Results 231 to 240 of about 5,829,861 (298)

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Thyroid eye disease with teprotumumab-related hyperglycemia associated with increased growth hormone secretion. [PDF]

JCEM Case Rep
Sugawa K, Hataya Y, Murabe K, Fujimoto K, Iwakura T, Matsuoka N.   +5 more
europepmc   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Development and characterization of a long-acting allosteric growth hormone receptor antagonist for acromegaly.

Endocrinology
Kurylo K, Bouchard PR, Milton MN, Moesta PF, Dichtel LE, Gromada J, Ramanan V, Vincent T, Smith M, Chang CS, McGuire J, Shimkets R, Joing MP, Lehrer-Graiwer J, Cummings BB, Weiss EJ.   +15 more
europepmc   +1 more source

Impact of growth hormone treatment on childhood growth patterns in Kermanshah: A retrospective cohort study. [PDF]

J Educ Health Promot
Solouki L, Mahaki B, Zarei Bidsorkhy D, Jamal Jalal T, Mojabi HR, Tahvilian R.   +5 more
europepmc   +1 more source

Pituitary magnetic resonance imaging abnormalities and 1-year growth response in children with idiopathic growth hormone deficiency. [PDF]

Ann Pediatr Endocrinol Metab
Choe J, Lee J, Kim J.
europepmc   +1 more source

Weekly pegylated recombinant human growth hormone for prepubertal children with growth hormone deficiency: adherence advantage drives superior short-term efficacy over daily rhGH. [PDF]

Transl Pediatr
Guo H, Zhai Y, Yaheyajiang A, Mohemai Z, Liu L, Zheng L, Tuniyazi K.   +6 more
europepmc   +1 more source

Predictors of Response to Growth Hormone Treatment and Final Height in Medulloblastoma Survivors.

Horm Res Paediatr
Stern EZ, Ben-Ami M, Levy-Shraga Y, Toren A, Abebe-Campino G, Lurye M, Yalon M, Modan-Moses D.   +7 more
europepmc   +1 more source

[Growth hormone and fertility: molecular mechanisms and experience of adjuvant therapy in reproductology]. [PDF]

Probl Endokrinol (Mosk)
Volevodz NN, Vorontsova MV, Nevolnikov DY, Grigoryan OR, Vorotnikova SY, Mikheev RK.   +5 more
europepmc   +1 more source