Releasing Hormone and Growth Hormone Secretagogues in Normal Aging
Endocrine, 2003Growth hormone (GH) secretion declines with aging, and parallels between normal aging and the signs and symptoms of adult GH deficiency have led to interest in the potential utility of replacing or stimulating GH to promote physical and psychological function and to prolong the capacity for independent living in older adults.
George R, Merriam +2 more
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